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Volume 84
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10.5603/PiAP.a2015.0080
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Advances in Respiratory Medicine is published by MDPI from Volume 90 Issue 4 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Via Medica.
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Article

Serum Levels of Apoptosis-Related Markers (sFasL, TNF-α, p53 and bcl-2) in COPD Patients

by
Monika Kosacka
1,*,
Irena Porębska
1,
Anna Korzeniewska
1,
Renata Rubinsztajn
2,
Marcin Grabicki
3,
Renata Jankowska
1,
Halina Batura-Gabryel
3 and
Ryszarda Chazan
2
1
Chair and Department of Pulmonology and Lung Cancer, Wroclaw Medical University, ul. Grabiszynska 105, 53-439 Wroclaw, Poland
2
Department of Internal Diseases, Pneumonology and Allergology, Medical University of Warsaw, Wroclaw, Poland
3
Department of Pulmonology, Allergology and Respiratory Oncology, University of Medical Sciences, Poznan, Poland
*
Author to whom correspondence should be addressed.
Adv. Respir. Med. 2016, 84(1), 11-15; https://doi.org/10.5603/PiAP.a2015.0080
Submission received: 2 August 2015 / Revised: 14 October 2015 / Accepted: 30 October 2015 / Published: 21 December 2015

Abstract

Introduction: Taking into account important role of apoptosis in COPD pathogenesis, we wanted to asses the serum levels of markers involved in apoptosis regulation, including apoptosis inducers such as TNF-α, sFasL or p53 protein and apoptosis inhibitor bcl-2 and, in addition, to compare these markers with selected COPD parameters. Material and methods: In 181 patients (60 women) with COPD (age was 62.2 + 9.37 years; FEV1% 55.2 + 19.98 %) and in 29 controls (11 women), serum levels of TNF-α, sFasL, p53 and bcl-2 were evaluated by the enzyme-linked immunosorbent assay (ELISA) method. Results: In COPD patients the mean sFasL level was 0.092 ± 0.077 ng/mL and mean TNF-α level was 2.911 ± 3.239 pg/mL. There were no differences in serum sFasL and TNF-α in COPD patients and control group. TNF-α and sFasL did not correlate with COPD parameters such as FEV1%, BMI, RV% (percentage of predicted value of residual volume) or BODE. Although we tried to evaluate bcl-2 and p53 protein serum levels with two different tests, measurable levels of bcl-2 were only detected in 15 patients and p53 in only 3 patients. Bcl-2 values were from 0.418 to 11.423 ng/mL and p53 from 90.772 to 994.749 pg/mL. Conclusions: We didn’t observe any differences in serum levels of pro- and antiapoptotic markers in COPD patients and the control group or correlations between the markers studied and COPD parameters.
Keywords: apoptosis; bcl-2; COPD; p53; sFasL; TNF-α apoptosis; bcl-2; COPD; p53; sFasL; TNF-α

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MDPI and ACS Style

Kosacka, M.; Porębska, I.; Korzeniewska, A.; Rubinsztajn, R.; Grabicki, M.; Jankowska, R.; Batura-Gabryel, H.; Chazan, R. Serum Levels of Apoptosis-Related Markers (sFasL, TNF-α, p53 and bcl-2) in COPD Patients. Adv. Respir. Med. 2016, 84, 11-15. https://doi.org/10.5603/PiAP.a2015.0080

AMA Style

Kosacka M, Porębska I, Korzeniewska A, Rubinsztajn R, Grabicki M, Jankowska R, Batura-Gabryel H, Chazan R. Serum Levels of Apoptosis-Related Markers (sFasL, TNF-α, p53 and bcl-2) in COPD Patients. Advances in Respiratory Medicine. 2016; 84(1):11-15. https://doi.org/10.5603/PiAP.a2015.0080

Chicago/Turabian Style

Kosacka, Monika, Irena Porębska, Anna Korzeniewska, Renata Rubinsztajn, Marcin Grabicki, Renata Jankowska, Halina Batura-Gabryel, and Ryszarda Chazan. 2016. "Serum Levels of Apoptosis-Related Markers (sFasL, TNF-α, p53 and bcl-2) in COPD Patients" Advances in Respiratory Medicine 84, no. 1: 11-15. https://doi.org/10.5603/PiAP.a2015.0080

APA Style

Kosacka, M., Porębska, I., Korzeniewska, A., Rubinsztajn, R., Grabicki, M., Jankowska, R., Batura-Gabryel, H., & Chazan, R. (2016). Serum Levels of Apoptosis-Related Markers (sFasL, TNF-α, p53 and bcl-2) in COPD Patients. Advances in Respiratory Medicine, 84(1), 11-15. https://doi.org/10.5603/PiAP.a2015.0080

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