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Gels, Volume 12, Issue 7 (July 2026) – 97 articles

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19 pages, 5380 KB  
Review
Soft Iontronic Diodes: Materials, Mechanisms, and Progress
by Liang Li, Qinchen Meng and Li Wang
Gels 2026, 12(7), 656; https://doi.org/10.3390/gels12070656 - 22 Jul 2026
Viewed by 326
Abstract
Soft iontronic devices, which utilize ions as charge carriers and integrate flexibility and stretchability, exhibit diverse carrier species, high biocompatibility, multimodal stimulus responsiveness, and strong resistance to electromagnetic interference. These features make them highly promising for applications in ionic circuits, flexible sensing, implantable [...] Read more.
Soft iontronic devices, which utilize ions as charge carriers and integrate flexibility and stretchability, exhibit diverse carrier species, high biocompatibility, multimodal stimulus responsiveness, and strong resistance to electromagnetic interference. These features make them highly promising for applications in ionic circuits, flexible sensing, implantable systems, and neuromorphic information processing. Among them, soft iontronic diodes have attracted sustained attention over the past two decades as fundamental building blocks of functional circuits. This review systematically summarizes the material types of soft iontronic diodes and their influence on key device performance. It further elucidates the mechanisms underlying ionic rectification and highlights recent advances in logic gate implementation, energy harvesting, flexible sensing, and neuromorphic computing. Finally, we discuss key challenges and future opportunities in this field, aiming to provide design principles and mechanistic insights for the development and application of soft iontronic diodes. Full article
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31 pages, 1327 KB  
Review
Hyaluronic Acid-Based Biomaterials for Soft Tissue Repair and Wound Healing: Clinical Evidence and Emerging Applications
by Bogdan Mircea Măciuceanu Zărnescu, Diana Cristina Pîrvulescu (Bunea), Adelina-Gabriela Niculescu, Alexandru Scafa Udriște, Alexandru Mihai Grumezescu and Sebastian Vâlcea
Gels 2026, 12(7), 655; https://doi.org/10.3390/gels12070655 - 22 Jul 2026
Viewed by 493
Abstract
Hyaluronic acid (HA) is a glycosaminoglycan that is found within the body and has both structural and signaling functions in the extracellular matrix. HA is biocompatible and biodegradable; it has a high water content and binds directly to certain cell-surface proteins. Due to [...] Read more.
Hyaluronic acid (HA) is a glycosaminoglycan that is found within the body and has both structural and signaling functions in the extracellular matrix. HA is biocompatible and biodegradable; it has a high water content and binds directly to certain cell-surface proteins. Due to these characteristics, it is considered a promising component for the design of biomaterials for regenerative wound healing. This review covers the most recent findings on the use of HA-based biomaterials in soft tissue repair, while also incorporating earlier, foundational studies relevant to the field, focusing on HA’s characteristics, cellular interactions, design, and preclinical and clinical results. The physicochemical characteristics of HA and their influence on cellular responses and tissue regeneration are discussed to show how material properties can be adjusted for specific therapeutic purposes. There have been great advances in chemically modified composite scaffolds and HA matrices, which offer better mechanical stability and controlled degradation. At the same time, new delivery systems have been built using HA, from nanoparticles to gene delivery platforms and growth factors, and these have given the material an active role as a therapeutic agent rather than just a passive one. This narrative review covers the clinical evidence for the effectiveness of commercial products for acute and diabetic wounds, as well as burns and chronic wounds, and discusses where their use is indicated. In the end, the current limitations of the research and future applications and directions are discussed. Full article
(This article belongs to the Special Issue Regenerating and Repairing Gels)
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32 pages, 65176 KB  
Review
Dynamic Silk Fibroin Hydrogels for Programmable Bioactuation and Smart Shape Deformation: Mechanisms, Performance Evaluation, and Biomedical Applications
by Asim Mushtaq, Khai Ly Do, Taswar Ahsan, Shoaib Ashiq, Weizhu An, Miao Su and Muhammad Yousaf
Gels 2026, 12(7), 654; https://doi.org/10.3390/gels12070654 - 21 Jul 2026
Viewed by 653
Abstract
Programmable hydrogel actuators represent an innovative group of adaptive soft matter systems, which are able to respond to external stimuli with controllable mechanical movements for biomedical and bioengineering purposes. Natural silk fibroin (SF) is known to be a peculiar biomaterial, since it can [...] Read more.
Programmable hydrogel actuators represent an innovative group of adaptive soft matter systems, which are able to respond to external stimuli with controllable mechanical movements for biomedical and bioengineering purposes. Natural silk fibroin (SF) is known to be a peculiar biomaterial, since it can exhibit controllable β-sheet-induced structural transitions, hierarchical self-assemblies, high biocompatibility, and mechanical adaptability, thus representing an ideal candidate for the development of dynamic hydrogels. In contrast to earlier reviews which focused more on SF hydrogel synthesis or biomedical applications, this review presents a mechanism-based understanding of programmable bioactuation by carefully correlating molecular design, network formation, stimuli responsiveness, and macroscopic deformation. Recent developments in SF hydrogel actuators are critically compared in terms of actuation principles, deformation behaviors, response dynamics, mechanical robustness, and functionalization, noting the natural compromise between fast response, strength generation, and durability in such materials. Novel concepts like nanocomposite materials, bioinspired designs, shape memory systems, and 4D printing are described as efficient ways to improve programmable deformation and functionality in soft materials. In addition, the biomedical opportunities of responsive SF hydrogels in wound healing, drug delivery, tissue engineering, wearable biosensors, and soft robots are critically discussed in relation to existing barriers for translation into practice. Combining mechanistic understanding with the comparative assessment of the performance of hydrogels is a basis for developing a complete rationale for the design of the next generation of SF hydrogel actuators and smart shape deformations. Full article
(This article belongs to the Special Issue Advanced Hydrogels: Programmable Deformation and Actuation Design)
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12 pages, 567 KB  
Article
In Vitro Release of Curcumin and Resveratrol from Polymeric Systems: Films and Hydrogel
by Ana Júlia Panserini de Goes, Heloisa Januário Ribeiro de Queiroz, Lorena Trezena Sidiropoulos, Ana Lídia Piccolo Vespasiano and Gisele Mara Silva Gonçalves
Gels 2026, 12(7), 653; https://doi.org/10.3390/gels12070653 - 21 Jul 2026
Viewed by 389
Abstract
Chronic wounds are a persistent clinical and public health challenge due to impaired tissue repair caused by sustained inflammation, oxidative stress, and cellular senescence. Natural polyphenols such as curcumin and resveratrol, alongside mesenchymal stem cell (MSC) secretome, have demonstrated complementary anti-inflammatory, antioxidant, and [...] Read more.
