Tomography, Volume 11, Issue 11 (November 2025) – 2 articles

Objective: This study aims to assess the prevalence of clinically significant incidental findings as well as incidental findings of minor clinical significance in multiparametric MRI (mpMRI) of the prostate. Materials and Methods: A retrospective analysis was conducted on 607 male patients (mean age: 72 years) who underwent prostate MRI between 2018 and 2023 at a single center. Two radiologists reviewed in consensus the scans for incidental findings during multiparametric MRI of the prostate. The findings were classified according to their clinical relevance, organ group and patient age. Results: Among 607 male patients (mean age: 72 years), 665 incidental findings were identified in 410 patients (67.5%; 95% CI 63.7–71.1). This corresponds to an average of 1.10 incidental findings per patient across the entire cohort. Of the 665 findings, 12 (1.8%; 95% CI 0.9–3.1) were classified as clinically significant. These included cases of sarcoma, rectal carcinoma, hydronephrosis, aortic aneurysm, avascular necrosis of the femoral head and high-grade disc protrusion with spinal canal stenosis and diverticulitis. Conclusions: Our data indicate that incidental findings are common in prostate mpMRI examinations; however, only a small proportion are clinically significant. This underscores the need for awareness of such findings, while avoiding unnecessary follow-up for those without clinical relevance. Full article

Background/Objectives: Cerebral blood flow (CBF) and cerebral blood volume (CBV) are critical perfusion metrics in diagnosing ischemic stroke. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) enables the evaluation of these cerebral perfusion metrics; however, accurately assessing them remains challenging. This study aimed to: (1) assess CBF asymmetry by quantifying and comparing it between contralateral hemispheres (right vs. left) within the MCA, ACA, and PCA territories using paired t-tests, and describe pattern of CBV; (2) evaluate overall inter-territorial regional variations in CBF across the different cerebral arterial territories (MCA, ACA, PCA), irrespective of the hemisphere, using ANOVA; (3) determine the correlation between CBF and CBV using both Pearson’s and Spearman’s correlation analyses; and (4) assess the influence of age and gender on CBF using multiple regression analysis. Methods: A cross-sectional study of 55 ischemic stroke patients was conducted. DCE-MRI was used to measure CBF and CBV. Paired t-tests compared contralateral hemispheric CBF in MCA, PCA, and ACA, one-way ANOVA assessed overall inter-territorial CBF variations, correlation analyses (Pearson/Spearman) evaluated the CBF-CBV relationship, and linear regression modeled demographic effects. Results: Significant contralateral asymmetries in CBF were observed for each cerebral pair of cerebral arteries using a paired t-test, with descriptive asymmetries noted in CBV. Separately, ANOVA revealed significant overall variability in CBF between the different cerebral arteries, irrespective of hemisphere. A strong positive correlation was found between CBF and CBV (Pearson r = 0.976; Spearman r = 0.928), with multiple regression analysis identifying age and gender as significant predictors of CBF. Conclusions: This study highlights hemispheric asymmetry and inter-territorial variation, the impact of age, and gender on CBF. DCE-MRI provides perfusion metrics that can guide individualized stroke treatment, offering valuable insights for therapeutic planning, particularly in resource-limited settings. Full article