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Tomography, Volume 7, Issue 1

March 2021 - 8 articles

Cover Story: Pre-treatment prediction of disease-free survival in laryngeal and hypopharyngeal cancer patients after definitive treatment can be helpful in determining prognosis and in considering escalated therapeutic options. Our predictive model in 36 patients evaluated 26 CT radiomic features and 5 CT perfusion features and showed that the change in blood flow had a training AUC of 0.68 (CI 0.47–0.85) and testing AUC of 0.66 (CI 0.47–0.85). The best features selected were a combination of blood flow and computer-estimated percent volume changes that had a training AUC of 0.68 (CI 0.5–0.85) and testing AUC of 0.69 (CI 0.5–0.85). A combination of CT perfusion and radiomic features is therefore a potential predictor of 1-year disease-free survival in laryngeal and hypopharyngeal cancer patients. View this paper.
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Articles (8)

  • Review
  • Open Access
9 Citations
7,161 Views
15 Pages

Dynamic Contrast Enhanced-MR CEST Urography: An Emerging Tool in the Diagnosis and Management of Upper Urinary Tract Obstruction

  • Shaowei Bo,
  • Farzad Sedaghat,
  • KowsalyaDevi Pavuluri,
  • Steven P. Rowe,
  • Andrew Cohen,
  • Max Kates and
  • Michael T. McMahon

Upper urinary tract obstructions (UTOs) are blockages that inhibit the flow of urine through its normal course, leading to impaired kidney function. Imaging plays a significant role in the initial diagnosis of UTO, with anatomic imaging (primarily ul...

  • Article
  • Open Access
5 Citations
3,245 Views
14 Pages

Respiratory Motion Mitigation and Repeatability of Two Diffusion-Weighted MRI Methods Applied to a Murine Model of Spontaneous Pancreatic Cancer

  • Jianbo Cao,
  • Hee Kwon Song,
  • Hanwen Yang,
  • Victor Castillo,
  • Jinbo Chen,
  • Cynthia Clendenin,
  • Mark Rosen,
  • Rong Zhou and
  • Stephen Pickup

20 February 2021

Respiratory motion and increased susceptibility effects at high magnetic fields pose challenges for quantitative diffusion-weighted MRI (DWI) of a mouse abdomen on preclinical MRI systems. We demonstrate the first application of radial k-space-sample...

  • Article
  • Open Access
9 Citations
3,580 Views
10 Pages

Identifying Robust Radiomics Features for Lung Cancer by Using In-Vivo and Phantom Lung Lesions

  • Lin Lu,
  • Shawn H. Sun,
  • Aaron Afran,
  • Hao Yang,
  • Zheng Feng Lu,
  • James So,
  • Lawrence H. Schwartz and
  • Binsheng Zhao

9 February 2021

We propose a novel framework for determining radiomics feature robustness by considering the effects of both biological and noise signals. This framework is preliminarily tested in a study predicting the epidermal growth factor receptor (EGFR) mutati...

  • Article
  • Open Access
1 Citations
3,558 Views
16 Pages

A System-Agnostic, Adaptable and Extensible Animal Support Cradle System for Cardio-Respiratory-Synchronised, and Other, Multi-Modal Imaging of Small Animals

  • Veerle Kersemans,
  • Stuart Gilchrist,
  • Philip Danny Allen,
  • Sheena Wallington,
  • Paul Kinchesh,
  • John Prentice,
  • Martin Tweedie,
  • Jamie H. Warner and
  • Sean C. Smart

7 February 2021

Standardisation of animal handling procedures for a wide range of preclinical imaging scanners will improve imaging performance and reproducibility of scientific data. Whilst there has been significant effort in defining how well scanners should oper...

  • Article
  • Open Access
13 Citations
4,773 Views
19 Pages

Systematic Assessment of the Impact of DTI Methodology on Fractional Anisotropy Measures in Alzheimer’s Disease

  • Maurizio Bergamino,
  • Elizabeth G. Keeling,
  • Ryan R. Walsh and
  • Ashley M. Stokes

6 February 2021

White matter microstructural changes in Alzheimer’s disease (AD) are often assessed using fractional anisotropy (FA) obtained from diffusion tensor imaging (DTI). FA depends on the acquisition and analysis methods, including the fitting algorithm. In...

  • Article
  • Open Access
6 Citations
3,935 Views
9 Pages

Design and Implementation of the Pre-Clinical DICOM Standard in Multi-Cohort Murine Studies

  • Joseph D. Kalen,
  • David A. Clunie,
  • Yanling Liu,
  • James L. Tatum,
  • Paula M. Jacobs,
  • Justin Kirby,
  • John B. Freymann,
  • Ulrike Wagner,
  • Kirk E. Smith and
  • Christian Suloway
  • + 1 author

5 February 2021

The small animal imaging Digital Imaging and Communications in Medicine (DICOM) acquisition context structured report (SR) was developed to incorporate pre-clinical data in an established DICOM format for rapid queries and comparison of clinical and...

  • Article
  • Open Access
11 Citations
3,285 Views
10 Pages

Prediction of Disease Free Survival in Laryngeal and Hypopharyngeal Cancers Using CT Perfusion and Radiomic Features: A Pilot Study

  • Sean Woolen,
  • Apurva Virkud,
  • Lubomir Hadjiiski,
  • Kenny Cha,
  • Heang-Ping Chan,
  • Paul Swiecicki,
  • Francis Worden and
  • Ashok Srinivasan

5 February 2021

(1) Purpose: The objective was to evaluate CT perfusion and radiomic features for prediction of one year disease free survival in laryngeal and hypopharyngeal cancer. (2) Method and Materials: This retrospective study included pre and post therapy CT...

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Tomography - ISSN 2379-139X