Chronic wounds are a persistent clinical and public health challenge due to impaired tissue repair caused by sustained inflammation, oxidative stress, and cellular senescence. Natural polyphenols such as curcumin and resveratrol, alongside mesenchymal stem cell (MSC) secretome, have demonstrated complementary anti-inflammatory, antioxidant, and pro-angiogenic properties with potential for wound healing. This study reports two complementary in vitro investigations evaluating the release profiles of curcumin and resveratrol from two polymeric platforms: poly(vinyl alcohol)/sodium alginate/carboxymethylcellulose films (Study 1) and an acrylate copolymer-based hydrogel incorporating MSC secretome (Study 2). UV-Vis spectrophotometric analysis confirmed analytical selectivity with no interference from excipients. Resveratrol exhibited progressive and consistent release from the hydrogel. Curcumin compromised polymer matrix integrity and reduced resveratrol release efficiency. Also showed unsatisfactory release in both systems, attributed to its low aqueous solubility. These results support the use of resveratrol-loaded polymeric matrices as promising sustained-release platforms for bioactive wound dressings and highlight the need for nanoencapsulation strategies to improve curcumin bioavailability. Full article
(This article belongs to the Section Gel Analysis and Characterization)
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21 pages, 24336 KB  
Article
Enzyme-Flavonoid Synergistic Hydrogel: Enables Glucose-Activated Cascade Acidification and Programmed Drug Release for Diabetic Wound Therapy
by Guixi Wang, Sihang Shen, Yichen Tian, Chao Li, Junnan He and Yuzhu Song
Gels 2026, 12(7), 652; https://doi.org/10.3390/gels12070652 - 21 Jul 2026
Viewed by 291
Abstract
Inflammation and oxidative stress induced by high glucose levels constitute essential factors impeding wound healing in diabetes, posing a significant threat to public health. Despite its notable anti-inflammatory and antioxidant potential, the clinical applicability of quercetin is hampered by its hydrophobicity and limited [...] Read more.
Inflammation and oxidative stress induced by high glucose levels constitute essential factors impeding wound healing in diabetes, posing a significant threat to public health. Despite its notable anti-inflammatory and antioxidant potential, the clinical applicability of quercetin is hampered by its hydrophobicity and limited oral bioavailability. To address these issues, the thin-film hydration method was used to encapsulate quercetin into FQ micelles. Subsequently, 3-aminophenylboronic acid-modified oxidized alginate was crosslinked with polyvinyl alcohol, and simultaneously loaded with glucose oxidase (GOX) and FQ micelles, to construct a glucose-activated cascade acidification-triggered controlled-release hydrogel (OSSP@FQ&GOX). The phenylboronic ester bonds in the hydrogel are responsive to glucose and undergo cleavage. GOX-mediated oxidation of glucose produces gluconic acid, resulting in a lower local pH and subsequently triggering FQ micelle release. The released FQ micelles alleviate oxidative stress and exert immunomodulatory effects, while the hydrogel also provides self-healing, and biocompatible properties that facilitate cutaneous regeneration in diabetic mice. Thus, this study highlights the potential of combining GOX with natural products and multi-stimuli-responsive hydrogels for the treatment of chronic diabetic wounds, while also opening new avenues for the development of multifunctional wound dressings. Full article
(This article belongs to the Special Issue Recent Advances in Gel-Based Materials for Wound Healing)
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22 pages, 4242 KB  
Article
Evaluation of Propolis and Diclofenac Sodium Eye Drops for Animals: Physicochemical Properties and In Vitro Biological Activity
by Dovilė Svetikienė, Vita Ambrulaitienė, Gintarė Jančiukė, Ieva Sarapinienė, Gintaras Zamokas, Aidas Grigonis, Oleksandr O. Nefodov and Kristina Ramanauskienė
Gels 2026, 12(7), 651; https://doi.org/10.3390/gels12070651 - 20 Jul 2026
Viewed by 491
Abstract
Eye diseases are common in veterinary clinical practice and are most often treated with topical ophthalmic preparations. Increasing resistance to antimicrobial agents is driving the search for safe and effective alternatives to traditional treatment methods. The aim of this study was to develop [...] Read more.
