Women, Volume 6, Issue 1 (March 2026) – 14 articles

This cross-sectional study aimed to assess the relationship between the level of physical activity and the severity of depressive symptoms in adult women, taking into account the mediating role of perceived stress and differences in this relationship across levels of depressive symptom severity. The study included 200 women aged 18–65 years. Physical activity was assessed using the International Physical Activity Questionnaire (IPAQ), depressive symptom severity was measured with the Beck Depression Inventory (BDI), and perceived stress was evaluated using a standardized stress scale. Descriptive statistics, non-parametric tests, hierarchical regression, mediation analysis with bootstrapping, and quantile regression (Q25, Q50, Q75) were applied, controlling for selected sociodemographic variables. The results showed that perceived stress was the strongest predictor of depressive symptom severity. Physical activity was not a significant independent predictor of depression after adjustment for stress; however, it demonstrated a significant indirect effect through stress reduction. Quantile regression analysis revealed that the protective effect of physical activity was more pronounced in the lower and middle quantiles of depressive symptom severity and attenuated at higher levels of severity. These findings indicate that the relationship between physical activity and depressive symptoms is predominantly indirect and conditional, supporting the integration of physical activity promotion with stress-reduction–focused interventions. Full article

This study aimed to assess maternal health profiles related to diet, pregnancy, and breastfeeding practices among 437 mothers with children under 24 months in a rural village in Madagascar, and to examine their association with maternal educational attainment using interviews and anthropometric data. Bivariate statistical analyses were performed to explore associations between maternal education level and all studied variables. Multivariate analyses were also conducted but did not yield reliable results and are therefore not presented. The findings showed that higher maternal education was strongly associated with better socioeconomic conditions; improved access to essential resources like food, clean water, and healthcare facilities; and greater dietary diversity. More educated women reported consuming a wider range of foods, reflecting better nutritional quality and potential benefits for maternal health. In contrast, education level did not significantly affect pregnancy-related care or breastfeeding practices as recommended by the WHO. This suggests that while education enhances women’s ability to access and choose nutritious diets, broader cultural or systemic factors may shape maternal care behaviors. Women with higher educational attainment had greater access to diverse and sufficient diets, which may contribute to improved maternal nutritional status. Sustainable interventions aimed at improving women’s education and nutritional literacy are needed to support informed dietary choices and improve maternal and child health outcomes. Full article

Endometriosis is a chronic inflammatory disorder affecting about 190 million women of reproductive age worldwide. It represents a major health challenge due to its broad impact on physical, reproductive, and psychological well-being and is clinically characterized by pelvic pain, menstrual irregularities, and infertility. This narrative review synthesized current evidence on the relationship between adiposity, metabolic and inflammatory markers, and endometriosis from a biopsychosocial and intersectional perspective. A comprehensive search was conducted in PubMed, Scopus, and Web of Science for peer-reviewed studies published in English over the past decade.: Results pointed out that endometriosis significantly affects inflammatory activity within adipose tissue, especially in visceral adipose tissue. Studies also reported reduced adipocyte size and altered adipose tissue function. The endometriosis cytokine profile exhibited a pattern of systemic and tissue-specific inflammatory activation (i.e., elevated levels of interleukin-6 and monocyte chemoattractant protein-1). Sociodemographic factors (i.e., age, race/ethnicity, socioeconomic status, and educational level) also play a significant role in differences in symptomatology, disease course, and healthcare access. To sum up, endometriosis need to be considered as a multisystem condition related to metabolic, inflammatory, and psychosocial factors. It is necessary to adopt a biopsychosocial and intersectional perspective to improve diagnosis and support more equitable and personalized therapeutic approaches. Full article

