International Journal of Neonatal Screening, Volume 9, Issue 1
2023 March - 15 articles
Cover Story: Maternal vitamin B12 deficiency can cause developmental delay in breastfed infants. Early detection using newborn screening has improved by introducing first-tier markers from both B12-dependent pathways followed by second-tier methylmalonic acid and homocysteine analyses. Early diagnosis prevents symptoms of B12 deficiency, treatment is inexpensive and efficient, and maternal health and future offspring are added benefits. Nevertheless, despite the implementation of systematic algorithms, specificity and sensitivity remain suboptimal for identifying neonatal B12 deficiency or newborns prone to B12 deficiency later in infancy. Screening of maternal B12 deficiency in pregnancy is suggested as a complementary approach to newborn screening. View this paper
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Int. J. Neonatal Screen. - ISSN 2409-515X