Eye diseases are common in veterinary clinical practice and are most often treated with topical ophthalmic preparations. Increasing resistance to antimicrobial agents is driving the search for safe and effective alternatives to traditional treatment methods. The aim of this study was to develop and evaluate gel-based ophthalmic formulations based on poloxamer 407 and sodium carboxymethylcellulose, containing propolis extracts and diclofenac sodium, by assessing their physical and chemical properties, antimicrobial activity, and cytotoxicity in vitro. Propolis extracts were prepared using a solvent consisting of ethanol and choline chloride, and the developed formulations were evaluated for pH, viscosity, refractive index, gelation temperature, SIRC cell viability and apoptosis, and antimicrobial activity against clinical and reference bacterial strains. The developed formulations exhibited physicochemical properties suitable for ophthalmic preparations and antimicrobial activity, particularly against Gram-positive bacteria. Most of the concentrations of the active ingredients tested were well tolerated by SIRC cells, although higher concentrations of the ethanol propolis extract caused a greater cytotoxic effect. The results obtained indicate that gelled ophthalmic formulations based on propolis extracts and diclofenac sodium are promising for the further development of topically acting ophthalmic preparations; however, their biological efficacy and safety must be confirmed. The results obtained indicate that gelled ophthalmic formulations based on propolis extracts and diclofenac sodium are promising for the further development of topical ophthalmic preparations; however, their bioavailability and safety must be confirmed by further in vivo studies. Full article
(This article belongs to the Special Issue Polymer-Based Hydrogels Applied in Drug Delivery)
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50 pages, 42591 KB  
Review
Next-Generation Bio-Based Battery Separators: Current Status and Future Research Opportunities
by Tianyu Hu, Yunxiang Cui, Han Wang, Peiwen Liu and Qun Song
Gels 2026, 12(7), 650; https://doi.org/10.3390/gels12070650 - 20 Jul 2026
Viewed by 455
Abstract
Conventional polyolefin battery separators are limited by inherent deficiencies in thermal stability, electrolyte wettability, and environmental sustainability, which collectively hinder the advancement of high-energy-density energy storage systems. In this context, biomass macromolecular materials, including cellulose, chitin/chitosan, and lignin, have emerged as promising candidates [...] Read more.
Conventional polyolefin battery separators are limited by inherent deficiencies in thermal stability, electrolyte wettability, and environmental sustainability, which collectively hinder the advancement of high-energy-density energy storage systems. In this context, biomass macromolecular materials, including cellulose, chitin/chitosan, and lignin, have emerged as promising candidates for next-generation separators owing to their environmental benefits, exceptional hydrophilicity, and superior thermal resistance. This review systematically evaluates the molecular characteristics of these three biomass systems, alongside core gel-state processing and network-forming processes such as electrospinning, solution casting, nonwoven technology, and hydrogel-assisted film formation. It further highlights their cutting-edge applications in lithium-ion, lithium–sulfur, zinc-ion, and solid-state batteries, emphasizing their behavior as polymer gel electrolytes and gel-derived structural matrices. To overcome key challenges associated with mechanical robustness, interfacial compatibility, and network uniformity, advanced modification strategies are critically discussed, including surface chemical functionalization, multicomponent hybrid composite formulation, and rational three-dimensional structural engineering. Overall, current research evidence demonstrates that rationally designed biomass-based gel networks and membranes can effectively suppress metal dendrite growth, immobilize soluble polysulfide intermediates via supramolecular interactions, and reduce interfacial impedance in solid-state systems, thereby offering a viable pathway toward safer, more sustainable, and commercially competitive high-energy-density batteries. Full article
(This article belongs to the Special Issue Bio-Based Nanomaterials: Structure, Functions and Durability)
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35 pages, 8595 KB  
Review
Structural Engineering of Edible Oleogels: From Molecular Assembly to Functional Food Applications
by Jun An, Feiyan Yang, Liyou Zheng and Tao Yang
Gels 2026, 12(7), 649; https://doi.org/10.3390/gels12070649 - 20 Jul 2026
Viewed by 418
Abstract
Edible oleogels have emerged as promising alternatives to conventional solid fats. They convert liquid oils into semi-solid structures while reducing saturated and trans fatty acid intake. Despite rapid growth in this field, their performance is not governed by a single factor but by [...] Read more.
Edible oleogels have emerged as promising alternatives to conventional solid fats. They convert liquid oils into semi-solid structures while reducing saturated and trans fatty acid intake. Despite rapid growth in this field, their performance is not governed by a single factor but by coupled effects of oil composition, oleogelator properties, intermolecular interactions, and processing history. In recent years, substantial progress has been achieved in understanding the formation mechanisms, structural regulation strategies, and food applications of oleogels. This review systematically summarizes the key factors influencing oleogel formation and performance, including oil phase composition, gelator type and concentration, molecular interactions, and processing parameters. Emerging structural modulation approaches, such as multi-component oleogelators, hybrid biopolymer systems, and advanced processing technologies, are critically discussed with respect to their effects on crystallization behavior, network architecture, rheological properties, thermal stability, and oil-binding capacity. Particular emphasis is placed on the hierarchical structure–function relationships linking molecular assembly and network organization to macroscopic functionality, digestibility, and bioactive compound delivery. Recent applications of oleogels in bakery products, meat analogs, dairy alternatives, confectionery products, and frying systems are also reviewed. Finally, current challenges and future opportunities related to next-generation oleogelators, hierarchical structural regulation, intelligent responsive systems, and industrial-scale manufacturing are discussed. This review provides a comprehensive framework for understanding the structural engineering of edible oleogels and offers insights into the rational design of healthier and more functional lipid-based food systems. Full article
(This article belongs to the Special Issue Advances in Food Gels: Structure, Processing and Applications)
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26 pages, 1663 KB  
Review
Sustainable Cellulose-Based Gels: Synthesis, Chemical Modification, and Biomedical Application
by Bogdan-Marian Tofanica and Elena Ungureanu
Gels 2026, 12(7), 648; https://doi.org/10.3390/gels12070648 - 20 Jul 2026
Viewed by 454
Abstract
The growing demand for sustainable, biocompatible, and non-toxic biomaterials has driven significant advancements in biobased gels for biomedical applications. Among these, cellulose—the most abundant renewable biopolymer—presents an ideal platform due to its inherent hydrophilicity, structural tunability, and biodegradability. This review reports the recent [...] Read more.