Aromatherapy, the therapeutic use of essential oils, is increasingly recognized as a complementary approach to women’s mental health, particularly during hormonally sensitive life stages such as menstruation, pregnancy, postpartum, and menopause. Concerns about the side effects of pharmacological treatments during these periods have driven interest in non-pharmacologic interventions. This narrative review synthesizes current clinical evidence on the efficacy of aromatherapy in alleviating psychological distress in women. A comprehensive literature review between 2000 and 2025 across PubMed, Scopus, and Web of Science databases identified 47 studies focusing on essential oils for anxiety, depression, or stress in female populations. The most substantial evidence supports the use of lavender, bergamot, rose, chamomile, clary sage, and ylang-ylang, with inhalation and massage as the most frequently studied delivery methods. Outcomes include reductions in cortisol, heart rate, and subjective stress, along with improvements in mood and emotional regulation. Aromatherapy demonstrates particular promise in postpartum and perimenopausal care. However, methodological heterogeneity and variability in oil composition limit generalizability. Despite these challenges, the evidence suggests that aromatherapy may serve as a safe, low-cost adjunct for managing mood disorders and stress in women, particularly when integrated into personalized, holistic care strategies. Full article

Genitourinary syndrome of menopause (GSM), which includes vulvovaginal atrophy (VVA) and other bothersome genitourinary symptoms, affects over half of postmenopausal women and has a considerable impact on quality of life. This study aimed to evaluate the efficacy and safety of an injectable combination of hyaluronic acid and amino acids for treating GSM-related symptoms. In this prospective, multicenter study, 84 women aged 46–60 with moderate to severe VVA confirmed by gynecological examination received three intradermal treatments at 21-day intervals, targeting the vestibule, introitus, lower vaginal wall, and labia majora. Symptom severity was assessed using a visual analog scale (VAS), while tolerability and satisfaction were evaluated via a five-point Likert scale. Quality of life was measured using the Satisfaction With Life Scale (SWLS). Assessments were conducted at baseline, after each injection, and at 3- and 6-month follow-up visits. After three months, significant improvements were noted in vaginal dryness, itching, burning, and dyspareunia (all p < 0.001). Patient satisfaction increased from 59.0% to 80.7%, and SWLS scores rose from 4.57 ± 1.76 to 6.53 ± 1.10, reflecting enhanced quality of life. The treatment was well tolerated and demonstrated a favorable safety profile. These findings suggest that this injectable formulation may represent an effective, non-hormonal option for women with VVA, particularly those who are not candidates for hormone therapy. Full article

Cervical cancer remains the main etiology of high morbidity and mortality among women in developing world despite the screening plans. In South Africa, screening policies are low. Attitude, knowledge, and practices (AKP) play a pivotal role in diagnosis, prevention and screening. The review explores AKP towards cervical cancer and screening including global and regional burden, and determinants of screening uptake. Previous empirical studies identifying factors influencing adherence to screening services were identified. Studies from 2020–2025 were searched using PubMed and Google databases. Identified terms and topics were combined using Boolean Operators and PRISMA guidelines. Keywords were “attitudes”, “knowledge”, “practice”, “current cervical cancer screening”, AND “South Africa”, “global”, “regional”, “burden”, “cervical cancer”, “screening uptake determinants ” and “cervical cancer screening”, “factors influencing adherence”, and “cervical cancer screening”, “practices and pap smear tests”, “strengths”, “limitations”, “future research”, AND (“cervical cancer screening”). Key findings: many women know cervical cancer or Pap smears but lack detailed knowledge about risk factors and screening protocols, actual Pap smear uptake is low. Fear of outcome of procedure, pain, or embarrassment are primary barriers, and lack of service access. A multidisciplinary approach involving healthcare providers, government and non-governmental organizations is crucial in addressing gaps in cervical cancer screening. Full article

African American (AA) women often experience earlier onset and more severe menopause symptoms, especially vasomotor symptoms (VMSs) like hot flashes, compared to other groups. However, limited research has examined the effectiveness and acceptability of menopause treatments in this population. This scoping review synthesized evidence on pharmacological (e.g., hormone replacement therapy [HRT], SSRIs, venlafaxine, nitroglycerin) and holistic (e.g., dietary changes, physical activity [PA], supplementation) approaches for managing menopause symptoms in AA women. Using Joanna Briggs Institute and PRISMA-ScR guidelines, a scoping review was conducted, guided by the PCC framework. Four databases (CINAHL, PsycInfo, PubMed, Scopus) were searched for English-language studies (2010–2025) involving AA women aged 40–65. Eligible studies included RCTs and observational designs with ≥10% AA participants. Data were charted and synthesized descriptively. Fourteen U.S.-based studies (11–53% AA representation) were included. Pharmacological treatments—especially HRT and SSRIs—were effective for VMSs and mood symptoms. Holistic approaches showed mixed outcomes; PA and magnesium offered modest benefit, while phytoestrogens sometimes worsened memory. Race-specific results were rarely reported. Effective pharmacological options exist, but evidence tailored to AA women is lacking. Future research must ensure greater AA representation and culturally responsive approaches to menopause care. Full article

