Review Reports

Round 1

Reviewer 1 Report

Please read the attachment. Thank you.

Comments for author File: Comments.pdf

minor changes are needed.

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Reviewer 2 Report

The  present submission tried to explore the best possible combination that  can have a durable effect on diabetes management on a pathophysiologic perspective. The idea is interesting. However, a few concerns rising about the current version.  

1) what is the meaning of Trigs in the abstract?

2) In Figure 1, why the liver stay close to Pancreas? In other word, can liver develop a direct link with muscle or gut? Please explain the orders of tissue in the puzzle.

3) In Line 171, what is the meaning of 49 in 'UK Prospective Diabetes Study (UKPDS) 49'?

4) In Lines 348-351, the authors stated that ' the extra-glycemic benefits of each medication can work to cancel out the respective side effects of the other medication when used as a combination' Please discuss the theory. My feeling is that the possibility is very limited. 

Author Response

Please see the attachment.

Author Response File: Author Response.docx

Round 2

Reviewer 1 Report

Dear Editor and Authors:

Thank you for providing the point to point response.

The manuscript has been improved significantly. It is could be accepted for publication.

Please feel free to contact me if you have further requests or concerns.

Thank you for reading