The growing demand for sustainable, biocompatible, and non-toxic biomaterials has driven significant advancements in biobased gels for biomedical applications. Among these, cellulose—the most abundant renewable biopolymer—presents an ideal platform due to its inherent hydrophilicity, structural tunability, and biodegradability. This review reports the recent advancements in the processing and engineering of cellulose-based hydrogels for drug delivery systems. We systematically explore the primary synthesis routes, including physical, chemical, and hybrid cross-linking strategies. Special emphasis is placed on chemical modifications (e.g., sulfation, carboxylation, etherification, and polymer grafting) that allow precise tuning of the gel’s mechanical strength, swelling kinetics, and stimuli-responsiveness (such as pH, temperature, or enzyme sensitivity). Furthermore, the review highlights essential characterization techniques—spanning structural, morphological, and rheological evaluations—used to relate cross-link density to the water-holding capacity and network homogeneity. By leveraging their highly hydrated and porous 3D architectures, these modified cellulosic networks demonstrate exceptional efficiency in drug loading, controlled release, and targeted localized therapy. Finally, we discuss current challenges, including industrial scalability and mechanical stability, and provide future perspectives on integrating nanoparticles and bioactive moieties to develop “smart” drug-eluting matrices and wound care dressings. Ultimately, this review underscores the immense potential of cellulose-based gels in advancing both clinical outcomes and circular economy goals. Full article
(This article belongs to the Special Issue Biobased Gels for Drugs and Cells (2nd Edition))
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16 pages, 9624 KB  
Article
Research on Adhesion Performance of Silicone Gel for Power Module Packaging Regulated by Crosslink Structure and Interfacial Connection
by Xiangze An, Dongxin He, Xiaobin Zheng, Tinghui Li, Cong Zhang and Hongshun Liu
Gels 2026, 12(7), 647; https://doi.org/10.3390/gels12070647 - 19 Jul 2026
Viewed by 323
Abstract
Silicone gel for high-voltage power module packaging is prone to interfacial failure due to poor intrinsic adhesion, which seriously threatens the reliability of devices. This study explores ways to improve the adhesion performance of silicone gel from the two aspects of crosslink network [...] Read more.
Silicone gel for high-voltage power module packaging is prone to interfacial failure due to poor intrinsic adhesion, which seriously threatens the reliability of devices. This study explores ways to improve the adhesion performance of silicone gel from the two aspects of crosslink network structure and interfacial connection. The crosslink structure is regulated by adjusting the ratio of side-hydrogen-containing silicone oil to terminal-hydrogen-containing silicone oil, and interface adhesion is improved by adding three different contents of silane coupling agents (KH560, KH570, A171). The adhesion strength is evaluated by lap shear experiments. The results show that when the ratio of side-hydrogen to terminal-hydrogen is 16:24, the adhesion strength reaches a peak value of 0.0921 MPa. Among the coupling agents, KH560 shows the most significant enhancement, with the adhesion strength reaching 0.1356 MPa at 4% addition and a 47% improvement over the baseline, KH570 is only effective at low addition levels, and A171 shows the weakest effect due to vinyl interference in the crosslink network. Breakdown tests confirm that all three modification schemes do not seriously damage insulation performance. This study provides a feasible strategy and basis for the adhesion reliability design of silicone gel for power module packaging. Full article
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15 pages, 5198 KB  
Article
Synthesis, Characterization, and Genotoxic and Cytotoxic In Vitro Evaluation of Ceramic Nanoparticles of Sc Oxide Powders and Aerogels Doped with Europium Ions
by Israel D. Cabrera Rios, Felipe de J. Carrillo Romo, Antonieta García Murillo, Isela Álvarez González and Eduardo Madrigal Bujaidar
Gels 2026, 12(7), 646; https://doi.org/10.3390/gels12070646 - 19 Jul 2026
Viewed by 311
Abstract
This article reports on the synthesis and characterization of the properties of ceramic powders and aerogels of rare earths using the Sc2O3:Eu2O3 system synthesized through the sol–gel method, as well as on the toxicological effects of [...] Read more.
This article reports on the synthesis and characterization of the properties of ceramic powders and aerogels of rare earths using the Sc2O3:Eu2O3 system synthesized through the sol–gel method, as well as on the toxicological effects of the cytokinesis-block micronucleus cytome assay (CBMC). A sol–gel variant using epoxide-assisted gelling and supercritical CO2 drying was employed to produce the aerogels. In vitro CBMCs were employed to assess the genotoxic and cytotoxic effects of the materials’ dosages and inherent properties. The morphology of the powders and aerogels consisted of agglomerates of irregularly shaped particles. At the same time, structural analysis revealed crystal sizes of 16 and 10 nm, respectively, for the ceramic powders and aerogels, in which microplastic deformations were observed. The cubic crystalline structure of the Sc2O3:Eu2O3 system remained unchanged. However, applying CBMC and observing the genotoxic and cytotoxic effects of the nanoparticles revealed that the main genotoxic xenobiotic agent was the aerogel. The primary mode of cellular death was necrosis, suggesting that reactive oxygen species might have been involved in the genotoxic and cytotoxic damage. Full article
(This article belongs to the Special Issue Synthesis and Emerging Applications of Novel Aerogel Materials)
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16 pages, 12957 KB  
Article
Cobalt Oxide-Containing Glaze/CaAlg Hydrogel Membrane for Degradation of Orange G via Peroxydisulfate Activation
by Bin Zhang, Minglin Wang, Yawen Liu, Jiabao Cui and Kongyin Zhao
Gels 2026, 12(7), 645; https://doi.org/10.3390/gels12070645 - 19 Jul 2026
Viewed by 278
Abstract
The sustained expansion of printing and dyeing operations has led to the discharge of large volumes of organic wastewater containing dyes. The resulting environmental pollution demands urgent solutions, making the development of efficient and eco-friendly methods for the elimination of dyeing wastewater critically [...] Read more.