This study discusses the challenges encountered in breast cancer screening coverage in Brazil. The aim was to verify mammography coverage in Brazil. A cross-sectional study was carried out using data provided by the Ministry of Health verifying the following information: method of detection, analysis of coverage, clinical and sociodemographic variables of breast cancer. We observed significant differences in the number of mammograms performed between Brazilian regions and between levels of education, which may be determining factors for adherence to the examination, as well as differences related to the collection period analyzed. Raising awareness among the population about the importance of mammography and training health professionals are fundamental to increasing coverage. It is necessary to invest in awareness-raising strategies and in a health care network prepared to welcome women with suspicious signs and symptoms, ensuring investigation and treatment. Full article

Despite the many benefits for both the mother and fetus of physical activity during pregnancy, only 12.7–37.8% of pregnant persons in the United States achieve the recommended 150 min of moderate-intensity physical activity per week. While many variables influence physical activity participation during pregnancy, social support has been associated with physical activity participation in various populations. Originally used in the study of criminology, the social support theory has been applied in recent evidence as a method of promoting physical activity and other healthy behaviors. Recent literature suggests that social support and co-participation are interpersonal facilitators of participation in physical activity. Therefore, we propose an integrated model through a combination of social support and co-participation in physical activity to increase physical activity during pregnancy: the SsCo-PAP Model. The practical advantage of this combination is that both social support and co-participation emphasize social connectedness to facilitate physical activity. We recommend that the model be utilized by clinicians to educate, encourage, and support their patients to be physically active during their pregnancy. Future research should analyze the feasibility and effectiveness of using the SsCo-PAP Model in clinical practice. Full article

Mastectomy, while a life-saving intervention for breast cancer, often leads to profound psychological and emotional challenges for affected women. Feelings of loss altered body image, and anxiety about recurrence can significantly impact mental well-being. This study aimed to explore and describe the experiences of women after mastectomy at Mankweng Tertiary Hospital in Limpopo Province, South Africa. In this study, a qualitative phenomenological design was used. Data were collected through semi-structured in-depth interviews with women who had undergone mastectomy. Fifteen participants were purposively sampled, and thematic analysis was used to identify key patterns and meanings in their narratives. The findings revealed that the participants initially described feelings of being ‘disabled’, incomplete, and anxious about cancer recurrence or their ability to perform maternal functions such as breastfeeding. However, over time, many developed resilience and acceptance, seeing surgery as a life-saving measure and an opportunity for renewal. The adjustment of women after mastectomy is a complicated emotional transition from crisis and loss to adjustment and empowerment. The results identify the need for holistic psychosocial support that combines counseling, peer networks, and education for their family members addressing their emotional healing, body image, and social reintegration. Full article

To improve shared decision-making about the potential risks and benefits of hormone therapy (HT), it is crucial to understand the joint effects of menopausal age and HT use on hypertension onset. This study examines the combined and individual effects of age at menopause and HT on hypertension onset in U.S. women based on their hysterectomy and oophorectomy history. This population-based, cross-sectional study included 4776 postmenopausal women with and without hysterectomy and oophorectomy history from the 2011–2020 National Health and Nutrition Examination Survey (NHANES). Age at hypertension onset was defined as the time scale at which a respondent was diagnosed with hypertension following the menopause onset. The weighted prevalence of hypertension was 40.0% (95% CI 38.2–41.8%) overall, highest in those who had an oophorectomy with or without hysterectomy (51.6%), followed by those with hysterectomy alone (45.3%), then in those with an intact uterus and ovaries (33.7%), p < 0.0001. Among women with an intact uterus and ovaries, those who experienced menopause before age 45 and used HT had a comparable risk of hypertension (aHR = 1.34, 95% CI: 0.81–2.22) to women who experienced menopause between ages 45 and 54 and did not use HT. Conversely, women who experienced menopause before age 45 and did not use HT showed a significantly increased risk of hypertension (aHR = 1.68, 95% CI: 1.27–2.22). The findings suggest that the absence of ovaries, with or without a uterus, HT use, and age at menopause are associated with the likelihood of hypertension development. This study highlights the need for personalized management and decision-making to reduce the risk of hypertension and cardiovascular disease in peri- and postmenopausal women. Full article

