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COVID, Volume 4, Issue 9

September 2024 - 11 articles

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Cover Story: Human coronavirus 229E causes the rearrangement of host intracellular membranes to form replication organelles through hijacking members of the ESCRT pathway. We found that the ESCRT protein VPS4A was required for the formation of replication organelles and the localization of viral RNA to these structures. Mutation and inhibition of VPS4A significantly reduced virus replication and prevented the formation of replication organelles, exposing the viral RNA and triggering an inflammatory immune response. A similar phenomenon was observed for the OC43 coronavirus, indicating conservation across coronavirus genera. Furthermore, our data suggest that ESCRTs CHMP4B and VPS37A are required for virus replication and post-replication stages, respectively, highlighting the importance of ESCRTs in coronavirus replication. View this paper

Articles (11)

  • Article
  • Open Access
2 Citations
2,890 Views
28 Pages

Medical Student Voices on the Effect of the COVID-19 Pandemic and Motivation to Study: A Mixed-Method Qualitative Study

  • Thomas Mayers,
  • Yui Okamura,
  • Mai Kanaji,
  • Tomonari Shimoda,
  • Naoki Maki and
  • Tetsuhiro Maeno

23 September 2024

This study explores the impact of the COVID-19 pandemic on the motivation of medical students using a mixed-method, user-led approach with students as both participants and researchers. Data were collected in 2021 through essays describing students&r...

  • Article
  • Open Access
1,366 Views
9 Pages

The Role of COVID-19 Vaccination in Serological and Infectious Response in the Xokós Indigenous Community

  • Eloia Emanuelly Dias Silva,
  • Marina dos Santos Barreto,
  • Ronaldy Santana Santos,
  • Deise Maria Rego Rodrigues Silva,
  • Pedro Henrique Macedo Moura,
  • Pamela Chaves de Jesus,
  • Jessiane Bispo de Souza,
  • Adriana Gibara Guimarães,
  • Lucas Alves da Mota Santana and
  • Lysandro Pinto Borges

16 September 2024

Objectives: This study aims to examine the serological and infectious characteristics of the Xokós indigenous community in Brazil, both prior to and following COVID-19 immunization; Methods: Immunofluorescence assays were employed to identify...

  • Article
  • Open Access
1,620 Views
13 Pages

Geographical Mapping of COVID-19 Testing Rates in St. Louis: Influence of the Socioeconomic Index and Race on Testing in the Early Phase and Peak of the COVID-19 Pandemic

  • Samuel B. Governor,
  • William O. Effah,
  • Joshua Ntajal,
  • Cecilia Naa Ometse Nartey,
  • Viktoriya Voytovych,
  • Htu Sam,
  • Mark B. Ulanja,
  • Nhial T. Tutlam and
  • Prince Otchere

15 September 2024

Purpose: This study aimed to explore how race and the socioeconomic index (SES) of residential zip codes influenced COVID-19 testing rates in St. Louis during the early and peak phases of the pandemic. Method: An ecological study was conducted using...

  • Article
  • Open Access
2 Citations
2,457 Views
23 Pages

The Association between Self-Reported Long COVID Symptoms and COVID-19 Conspiracy Theories in Jordan and Kuwait

  • Malik Sallam,
  • Kholoud Al-Mahzoum,
  • Moudhi Ahmad Alenezi,
  • Maryam Alsaeed,
  • Fatmah Alsaeed,
  • Noor Albayati,
  • Sarah Alkhaldi,
  • Rawan J. Obeidat and
  • Muna Barakat

12 September 2024

Long COVID comprises persistent symptoms that extend beyond four weeks post-SARS-CoV-2 infection. The potential association between long COVID and the endorsement of COVID-19 conspiracy theories has not been explored, particularly in Arab countries,...

  • Review
  • Open Access
3 Citations
10,814 Views
27 Pages

10 September 2024

Since the WHO declared COVID-19 a pandemic, prominent social actors and institutions have warned about the threat of misinformation, calling for policy action to address it. However, neither the premises underlying expert claims nor the standards to...

  • Review
  • Open Access
1,735 Views
18 Pages

9 September 2024

The global pandemic sparked by the emergence of SARS-CoV-2 and its variants has imposed a substantial burden of morbidity and mortality. Central to the battle against these viral threats is the immune response, with a spotlight on the pivotal role pl...

  • Communication
  • Open Access
1,427 Views
9 Pages

The Subjective Well-Being of the Staff at a Teaching Dental Center in a COVID-19 Epidemiological Surveillance System between the Years 2020 and 2022

  • Fabiola Antonella Corituma-Basaldua,
  • Lucía Rafaela Negrón-Saldaña,
  • Carola Rojas-Susanibar,
  • Daniel Kevin Pérez-Alvarez,
  • María Claudia Garcés-Elías and
  • Roberto A. León-Manco

3 September 2024

Subjective well-being (SW) is understood as the personal judgment that an individual has about their value, perception, and level of satisfaction with respect to his or her life and existence. The present study had the purpose of understanding how pa...

  • Article
  • Open Access
1 Citations
4,341 Views
7 Pages

Enhanced External Counterpulsation Improves Dyspnea, Fatigue, and Functional Capacity in Patients with Long COVID

  • Jessie Fox,
  • Farhan Ali,
  • Marielisa Lopez,
  • Sachin A. Shah,
  • Christian W. Schmidt,
  • Odayme Quesada,
  • Timothy D. Henry and
  • Monica Verduzco-Gutierrez

2 September 2024

Approximately 31% of patients previously infected with SARS-CoV-2 are living with symptoms of long COVID in the United States. Long COVID significantly reduces quality of life and increases morbidity and disability; however, treatment options are lim...

  • Hypothesis
  • Open Access
25,120 Views
11 Pages

Could the Spike Protein Derived from mRNA Vaccines Negatively Impact Beneficial Bacteria in the Gut?

  • Alberto Rubio-Casillas,
  • Mark Fabrowski,
  • Carlo Brogna,
  • David Cowley,
  • Elrashdy M. Redwan and
  • Vladimir N. Uversky

25 August 2024

The emergence of mRNA vaccines for SARS-CoV-2 has opened a new page in vaccine development. Nevertheless, concerns of experts have been expressed about unintentional side effects on the gut microbiota (GM). Previous studies showed that this virus act...

  • Article
  • Open Access
1,659 Views
13 Pages

The Role of Intestinal Epithelial Permeability in Multisystem Inflammatory Syndrome in Children: A Case–Control Study

  • Cathal Roarty,
  • Clare Mills,
  • Claire Tonry,
  • Helen E. Groves,
  • Chris Watson and
  • Thomas Waterfield

24 August 2024

Background: Multisystem inflammatory syndrome in children (MIS-C) occurs after SARS-CoV-2 infection, with gastrointestinal symptoms a prominent feature. This syndrome has been proposed to be triggered by persistent SARS-CoV-2 antigenemia due to incre...

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