The sustained expansion of printing and dyeing operations has led to the discharge of large volumes of organic wastewater containing dyes. The resulting environmental pollution demands urgent solutions, making the development of efficient and eco-friendly methods for the elimination of dyeing wastewater critically important. The combination of alginate hydrogel membranes with advanced oxidation processes (AOPs) for water purification represents an emerging approach in the current field of water treatment. In this study, a calcium alginate membrane was loaded with a glaze containing highly active cobalt oxide to fabricate a glaze-calcium alginate (Glaze-CaAlg) composite membrane. The membrane achieved stable degradation of Orange G dye under optimal conditions, and a series of tests were conducted under varying conditions using pollutant concentrations close to those found in real water bodies. Under optimal conditions (glaze loading = 2.5 mL, PMS = 0.3 mmol/L, cross-flow filtration mode), the membrane achieved a 93.7% degradation efficiency of Orange G (10 ppm) within 45 min, with hydroxyl radicals (·OH, ~79%) identified as the predominant reactive species. The Glaze-CaAlg membrane also exhibited excellent reusability, maintaining a degradation efficiency of over 80% for Orange G across five consecutive cycles. Furthermore, sodium citrate was employed to react with the Glaze-CaAlg membrane, enabling the recovery and secondary application of the glaze. Membranes re-fabricated from the recovered glaze showed mechanical strength and catalytic efficiency comparable to those of the pristine membrane. The Glaze-CaAlg membrane possesses high catalytic activity and good stability. This work offers a sustainable, cost-effective, and recyclable catalytic membrane that converts a traditional ceramic material into an advanced functional material for wastewater remediation, with great potential for practical application in the treatment of refractory organic pollutants. Full article
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23 pages, 14267 KB  
Article
Polydopamine-Modified Boron Nitride Reinforced Silicone Gel Composites with Enhanced Thermal Conductivity and Electrical Insulation Performance
by Mengjia Feng, Chaoyue Zhao, Wenbo Li, Xinfeng Lv, Zichen Cui, Jianzeng Guo and Mai Hao
Gels 2026, 12(7), 644; https://doi.org/10.3390/gels12070644 - 19 Jul 2026
Viewed by 361
Abstract
Silicone gel (SG) is widely used as a soft encapsulation material for high-voltage power devices because of its excellent flexibility, thermal stability, and electrical insulation. However, its intrinsically low thermal conductivity and susceptibility to partial discharge (PD) at triple-junction interfaces restrict long-term operational [...] Read more.
Silicone gel (SG) is widely used as a soft encapsulation material for high-voltage power devices because of its excellent flexibility, thermal stability, and electrical insulation. However, its intrinsically low thermal conductivity and susceptibility to partial discharge (PD) at triple-junction interfaces restrict long-term operational reliability. In this study, polydopamine-modified hexagonal boron nitride (P-BN) was introduced into silicone gel to construct thermally conductive and electrically insulating composites. The SG/P-BN composites exhibited reduced filler agglomeration and a more continuous filler–matrix morphology than the corresponding SG/BN composites, while the model-extrapolated trap analysis suggested composition-dependent changes in the higher energy charge trapping states of the P-BN-containing composites. As a result, the SG/P-BN composites exhibited enhanced thermal stability, reduced coefficient of thermal expansion, and improved heat-transfer capability, with thermal conductivity increasing from 0.183 W/m·K for pristine SG to 0.25 W/m·K. The composite containing 2 wt% P-BN showed the best insulation performance, with breakdown strength increasing from 24.05 to 28.45 kV/mm at 25 °C and from 19.59 to 24.71 kV/mm at 150 °C. Under a simplified triple-junction laboratory configuration, the PD inception voltage increased from approximately 3.1 kV for pristine SG to 4.1 kV for SG/P-BN2, accompanied by fewer high-amplitude discharges. This work demonstrates improved material-level thermal conductivity and electrical insulation performance of P-BN-containing silicone gel composites under the investigated laboratory conditions. Full article
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33 pages, 17584 KB  
Review
A Bibliometric and Critical Review of Cellulose-Based Aerogels for Wastewater Treatment
by Fengyun Sun, Mingqiao Wang, Shizuo A. Niu, Xiaodong Zhu, Kefa Ren, Yingge Zhang, Yaru Yang and Dong Liu
Gels 2026, 12(7), 643; https://doi.org/10.3390/gels12070643 - 18 Jul 2026
Viewed by 436
Abstract
The treatment of refractory wastewater pollutants requires advanced materials capable of synergistic enrichment and destruction. Cellulose-based aerogels, combining biomass sustainability with a porous structure, are a promising platform, yet a quantitative synthesis of this field’s evolution is lacking. This study presents the first [...] Read more.
The treatment of refractory wastewater pollutants requires advanced materials capable of synergistic enrichment and destruction. Cellulose-based aerogels, combining biomass sustainability with a porous structure, are a promising platform, yet a quantitative synthesis of this field’s evolution is lacking. This study presents the first bibliometric and visual analysis of 463 publications on cellulose-based aerogels for wastewater treatment. The field shows S-shaped growth, evolving from a Nascent phase to Exponential Growth and now entering Maturation. Social network analysis reveals a China-centered but increasingly international collaboration pattern, while institutional productivity remains fragmented into multiple small research teams. The foundation rests on two synergistic pillars: adsorptive sequestration and catalytic degradation, with research evolving from their parallel development to active fusion. Current frontiers focus on sustainable system engineering, emphasizing process integration, material regeneration, and advanced precursors like cellulose nanofiber. This analysis maps the field’s maturation from material exploration toward integrated catalytic system design, providing a foundational reference and clear directives for future research to address integration challenges. In addition to bibliometric mapping, this review critically discusses treatment functions (adsorption, catalytic oxidation, and integrated pathways) and deployment barriers (regeneration, recyclability, and scale-up feasibility), thereby linking knowledge evolution to practical wastewater-treatment translation. While China contributes the largest publication share in the present dataset, the field is supported by increasing participation from multiple countries and regions. Full article
(This article belongs to the Section Gel Analysis and Characterization)
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25 pages, 5639 KB  
Review
Empowering Extracellular Vesicle Wound Therapy via Local Drug Delivery Systems: Mechanistic Insights and Advanced Stimuli-Responsive Strategies
by Ziqiao Zhong, Ziyi Feng, Yawen Huang, Zhenhao Li, Libing Lu, Lu Gan, Xincheng Lin, Xiaolu Xiao, Yichun Zheng, Xin Pan, Chuanbin Wu, Ying Huang and Wenhao Wang
Gels 2026, 12(7), 642; https://doi.org/10.3390/gels12070642 - 18 Jul 2026
Viewed by 406
Abstract
Extracellular vesicles have emerged as promising cell-free therapeutic agents for wound healing due to their remarkable ability to modulate inflammatory responses, promote angiogenesis, and enhance tissue regeneration. These biological nanocarriers deliver bioactive cargo, including regulatory miRNAs, proteins, and lipids, to recipient cells, thereby [...] Read more.
