Batch and Flow Asymmetric Catalysis for the Synthesis of Chiral Active Pharmaceutical Compounds ^†

Continuous-flow systems have emerged as a powerful technology for performing chemical transformations and have recently attracted attention also for the preparation of chiral APIs (active pharmaceutical ingredients).

Recently developed technology-assisted stereoselective reactions will be discussed, including reactions of nitroacrylates under MW irradiation and organocatalyzed reactions in alternative reaction media (Deep Eutectic Solvents). Some stereoselective transformations have been performed in chiral organocatalytic reactors (packed-bed and monolithic) under continuous flow conditions. Recent developments will be presented, also highlighting the possibility to perform organocatalytic reactions in (micro)-mesoreactors and to synthesize in flow-mode chiral intermediates of pharmaceutical interest. Preliminary results of stereoselective catalytic reactions in 3D-printed reactors will also be briefly highlighted.