Targeting Protein O-GlcNAcylation, a Link between Type 2 Diabetes Mellitus and Inflammatory Disease
Abstract
:1. Introduction
2. Hexosamine Biosynthetic Pathway (HBP) and O-GlcNAcylation
2.1. Hexosamine Biosynthetic Pathway (HBP)
2.2. Protein O-GlcNAcylation
3. Involvement of O-GlcNAcylation in Inflammation
3.1. Impact of O-GlcNAcylation on Inflammatory Signalling Pathways
3.1.1. Pro-Inflammatory Role of O-GlcNAcylation
3.1.2. Anti-Inflammatory Role of O-GlcNAcylation
3.2. Intrinsic Role of OGT and OGA in Inflammatory Pathways
4. Targeting O-GlcNAcylation in Inflammatory Derangements: Perspectives
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Bolanle, I.O.; Palmer, T.M. Targeting Protein O-GlcNAcylation, a Link between Type 2 Diabetes Mellitus and Inflammatory Disease. Cells 2022, 11, 705. https://doi.org/10.3390/cells11040705
Bolanle IO, Palmer TM. Targeting Protein O-GlcNAcylation, a Link between Type 2 Diabetes Mellitus and Inflammatory Disease. Cells. 2022; 11(4):705. https://doi.org/10.3390/cells11040705
Chicago/Turabian StyleBolanle, Israel Olapeju, and Timothy M. Palmer. 2022. "Targeting Protein O-GlcNAcylation, a Link between Type 2 Diabetes Mellitus and Inflammatory Disease" Cells 11, no. 4: 705. https://doi.org/10.3390/cells11040705
APA StyleBolanle, I. O., & Palmer, T. M. (2022). Targeting Protein O-GlcNAcylation, a Link between Type 2 Diabetes Mellitus and Inflammatory Disease. Cells, 11(4), 705. https://doi.org/10.3390/cells11040705