Extracellular vesicles have emerged as promising cell-free therapeutic agents for wound healing due to their remarkable ability to modulate inflammatory responses, promote angiogenesis, and enhance tissue regeneration. These biological nanocarriers deliver bioactive cargo, including regulatory miRNAs, proteins, and lipids, to recipient cells, thereby modulating key signaling pathways governing tissue repair. However, the clinical translation of extracellular vesicle (EV)-based therapies is substantially limited by challenges in delivery efficiency. Local drug delivery systems (LDDSs) offer several key advantages, including reduced clearance by the reticuloendothelial system, enhanced biodistribution to wound sites, prolonged local residence time, and precise spatial targeting of therapeutic effects. This review systematically summarizes recent advances in EV-based therapies for wound repair, with a particular focus on in situ forming and implantable LDDSs, such as stimuli-responsive hydrogels. We comprehensively discuss the molecular and cellular mechanisms through which EVs facilitate healing across all phases of wound repair. Furthermore, we critically evaluate the evolution of these delivery platforms, transitioning from conventional passive-release systems to advanced stimuli-responsive hydrogels and microneedle systems, assessing their design rationale and integration with EV biology. We also address key translational challenges and opportunities: scalable manufacturing, standardized quality control, and regulatory pathways, offering a forward-looking view on clinical implementation of EV-LDDS hybrids in precision regenerative therapy. Full article
(This article belongs to the Special Issue Novel Hydrogels for Drug Delivery and Regenerative Medicine)
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28 pages, 7385 KB  
Article
Investigating the Performance of Asphalt Modified with Rubber Powder and Surface Organic Layered Double Hydroxides
by Chenze Fang, Xu Guo, Yuanzhao Chen, Zhenxia Li, Tengteng Guo, Hui Li, Jingyu Yang, Haijun Chen, Qi Chen, Chaohui Wang, Qian Chen, Xiaoyan Han and Yi Lu
Gels 2026, 12(7), 641; https://doi.org/10.3390/gels12070641 - 17 Jul 2026
Viewed by 339
Abstract
In order to promote the sustainable development of road engineering, this study used waste tire rubber powder (RP) and surface organic layered double hydroxide (SOM-LDHs) to modify 70# matrix asphalt. The Box–Behnken design response surface method with three factors (rubber powder content, surface [...] Read more.
In order to promote the sustainable development of road engineering, this study used waste tire rubber powder (RP) and surface organic layered double hydroxide (SOM-LDHs) to modify 70# matrix asphalt. The Box–Behnken design response surface method with three factors (rubber powder content, surface organic layered double hydroxide content, shear temperature) and three responses (penetration, ductility, softening point) was used to optimize the preparation parameters. The optimum formula was determined to be 21.7% rubber powder content, 4.8% surface organic layered double hydroxide content, and 160 °C shear temperature. The effect of the modifier on the surface morphology was analyzed using a rotating film oven test and ultraviolet aging test. The high and low temperature rheological properties of asphalt were evaluated by dynamic shear rheometer (DSR), bending beam rheometer (BBR), and the multi-stress creep recovery test (MSCR). The microstructure was observed by scanning electron microscopy (SEM) and atomic force microscopy (AFM). The aging mechanism was investigated by Fourier transform infrared spectroscopy (FTIR) and gel permeation chromatography (GPC). The results show that after aging, the complex shear modulus of rubber powder/surface organic layered double hydroxide composite modified asphalt is the highest, which is 27.35% higher than that of matrix asphalt. The rutting factor reaches 79.86 kPa at 46 °C, the phase angle decreases by 11.83% after UV aging, and the high temperature plastic deformation resistance is the best. In the low temperature range of −18 °C to −24 °C, the creep stiffness of the composite modified asphalt is about 30% lower than that of the matrix asphalt, while the m value is increased by about 15%, and the low temperature stress relaxation performance is significantly improved. The strain recovery rate of composite modified asphalt under 3.2 kPa stress reaches 78.5%, and the unrecoverable creep compliance is as low as 0.18 kPa−1, which is better than that of matrix asphalt and single rubber powder modified asphalt. Full article
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34 pages, 1786 KB  
Review
Multifunctional Hydrogels for Diabetic Wound Healing: Design Strategies and Microenvironmental Remodeling Mechanisms
by Yu Zeng, Yijun Huang, Xinying Zhong, Li Li, Dao Chen and Lin Li
Gels 2026, 12(7), 640; https://doi.org/10.3390/gels12070640 - 17 Jul 2026
Viewed by 558
Abstract
Diabetic wounds remain a major clinical challenge owing to persistent dysregulation of the wound microenvironment, which substantially limits the effectiveness of conventional therapies. In recent years, multifunctional hydrogels have emerged as promising platforms for diabetic wound management, attributed to their excellent biocompatibility, tunable [...] Read more.
