Open AccessSystematic Review
Racial Disparities in Respiratory Syncytial Virus Vaccination in Pregnant Black Women: A Rapid Literature Review
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Gustavo Gonçalves dos Santos, Débora de Souza Santos, Reginaldo Roque Mafetoni, Clara Fróes de Oliveira Sanfelice, Janize Silva Maia, Karina Franco Zihlmann, Ricardo José Oliveira Mouta, Cindy Ferreira Lima, Patrícia Wottrich Parenti, Joaquim Guerra de Oliveira Neto, Wágnar Silva Morais Nascimento, Telma Maria Evangelista de Araújo, Cesar Henrique Rodrigues Reis, Carolliny Rossi de Faria Ichikawa, Júlia Maria das Neves Carvalho, Ana Cristina Ribeiro da Fonseca Dias, Maria Luísa Santos Bettencourt and Maria João Jacinto Guerra
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Abstract
Respiratory Syncytial Virus infection is a significant cause of morbidity and mortality in infants. Maternal vaccination with the bivalent vaccine Abrysvo
® in the third trimester (24–36 weeks) is an effective strategy to prevent severe respiratory illnesses in newborns. However, the introduction of
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Respiratory Syncytial Virus infection is a significant cause of morbidity and mortality in infants. Maternal vaccination with the bivalent vaccine Abrysvo
® in the third trimester (24–36 weeks) is an effective strategy to prevent severe respiratory illnesses in newborns. However, the introduction of this new technology faces structural obstacles that amplify inequalities. This rapid literature review sought to map and synthesize evidence on inequalities and inequities in adherence and accessibility to maternal vaccination among Black pregnant women. A rapid literature review was conducted using a mixed-methods approach (narrative synthesis and thematic analysis), following guidelines adapted from the Preferred Reporting Items for Systematic Reviews and Meta-Analyses and the Cochrane Handbook. The research question was structured using the acronym Population/Problem, Exposure, Comparison, and Outcome, focusing on Black pregnant women, maternal vaccination, comparison with other groups, and barriers/determinants. The search was conducted in databases such as PubMed (via Medical Literature Analysis and Retrieval System Online), Scopus and Literatura Latino-Americana e do Caribe em Ciências da Saúde, covering studies published between 2022 and 2025 that presented disaggregated analysis by race. The analysis and interpretation of the findings were guided by Critical Race Theory. The analysis of the twelve included studies (mainly from the United States, the United Kingdom, and Brazil) revealed systematic and robust disparities. Black pregnant women had lower vaccination coverage and were less likely to receive timely recommendations compared to White pregnant women. The barriers identified include: institutional distrust (resulting from structural racism), poor access to prenatal care, inadequate communication, and socioeconomic factors. Inequities are structural and multifactorial phenomena. To ensure that the benefits of the vaccine are distributed equitably, strategies such as anti-racist training for healthcare teams, active vaccination outreach, and continuous monitoring of data disaggregated by race are essential.
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