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BioMedInformatics, Volume 3, Issue 1

2023 March - 17 articles

Cover Story: In the construction of SARS-CoV-2 vaccines, abilities to attack the virus and elicit immunity are important factors. During vaccine production, finding proper structural features, especially 3D structures, is a critical step for appropriate biological responses. However, analyzing a huge number of structural features from experimental data is time consuming and costly. Therefore, new computational analysis, especially molecular structural analysis using deep learning, is attracting attention. Deep learning has the potential to solve problems in the vaccine manufacturing process owing to its high performance, automatic feature extraction, and high-speed big data processing, among others. View this paper
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Articles (17)

  • Opinion
  • Open Access
3 Citations
3,820 Views
7 Pages

Big Data in Chronic Kidney Disease: Evolution or Revolution?

  • Abbie Kitcher,
  • UZhe Ding,
  • Henry H. L. Wu and
  • Rajkumar Chinnadurai

Digital information storage capacity and biomedical technology advancements in recent decades have stimulated the maturity and popularization of “big data” in medicine. The value of utilizing big data as a diagnostic and prognostic tool h...

  • Study Protocol
  • Open Access
2 Citations
2,709 Views
8 Pages

Introduction: Digital health interventions are gradually being incorporated into the management of tuberculosis to ensure treatment adherence, but only a small number of trials focusing on latent tuberculosis infection (LTBI) care have tested and eva...

  • Article
  • Open Access
2 Citations
3,083 Views
32 Pages

Background: The Holter electrocardiogram (ECG) provides a long signal that represents the heart’s responses to both autonomic regulation and various phenomena, including heart tissue remodeling. Loss of information is a common result when using...

  • Systematic Review
  • Open Access
9 Citations
11,301 Views
27 Pages

With the increase in biosensors and data collection devices in the healthcare industry, artificial intelligence and machine learning have attracted much attention in recent years. In this study, we offered a comprehensive review of the current trends...

  • Article
  • Open Access
5 Citations
9,569 Views
16 Pages

An interesting issue observed in some drugs is the “double peak phenomenon” (DPP). In DPP, the concentration-time (C-t) profile does not follow the usual shape but climbs to a peak and then begins to degrade before rising again to a secon...

  • Article
  • Open Access
1 Citations
2,966 Views
13 Pages

Ablefit: Development of an Advanced System for Rehabilitation

  • Hugo Neves,
  • Arménio Cruz,
  • Rafael A. Bernardes,
  • Remy Cardoso,
  • Mónica Pimentel,
  • Filipa Margarida Duque,
  • Eliana Lopes,
  • Daniela Veiga,
  • Cândida Malça and
  • Vitor Parola
  • + 4 authors

Bedridden patients risk presenting several problems caused by prolonged immobility, leading to a long recovery process. There is thus a need to develop solutions that ensure the implementation of physical rehabilitation programs in a controlled and i...

  • Article
  • Open Access
4 Citations
2,548 Views
14 Pages

The radiation adaptive response effect is a biophysical phenomenon responsible for the enhancement of repair processes in irradiated cells. This can be observed in dedicated radiobiological experiments, e.g., where the small priming dose of ionising...

  • Article
  • Open Access
2 Citations
3,115 Views
9 Pages

Dementia is characterized as a decline in cognitive function, including memory, language and problem-solving abilities. In this paper, we conducted a Genome-Wide Association Study (GWAS) using data from the electronic Medical Records and Genomics (eM...

  • Review
  • Open Access
4 Citations
8,558 Views
26 Pages

Background: Nowadays, much research deals with the application of the automated meta-analysis of clinical trials through appropriate machine learning tools to extract the results that can then be applied in daily clinical practice. Methods: The autho...