Diabetic wounds remain a major clinical challenge owing to persistent dysregulation of the wound microenvironment, which substantially limits the effectiveness of conventional therapies. In recent years, multifunctional hydrogels have emerged as promising platforms for diabetic wound management, attributed to their excellent biocompatibility, tunable physicochemical properties, and unique capacity to actively remodel pathological microenvironments through integrated therapeutic functions. This comprehensive narrative review provides an in-depth synthesis of the pathogenesis and current therapeutic strategies for diabetic wounds, with a particular focus on recent advances in multifunctional hydrogels, as well as their classification, design principles, mechanisms of action, and translational potential. Furthermore, emerging directions are discussed as promising approaches for next-generation therapies, including intelligent closed-loop systems, interdisciplinary technological convergence, and the integration of bioactive components derived from traditional Chinese medicine. Collectively, these advances are poised to facilitate the transition from passive wound coverage to active microenvironment remodeling, paving the way for precision and personalized diabetic wound care. Full article
(This article belongs to the Section Gel Analysis and Characterization)
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39 pages, 38598 KB  
Review
Anti-Swelling Hydrogel Wearable Sensors: Structural Engineering, Internal Water Environment Regulation, and Motion Monitoring in Complex Environments
by Qinglei Li, Ping Shen, Zhihao Liu, Haonan He, Weiquan Shi, Hao Hong, Jaeyoung Park, Kaixin Xu and Jie Wu
Gels 2026, 12(7), 639; https://doi.org/10.3390/gels12070639 - 17 Jul 2026
Viewed by 431
Abstract
As wearable sensors advance toward long-term motion monitoring and operation in humid environments, performance priorities are shifting from sensitivity to sustained reliability. Hydrogels are attractive sensing materials due to their tissue-like compliance, biocompatibility, and tunable conductivity; however, their hydrated networks readily absorb water [...] Read more.
As wearable sensors advance toward long-term motion monitoring and operation in humid environments, performance priorities are shifting from sensitivity to sustained reliability. Hydrogels are attractive sensing materials due to their tissue-like compliance, biocompatibility, and tunable conductivity; however, their hydrated networks readily absorb water under perspiration, high humidity, and underwater conditions, leading to structural relaxation, interfacial instability, conductive pathway disruption, and signal drift. Thus, anti-swelling design should move beyond reducing swelling ratios toward coordinated regulation of water transport, internal water environment, interfacial integrity, and signal stability. This review summarizes recent advances in anti-swelling hydrogel-based wearable sensors, focusing on structural engineering strategies, including network confinement, surface hydrophobicity, core–shell architectures, and gradient structures, as well as material regulation mechanisms, including ionic/coordination crosslinking, nanoconfinement, zwitterionic hydration, and solvation-mediated anti-water exchange, highlighting their synergistic roles in long-term anti-swelling performance and environmental adaptability. Representative applications in perspiration monitoring, underwater motion sensing, rehabilitation, and intelligent interaction demonstrate the importance of anti-swelling regulation for reliable sensing in wet environments. Finally, the remaining challenges are summarized, together with future perspectives on the synergistic design of structures, materials, and interfaces, standardized evaluation systems for realistic motion environments, and scalable manufacturing. Anti-swelling hydrogel sensors are expected to evolve from low-swelling materials into environmentally adaptive sensing platforms for aqueous environments, enabling advances in underwater sports monitoring, digital health, and underwater human–machine interaction. Full article
(This article belongs to the Special Issue Recent Progress of Hydrogel Sensors and Biosensors (2nd Edition))
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22 pages, 10208 KB  
Article
SVF Combined with HGF-Functionalized Self-Assembling Peptide Hydrogel Promotes Spinal Cord Injury Repair in Rats
by Feng Yang, Tiantian Li, Yu Wang, Yanling Chen, Xuhuai Chen, Linshu Ding, Yuanyi Liu, Jialin Li, Guanbo Huang, Haibo Zhou, Qiuju Yuan and Wutian Wu
Gels 2026, 12(7), 638; https://doi.org/10.3390/gels12070638 - 16 Jul 2026
Viewed by 417
Abstract
Spinal cord injury (SCI) is a devastating neurological disorder. The development of effective therapies to ameliorate the consequences of SCI represents a major challenge and a central priority of international biomedical research. The stromal vascular fraction (SVF) derived from adipose tissue possesses considerable [...] Read more.
Spinal cord injury (SCI) is a devastating neurological disorder. The development of effective therapies to ameliorate the consequences of SCI represents a major challenge and a central priority of international biomedical research. The stromal vascular fraction (SVF) derived from adipose tissue possesses considerable functional potential. SVF is a heterogeneous mixture of cells that act synergistically. However, after local transplantation, SVF is rapidly cleared via the bloodstream, and its poor survival severely compromises therapeutic efficacy. To overcome this limitation, we employed a self-assembling peptide nanohydrogel HGF-RADA16-IKVAV (where HGF denotes the tripeptide histidine–glycine–phenylalanine) as a scaffold to enhance SVF retention and efficacy in a rat model of SCI. Implantation of SVF and HGF into the injured spinal cord demonstrated that this combined therapy significantly modulated the inflammatory response, increased neuronal survival, and promoted a denser network of axon tracts. Consequently, the SVF-encapsulated HGF hydrogel resulted in superior restoration of limb movement and reduced neuropathic pain. Proteomic analysis confirmed that the combined treatment shifted the injury-induced molecular landscape, particularly in immune and inflammatory pathways. Collectively, these findings demonstrate that this combinatorial strategy represents an effective therapeutic paradigm for SCI. Full article
(This article belongs to the Section Gel Analysis and Characterization)
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31 pages, 8222 KB  
Article
Preparation of Multifunctional Hydrogel Loaded with Isochlorogenic Acid A/Fe3+ Co-Assembled Nanoparticles and Its Application in Skin Wound Repair
by Hui Li, Danli Peng, Zhijia Wang, Yuping Zhang, Xingyu Yang, Yongmei Jiang, Xin Zhang, Lei Zhu, Yanlei Guo, Yongai Xiong and Gang Wang
Gels 2026, 12(7), 637; https://doi.org/10.3390/gels12070637 - 16 Jul 2026
Viewed by 362
Abstract
The skin serves as the largest protective barrier organ of the human body and is easily impaired by trauma, infection and chronic diseases. Efficient wound dressings are indispensable for repairing infected wounds. Isochlorogenic acid A (IAA), the core active ingredient of Shanyinhua, has [...] Read more.
