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Gels, Volume 8, Issue 4

April 2022 - 52 articles

Cover Story: Lower back pain due to intervertebral disc (IVD) degeneration is a major contributor to global disability, and leads to progressive extracellular matrix degradation, chronic inflammation and pain. Current treatments are inefficient and invasive. Alternative tissue engineering strategies, in which biomaterials are used as injectable carriers of cells and/or biomolecules to restore tissue function and aid regeneration, are being explored. Among these, self-assembling peptide hydrogels represent a promising class of de novo synthetic biomaterials able to merge the strengths of both natural and synthetic hydrogels to achieve higher functionality. In particular, peptide-based hydrogels’ shear-thinning behaviour, high biocompatibility, tissue mimicry and tuneable physiochemical properties make them a versatile 3D tool with potential to tackle and tame IVD degeneration. View this paper
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Articles (52)

  • Review
  • Open Access
34 Citations
4,698 Views
14 Pages

12 April 2022

Ionizing radiation and its applications are widely spread throughout life. Similar to many other things, both the positive and negative aspects of ionizing radiation should always be kept in mind. For example, a proper radiation dose can be delivered...

  • Article
  • Open Access
29 Citations
5,994 Views
29 Pages

Characterization of Tuna Gelatin-Based Hydrogels as a Matrix for Drug Delivery

  • Carolina Hermida-Merino,
  • David Cabaleiro,
  • Luis Lugo,
  • Jesus Valcarcel,
  • Jose Antonio Vázquez,
  • Ivan Bravo,
  • Alessandro Longo,
  • Georges Salloum-Abou-Jaoude,
  • Eduardo Solano and
  • Carlos Gracia-Fernández
  • + 2 authors

12 April 2022

The skin of yellowfin tuna is one of the fishery industry solid residues with the greatest potential to add extra value to its circular economy that remains yet unexploited. Particularly, the high collagen content of fish skin allows generating gelat...

  • Article
  • Open Access
2 Citations
2,542 Views
16 Pages

12 April 2022

Soft nanomaterials like aerogels are subject to thermal fluctuations, so that their structure randomly fluctuates with time. Neutron elastic and inelastic scattering experiments provide unique structural and dynamic information on such systems with n...

  • Article
  • Open Access
23 Citations
4,186 Views
20 Pages

Preparation and Characterization of a Novel Mucoadhesive Carvedilol Nanosponge: A Promising Platform for Buccal Anti-Hypertensive Delivery

  • El-Sayed Khafagy,
  • Amr S. Abu Lila,
  • Nahed Mohamed Sallam,
  • Rania Abdel-Basset Sanad,
  • Mahgoub Mohamed Ahmed,
  • Mamdouh Mostafa Ghorab,
  • Hadil Faris Alotaibi,
  • Ahmed Alalaiwe,
  • Mohammed F. Aldawsari and
  • Saad M. Alshahrani
  • + 4 authors

11 April 2022

Carvedilol (CRV) is a non-selective third generation beta-blocker used to treat hypertension, congestive heart failure and angina pectoris. Oral administration of CRV showed poor bioavailability (25%), which might be ascribed to its extensive first-p...

  • Article
  • Open Access
11 Citations
3,958 Views
16 Pages

11 April 2022

Surfactants are ubiquitous materials that are used in diverse formulations of various products. For instance, they improve the formulation of gel by improving its wetting and rheological properties. Here, we describe the effects of anionic surfactant...

  • Article
  • Open Access
13 Citations
4,700 Views
14 Pages

Circular Economy of Coal Fly Ash and Silica Geothermal for Green Geopolymer: Characteristic and Kinetic Study

  • Himawan Tri Bayu Murti Petrus,
  • Muhammad Olvianas,
  • Muhammad Faiz Shafiyurrahman,
  • I Gusti Agung Arvin Nanda Pratama,
  • Siti Nurul Aisyiyah Jenie,
  • Widi Astuti,
  • Muhammad Istiawan Nurpratama,
  • Januarti Jaya Ekaputri and
  • Ferian Anggara

11 April 2022

The study of geopolymers has become an interesting concern for many scientists, especially in the infrastructure sector, due to having inherently environmentally friendly properties and fewer energy requirements in production processes. Geopolymer at...

  • Review
  • Open Access
17 Citations
4,494 Views
17 Pages

Targeted Cancer Therapy via pH-Functionalized Nanoparticles: A Scoping Review of Methods and Outcomes

  • Stefan Morarasu,
  • Bianca Codrina Morarasu,
  • Razvan Ghiarasim,
  • Adina Coroaba,
  • Crina Tiron,
  • Radu Iliescu and
  • Gabriel-Mihail Dimofte

11 April 2022

(1) Background: In recent years, several studies have described various and heterogenous methods to sensitize nanoparticles (NPs) to pH changes; therefore, in this current scoping review, we aimed to map current protocols for pH functionalization of...

  • Article
  • Open Access
20 Citations
3,778 Views
19 Pages

Design and Comparative Evaluation of Vancomycin HCl-Loaded Rosin-Based In Situ Forming Gel and Microparticles

  • Tiraniti Chuenbarn,
  • Jitnapa Sirirak,
  • Sarun Tuntarawongsa,
  • Siriporn Okonogi and
  • Thawatchai Phaechamud

8 April 2022

Vancomycin hydrochloride (HCl) is a glycopeptide antibiotic used to treat serious or life-threatening infections, and it reduces plaque scores and gingivitis in periodontal patients. In this study, vancomycin HCl was incorporated into rosin in situ f...

  • Article
  • Open Access
14 Citations
4,183 Views
33 Pages

7 April 2022

The rheology, i.e., the flow and deformation properties, of hydrogels is generally a very important consideration for their functionality. However, the accurate characterization of their rheological material functions is handicapped by their ubiquito...

  • Article
  • Open Access
5 Citations
3,213 Views
16 Pages

Influence of Levan on the Thermally Induced Gel Formation of β-Lactoglobulin

  • Christoph S. Hundschell,
  • Juliane Brühan,
  • Theresa Anzmann,
  • Reinhard Kohlus and
  • Anja M. Wagemans

7 April 2022

In this study, the influence of levan on the phase behavior and the thermally induced gelation of the mixed β-lactoglobulin—levan gels as a function of polymer content, molecular weight and ionic strength was characterized. For this purpos...

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Gels - ISSN 2310-2861