  • Review
  • Open Access
8 Citations
6,219 Views
11 Pages

Artificial Intelligence in Bladder Cancer Diagnosis: Current Applications and Future Perspectives

  • Giulio Rossin,
  • Federico Zorzi,
  • Luca Ongaro,
  • Andrea Piasentin,
  • Francesca Vedovo,
  • Giovanni Liguori,
  • Alessandro Zucchi,
  • Alchiede Simonato,
  • Riccardo Bartoletti and
  • Francesco Claps
  • + 2 authors

Bladder cancer (BCa) is one of the most diagnosed urological malignancies. A timely and accurate diagnosis is crucial at the first assessment as well as at the follow up after curative treatments. Moreover, in the era of precision medicine, proper mo...

  • Article
  • Open Access
9 Citations
14,404 Views
20 Pages

Chest X-ray Abnormality Detection by Using Artificial Intelligence: A Single-Site Retrospective Study of Deep Learning Model Performance

  • Daniel Kvak,
  • Anna Chromcová,
  • Marek Biroš,
  • Robert Hrubý,
  • Karolína Kvaková,
  • Marija Pajdaković and
  • Petra Ovesná

Chest X-ray (CXR) is one of the most common radiological examinations for both nonemergent and emergent clinical indications, but human error or lack of prioritization of patients can hinder timely interpretation. Deep learning (DL) algorithms have p...

  • Article
  • Open Access
3 Citations
4,166 Views
9 Pages

Efficacy of the Use of Wii Games in the Physical and Functional Training of the Elderly: Protocol of a Systematic Review

  • Andreia Lima,
  • Maria Teresa Moreira,
  • Maria Salomé Ferreira,
  • Vítor Parola,
  • Dárcio Tadeu Mendes,
  • Maria do Perpétuo Nóbrega and
  • Carla Fernandes

Background: Scientific and technological development has constituted a reality in the lives of populations, making it unimaginable to live without specific incentives that development has allowed. That said, given the increase in the longevity of peo...

  • Review
  • Open Access
4 Citations
5,877 Views
19 Pages

Protein three-dimensional structural analysis using artificial intelligence is attracting attention in various fields, such as the estimation of vaccine structure and stability. In particular, when using the spike protein in vaccines, the major issue...

  • Article
  • Open Access
12 Citations
6,179 Views
10 Pages

Reliability of Artificial Intelligence-Assisted Cephalometric Analysis. A Pilot Study

  • Anna Alessandri-Bonetti,
  • Linda Sangalli,
  • Martina Salerno and
  • Patrizia Gallenzi

Recently, Artificial Intelligence (AI) has spread in orthodontics, in particular within cephalometric analysis, where computerized digital software is able to provide linear-angular measurements upon manual landmark identification. A step forward is...

  • Review
  • Open Access
30 Citations
18,200 Views
27 Pages

Ultrasound Elastography: Basic Principles and Examples of Clinical Applications with Artificial Intelligence—A Review

  • Maurizio Cè,
  • Natascha Claudia D'Amico,
  • Giulia Maria Danesini,
  • Chiara Foschini,
  • Giancarlo Oliva,
  • Carlo Martinenghi and
  • Michaela Cellina

Ultrasound elastography (USE) or elastosonography is an ultrasound-based, non-invasive imaging method for assessing tissue elasticity. The different types of elastosonography are distinguished according to the mechanisms used for estimating tissue el...

  • Article
  • Open Access
5 Citations
4,455 Views
16 Pages

Trecode: A FAIR Eco-System for the Analysis and Archiving of Omics Data in a Combined Diagnostic and Research Setting

  • Hindrik HD Kerstens,
  • Jayne Y Hehir-Kwa,
  • Ellen van de Geer,
  • Chris van Run,
  • Shashi Badloe,
  • Alex Janse,
  • John Baker-Hernandez,
  • Sam de Vos,
  • Douwe van der Leest and
  • Patrick Kemmeren
  • + 2 authors

The increase in speed, reliability, and cost-effectiveness of high-throughput sequencing has led to the widespread clinical application of genome (WGS), exome (WXS), and transcriptome analysis. WXS and RNA sequencing is now being implemented as the s...

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BioMedInformatics - ISSN 2673-7426