Poor satisfaction with one’s body is associated with obesity and emotional eating (EmE), especially in women. To improve behavioral obesity treatments, this study aimed to identify the effects of targeting the mediators of the body satisfaction–EmE relationship to improve weight-reduction outcomes. Women with Class II obesity (body mass index [BMI] of 35–39.9 kg/m²) were randomized into 6-month treatments targeting either increased physical activity and self-regulation (TARGETED group, n = 44) or standard weight management education (STANDARD group, n = 33). Improvements over 6 months in EmE, body satisfaction, mood, eating-related self-efficacy and self-regulation, and physical activity, and in weight over 6, 12, and 24 months, were significantly greater in the TARGETED group. Mood and eating-related self-efficacy mediated the body satisfaction–EmE relationship at baseline and the group–EmE change relationship. In the consideration of the treatment targets, increased physical activity predicted reduced EmE, mediated by mood change, and increased self-regulation predicted reduced EmE, mediated by self-efficacy change. Reduced EmE predicted weight losses. This research (a) identified psychological/behavioral mediators of the body satisfaction–EmE relationship; (b) ascertained methods associated with the improvement of those variables, their correlates, and interrelations; and (c) confirmed the viability of the indicated behavioral targets on EmE within a community-based obesity treatment. Given the identified associations with short- and longer-term weight losses, treatments were effectively informed. Full article

This study examined the consistency between clinical criteria, assigned priority level, and waiting time for elective hysterectomy, assessing whether higher priority translates into faster surgical access. We conducted a retrospective cohort study including 846 women who underwent the procedure between January 2018 and January 2024 at a public hospital in São Paulo, Brazil. The median waiting time was 6 months (IQR: 3–10), with wide variability ranging from 0.5 to 53 months. All components of the clinical score were associated with higher priority levels, demonstrating adequate discriminative ability to identify patients at greater clinical risk. However, assigned priority was not associated with shorter waiting times. Criteria reflecting greater clinical vulnerability, including duration of symptoms (β = +2.50 months), age (β = +1.00), and cardiovascular disease (β = +1.00), were paradoxically associated with longer waiting times, whereas anemia was the only factor associated with reduced waiting time (β = −1.00). These findings reveal a marked discrepancy between formal prioritization and actual surgical scheduling, underscoring the need for more objective and equity-oriented criteria in the management of surgical waiting lists. Full article

Adverse pregnancy outcomes (APOs) such as prematurity, low birth weight, stillbirth, and birth defects remain significant global health challenges. While many risk factors are known, APOs encompass a wide range of outcomes with diverse, sometimes poorly understood etiologies. Pregnancy-related acute kidney injury (PR-AKI) and liver injury are particularly associated with increased maternal and fetal mortality. This study investigated the association between hematological parameters, kidney and liver injury markers and adverse pregnancy outcomes. This cross-sectional study involved 714 pregnant women aged 18–40 years, conducted between August 2021 and August 2022. Maternal blood samples were collected before and after delivery to compare hematological parameters. Kidney and liver injury markers were measured using standard methods. The study analysed the association of these parameters with adverse pregnancy outcomes. The median age of participants was 24 years (Q1, Q3: 21, 26). Women with adverse pregnancy outcomes had statistically significant serum creatinine levels [0.52 mg/dL (0.45, 0.58)] compared to those without [0.50 mg/dL (0.44, 0.56)], although the difference was not clinically significant. Elevated Aspartate Transaminase (AST) levels (>90th percentile) were statistically associated with adverse pregnancy outcomes. Pairwise comparisons with Bonferroni corrections revealed significant differences in Hemoglobin (Hb), White Blood Cell (WBC), Red Blood Cell (RBC), platelet, and Packed Cell Volume (PCV) levels before and after delivery (p < 0.05) in both groups. Elevated AST levels, but not other hematological or biochemical parameters, were independently associated with adverse pregnancy outcomes, whereas creatinine differences lacked clinical impact. Full article