Review Reports - The Computer Simulation for Triggering Anxiety in Panic Disorder Patients Modulates the EEG Alpha Power during an Oddball Task

Round 1

Reviewer 1 Report

Despite the fact that the study is of undoubted interest, the results of the work contain exclusively comparative data in the form of diagrams and do not contain any examples of original EEG recordings after filtering (those alpha rhythm extraction) for different groups of subjects, nor power spectra. It is also not clear how the reaction times during the oddball task are specifically defined. t is necessary to present these additional results in order to better understand how they were obtained. The number of diagrams can be reduced and the results summarized in a table

Author Response

May 12, 2022.

Editorial Office – NeuroSci

Dear Editor-in-Chief,

We thank the reviewers and Editor for their comments. We review and adjustment according reviewer comments.

We have detailed our responses in consideration of the reviewer’s comments and we have noted all appropriate changes to the text.

I am resubmit the revised manuscript entitled “The computer simulation for trigger anxiety in Panic Disorder patients modulates the EEG alpha power during an oddball task” for possible publication in the NeuroSci. I would like to disclose the following information about reviewer’s comments:

Comments:

Reviewer 2: 1) Check for typos and syntax errors throughout the manuscript. 2) The discussion could be shortened. 3) I suggest authors describe the disorder associated with Panic Disorder like anxiety disorder and unexpected and repeated episodes of intense fear accompanied by physical symptoms that may include chest pain, heart palpitations, shortness of breath, dizziness, or abdominal distress. The authors need to discuss this with appropriate references. 4) Also, I suggest the authors provide the standards followed for EEG alpha power analysis like food style and body weight, and age of the candidates studied here. 5) In methods, the author needs to include more geographical information about the candidates involved in this study. 6) Are the authors found any regional specific differences, if so please include them in the results?

Reply: We appreciate the reviewer’s comment on this point. Dear reviewer, we greatly appreciate your contributions. Thank you for your expert opinion about the manuscript, and your suggestions are extremely important and we will look into it in future studies, thanks for the insights. We include this question in our study.

Reviewer 1: Despite the fact that the study is of undoubted interest, the results of the work contain exclusively comparative data in the form of diagrams and do not contain any examples of original EEG recordings after filtering (those alpha rhythm extraction) for different groups of subjects, nor power spectra. It is also not clear how the reaction times during the oddball task are specifically defined. t is necessary to present these additional results in order to better understand how they were obtained. The number of diagrams can be reduced and the results summarized in a table.

Reply: Dear Reviewer, thank very much. We really appreciate your comments and we review and adjustment according to comments. However, in order to give better visibility and easy analysis of the data we chose to keep the graphs.

More one time, we thank by the considerations and we grateful for the opportunity to submit the manuscript.

Sincerely,

Victor Marinho

Author Response File: Author Response.pdf

Reviewer 2 Report

The study performed by Giorgio Silva et al. the title of the manuscript is The computer simulation for trigger anxiety in Panic Disorder 2 patients modulates the EEG alpha power during an oddball 3 task.

This is a very interesting study and investigated the differences between the Panic Disorder (PD) patients groups' and healthy controls for the EEG alpha dynamics under the frontal cortex and reaction time during the oddball task.

Even though this study is interesting but the following comments need to be addressed to strengthen the manuscript.

Check for typos and syntax errors throughout the manuscript.

The discussion could be shortened.

I suggest authors describe the disorder associated with Panic Disorder like anxiety disorder and unexpected and repeated episodes of intense fear accompanied by physical symptoms that may include chest pain, heart palpitations, shortness of breath, dizziness, or abdominal distress. The authors need to discuss this with appropriate references.

Also, I suggest the authors provide the standards followed for EEG alpha power analysis like food style and body weight, and age of the candidates studied here.

In methods, the author needs to include more geographical information about the candidates involved in this study.

What is the rationale for choosing EEG alpha dynamics in the frontal cortex?

Are the authors found any regional specific differences, if so please include them in the results?