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Gels, Volume 8, Issue 4

April 2022 - 52 articles

Cover Story: Lower back pain due to intervertebral disc (IVD) degeneration is a major contributor to global disability, and leads to progressive extracellular matrix degradation, chronic inflammation and pain. Current treatments are inefficient and invasive. Alternative tissue engineering strategies, in which biomaterials are used as injectable carriers of cells and/or biomolecules to restore tissue function and aid regeneration, are being explored. Among these, self-assembling peptide hydrogels represent a promising class of de novo synthetic biomaterials able to merge the strengths of both natural and synthetic hydrogels to achieve higher functionality. In particular, peptide-based hydrogels’ shear-thinning behaviour, high biocompatibility, tissue mimicry and tuneable physiochemical properties make them a versatile 3D tool with potential to tackle and tame IVD degeneration. View this paper
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Articles (52)

  • Article
  • Open Access
8 Citations
3,234 Views
14 Pages

Properties of Cellulose Pulp and Polyurethane Composite Films Fabricated with Curcumin by Using NMMO Ionic Liquid

  • Chaehyun Jo,
  • Sam Soo Kim,
  • Balasubramanian Rukmanikrishnan,
  • Srinivasan Ramalingam,
  • Prabakaran D. S. and
  • Jaewoong Lee

18 April 2022

Cellulose pulp (CP), polyurethane (PU), and curcumin-based biocompatible composite films were prepared using a simple cost-effective method. Significant structural and microstructural changes were studied using FT-IR spectroscopy, XRD, and SEM. The 5...

  • Review
  • Open Access
39 Citations
7,758 Views
12 Pages

18 April 2022

This brief review attempts to summarize research advances in the mechanical toughness and structures of double-network (DN) hydrogels. The focus is to provide a critical and concise discussion on the toughening mechanisms, damage recoverability, stre...

  • Article
  • Open Access
29 Citations
9,607 Views
15 Pages

Graphene Oxide-Reinforced Alginate Hydrogel for Controlled Release of Local Anesthetics: Synthesis, Characterization, and Release Studies

  • Cuong Hung Luu,
  • Giang Nguyen,
  • Thanh-Tuyen Le,
  • Thanh-Mai Ngoc Nguyen,
  • V. H. Giang Phan,
  • Mohanapriya Murugesan,
  • Ramya Mathiyalagan,
  • Lu Jing,
  • Gopinathan Janarthanan and
  • Deok Chun Yang
  • + 2 authors

16 April 2022

In pain relief, lidocaine has gained more attention as a local anesthetic. However, there are several side effects that limit the use of local anesthetics. Therefore, it is hypothesized that a hydrogel system with facile design can be used for prolon...

  • Article
  • Open Access
27 Citations
5,362 Views
21 Pages

15 April 2022

Fusidic acid (FA) is renowned as an effective bacteriostatic agent obtained from the fungus Fusidium coccineum, used for treating various eye and skin disorders. The objective of the present study was to develop, characterize, and evaluate the antiba...

  • Article
  • Open Access
19 Citations
4,635 Views
12 Pages

A Supramolecular Hydrogel Enabled by the Synergy of Hydrophobic Interaction and Quadruple Hydrogen Bonding

  • Liangmei Lu,
  • Wen Zhou,
  • Zhuzuan Chen,
  • Yang Hu,
  • Yu Yang,
  • Guangzhao Zhang and
  • Zhuohong Yang

14 April 2022

The increasing preference for minimally invasive surgery requires novel soft materials that are injectable, with rapid self-healing abilities, and biocompatible. Here, by utilizing the synergetic effect of hydrophobic interaction and quadruple hydrog...

  • Feature Paper
  • Article
  • Open Access
11 Citations
3,199 Views
16 Pages

14 April 2022

This study investigates the effects of different pressures (200, 250, 300, 350, and 400 MPa) and durations (5, 10, 15, 20, and 25 min) on the functional properties, secondary structure, and intermolecular forces of cowhide gelatin. Our results show t...

  • Article
  • Open Access
25 Citations
4,104 Views
15 Pages

14 April 2022

AZ31B Mg alloys were anodized at different potentials using an alkaline electrolyte. Then, an epoxy-alkyl silane sol reinforced with SiO2 nanoparticles was prepared by sol–gel and deposited on top of the optimized anodic layers. 1-Methyl imidaz...

  • Article
  • Open Access
31 Citations
4,821 Views
16 Pages

Development and Optimization of Hyaluronic Acid-Poloxamer In-Situ Gel Loaded with Voriconazole Cubosomes for Enhancement of Activity against Ocular Fungal Infection

  • Nabil A. Alhakamy,
  • Khaled M. Hosny,
  • Waleed Y. Rizg,
  • Bayan A. Eshmawi,
  • Moutaz Y. Badr,
  • Awaji Y. Safhi and
  • Samar S. A. Murshid

14 April 2022

Fungal eye infections are largely disseminated, especially in developing countries where they may leave over half a million people blind per year. The current study aims to boost the voriconazole antifungal efficiency via loading it as cubosomes (VZ-...

  • Article
  • Open Access
32 Citations
3,980 Views
20 Pages

13 April 2022

Chitosan (CS)-based drug delivery systems (DDSs) are often stabilized by chemical cross-linking. A much more friendly approach to deliver drugs in a controlled manner is represented by polyelectrolyte complexes (PECs) physically stabilized by spontan...

  • Review
  • Open Access
17 Citations
5,970 Views
42 Pages

A Comprehensive Assessment on the Pivotal Role of Hydrogels in Scaffold-Based Bioprinting

  • Matangi Parimala Chelvi Ratnamani,
  • Xinping Zhang and
  • Hongjun Wang

13 April 2022

The past a few decades have seen exponential growth in the field of regenerative medicine. What began as extirpative (complete tissue or organ removal), with little regard to the effects of tissue loss and/or disfigurement, has evolved towards fabric...

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Gels - ISSN 2310-2861