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BioChem, Volume 5, Issue 4

December 2025 - 12 articles

Cover Story: Skeletal muscle contraction shapes metabolic health and healthy ageing, not just movement. Higher strength is associated with lower cardiometabolic risk and mortality, and structured training produces measurable mitochondrial, vascular, and anti‑inflammatory adaptations in muscle. The article frames these changes as responses to specific mechanical “doses,” moving beyond generic exercise advice and positioning exercise science as a core treatment modality within integrative medicine. Skeletal muscle also acts as an endocrine organ: contraction‑evoked myokines can signal to adipose tissue, liver, vessels, and immune cells, supporting systemic benefits. Importantly, older muscle remains adaptable with appropriately prescribed resistance, aerobic, or combined functional training. This emerging field bridges performance science, exercise medicine, and rehabilitation in modern clinical care. View this paper
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Articles (12)

  • Article
  • Open Access
206 Views
15 Pages

Frequency of HLA-A, -B, -DRB1, and -DQB1 Alleles in Moroccan Adult Patients with Acute Myeloid Leukemia: A Case–Control Study

  • Khalid Laaziri,
  • Abdelmajid Zyad,
  • Fatima Ezzahra Lahlimi,
  • Ouadii Abakarim,
  • Illias Tazi,
  • Ikram Brahim,
  • Nadia Lakhouaja,
  • Raja Hazime,
  • El Mostafa Mtairag and
  • Brahim Admou

3 December 2025

Background/Objectives: Acute myeloid leukemia (AML) is the most common acute leukemia in adults, with over 50% of individuals succumbing to the disease annually. This study aimed to assess the correlation between human leukocyte antigen (HLA) genes a...

  • Systematic Review
  • Open Access
226 Views
15 Pages

1 December 2025

Background: Microglial cells are the resident immune cells in the central nervous system (CNS) and constitute the brain’s innate immune system. They are the smallest of the glial cells and are derived from phagocytic white blood cells, fetal mo...

  • Article
  • Open Access
271 Views
14 Pages

Drug Allergy in Hospitalized Patients: Three Years of Consultation Experience in a Tertiary Care Setting

  • Christian P. Ratti,
  • Alessandra Chiei Gallo,
  • Francesca Barei,
  • Alice Botta,
  • Matteo Cavara,
  • Eleonora Bono,
  • Lea Caron,
  • Valeria G. R. Ortolani and
  • Enrico Iemoli

1 December 2025

Background/Objectives: Drug hypersensitivity reactions (DHRs) are an important cause of morbidity in hospitalized patients, but their epidemiology and management in the inpatient setting are not well defined. Mislabeling of drug allergies may lead to...

  • Feature Paper
  • Review
  • Open Access
1 Citations
713 Views
23 Pages

Polyoxometalates’ Progress for the Treatment of Alzheimer’s Disease

  • Manuel Aureliano,
  • João Mateus and
  • David Manjua Rijo

20 November 2025

Alzheimer’s disease (AD) signifies a devastating impact on the quality of life of patients and their families. At a biomolecular level, AD is characterized by the deposition of extracellular plaques of β-amyloid (Aβ), affecting langua...

  • Review
  • Open Access
584 Views
33 Pages

18 November 2025

Alzheimer’s disease (AD), the leading cause of dementia, is defined by two pathological hallmarks, amyloid-β (Aβ) plaques and hyperphosphorylated tau tangles—both now structurally resolved at near-atomic precision thanks to cryo...

  • Article
  • Open Access
343 Views
21 Pages

Deamidation at N53 Causes SOD1 Structural Instability and Excess Zn Incorporation

  • Eric Zanderigo,
  • Phyllis Schram,
  • Owen Rogers,
  • Mikayla McLaughlin,
  • Colin A. Smith and
  • Alison L. O’Neil

13 November 2025

Background/Objectives: Approximately 20% of familial ALS (fALS) cases are linked to mutations in Cu/Zn superoxide dismutase (SOD1). Through a gain function, SOD1 misfolding exerts a toxic effect on motor neurons, leading to their degradation and ALS...

  • Review
  • Open Access
363 Views
16 Pages

7 November 2025

RASopathies are a heterogeneous group of genetic syndromes caused by germline mutations in genes encoding proteins of the RAS/MAPK pathway, which are essential in the regulation of cell proliferation, differentiation and survival. Although characteri...

  • Review
  • Open Access
1,503 Views
30 Pages

30 October 2025

Skeletal muscle is increasingly recognized as a dynamic endocrine organ whose secretome—particularly myokines—serves as a central hub for the coordination of systemic metabolic health, inflammation, and tissue adaptation. This review inte...

  • Article
  • Open Access
599 Views
11 Pages

14 October 2025

Background/Objectives: Ginsenosides, one of the most pharmaceutically valuable chemical compounds in Panax ginseng, are synthesized with several enzymes, including UGTs. UGTs determine absorbability and physiological function upon consumption. Thus,...

  • Review
  • Open Access
5,644 Views
49 Pages

Therapeutic Strategies Targeting Oxidative Stress and Inflammation: A Narrative Review

  • Charles F. Manful,
  • Eric Fordjour,
  • Emmanuel Ikumoinein,
  • Lord Abbey and
  • Raymond Thomas

6 October 2025

Oxidative stress and inflammation are deeply interconnected processes implicated in the onset and progression of numerous chronic diseases. Despite promising mechanistic insights, conventional antioxidant and anti-inflammatory therapies such as NSAID...

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BioChem - ISSN 2673-6411