The skin serves as the largest protective barrier organ of the human body and is easily impaired by trauma, infection and chronic diseases. Efficient wound dressings are indispensable for repairing infected wounds. Isochlorogenic acid A (IAA), the core active ingredient of Shanyinhua, has superior anti-inflammatory and antibacterial effects. However, low water solubility and weak structural stability restrict its direct application in wound treatment. In this work, IAA@Fe(III) nanoparticles (IAA@Fe(III) NPs) were synthesized through self-assembly and loaded into cross-linked amylopectin (Amy)/carboxymethyl chitosan (CMCS) (AC hydrogel) to construct Amy/CMCS@NPs composite dressings. Characterizations demonstrated that nanoparticles displayed a uniform spherical shape with a size of 114.20 ± 2.29 nm and stable coordination. The hydrogel featured a dense porous structure and outstanding mechanical performance, self-healing ability, adhesion, and swelling properties. In vitro tests proved that 50 mg/mL composite hydrogel exerted nearly 100% bacteriostatic activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus), with good biocompatibility, and enhanced cell migration capacity. In vivo assays indicated an 86.5% wound healing rate at day 7. This dressing could downregulate Tumor Necrosis Factor-α (TNF-α) and Interleukin-1β (IL-1β), upregulate Cluster of Differentiation 31 (CD31) and Vascular Endothelial Growth Factor (VEGF), and accelerate wound repair. This study provides a theoretical and experimental basis for the exploitation of IAA-based wound dressings and high-value utilization of Shanyinhua resources. Full article
(This article belongs to the Section Gel Applications)
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23 pages, 19159 KB  
Article
Structure-Property Relationships Governing Encapsulation and Release of Antibiotics from Calcium–Alginate Hydrogels
by İbrahim Hebip, İrem Toprakçı, Rabia Nur Bozkurt, Ebru Kurtulbaş and Selin Şahin
Gels 2026, 12(7), 636; https://doi.org/10.3390/gels12070636 - 16 Jul 2026
Viewed by 441
Abstract
Understanding mass transport of structurally different drugs within ionically crosslinked hydrogel networks remains an important challenge in polymer-based delivery systems. In this study, hydrophilic amoxicillin (AMOX) and amphiphilic doxycycline (DOX) were encapsulated into calcium–alginate beads, respectively. A three-factor and three-level Box–Behnken design was [...] Read more.
Understanding mass transport of structurally different drugs within ionically crosslinked hydrogel networks remains an important challenge in polymer-based delivery systems. In this study, hydrophilic amoxicillin (AMOX) and amphiphilic doxycycline (DOX) were encapsulated into calcium–alginate beads, respectively. A three-factor and three-level Box–Behnken design was utilized to examine the influences of alginate concentration (2–5%, w/v), CaCl2 concentration (1–3%, w/v), and gelation time (15–45 min) on encapsulation efficiency (EE). EE exhibited considerable variability for both AMOX (10–86%) and DOX (10–63%). Optimal EE values were achieved at almost 3.5% alginate and 3% CaCl2. The optimized gelation times differed between AMOX (45 min) and DOX (15 min), which is likely associated with differences in their physicochemical properties, although additional intermediate gelation times could further refine the optimal conditions. ANOVA identified CaCl2 concentration and the quadratic effect of alginate as the most influential parameters. Furthermore, both models demonstrated robust predictive capability (R2 > 0.98). In vitro release experiments demonstrated minimal drug diffusion in simulated gastric fluid (SGF) and significantly accelerated release in simulated intestinal fluid (SIF). These findings indicate a pH-responsive release behavior under simulated gastrointestinal conditions. The release profile was best represented by Higuchi and Korsmeyer–Peppas kinetic models. SEM and optical microscopy revealed uniform spherical beads with drug-dependent microstructural differences: hydrophilic AMOX produced smoother, wrinkled surfaces, whereas amphiphilic DOX induced localized cracking and heterogeneous microdomains. Furthermore, DLS and zeta potential measurements of the released fractions indicated nanoscale particle populations (≈190–225 nm) with moderate negative surface charge (≈−21 mV), suggesting stable colloidal dispersion during intestinal-phase release. Full article
(This article belongs to the Special Issue Hydrogel for Sustained Delivery of Therapeutic Agents (3rd Edition))
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23 pages, 19424 KB  
Article
Drug Delivery and Visual Monitoring of Nd(ATA)-GelMA Composite Hydrogels
by Tongyu Qiu, Fengyuan Bian, Tong Meng, Wei Zhou, Weijie Zhang, Ming Ma, Yihu Wang and Bing Zhang
Gels 2026, 12(7), 635; https://doi.org/10.3390/gels12070635 - 16 Jul 2026
Viewed by 302
Abstract
In this study, taking NdCl3 and 2-amino-1,4-benzenedicarboxylic acid (H2ATA) as raw materials, a novel lanthanide metal–organic framework, Nd(ATA), was synthesized by the coprecipitation method. After loading antibiotic levofloxacin (LEV), Nd(ATA) was combined with GelMA hydrogel to prepare a drug-loaded composite [...] Read more.
In this study, taking NdCl3 and 2-amino-1,4-benzenedicarboxylic acid (H2ATA) as raw materials, a novel lanthanide metal–organic framework, Nd(ATA), was synthesized by the coprecipitation method. After loading antibiotic levofloxacin (LEV), Nd(ATA) was combined with GelMA hydrogel to prepare a drug-loaded composite hydrogel, LEV@Nd(ATA)-Gel, which can emit near-infrared fluorescence under excitation at 808 nm and possesses improved mechanical properties compared to pure GelMA hydrogel. LEV@Nd(ATA)-Gel exhibited high bactericidal activity and low cytotoxicity, with cell viability increased by 35% compared to the control group. The release rate of the loaded LEV was found increasing with the pH decreasing from 7 to 3, and demonstrated a potential responsiveness to wound microenvironment. Furthermore, drug delivery studies revealed a significant correlation with the fluorescence intensity of the composite hydrogel and the drug release behavior, and the extent of drug release was quantitatively captured by an in vitro imaging technology. This study successfully integrated the drug release with fluorescent signal of carrier, providing a highly sensitive and visualizable strategy for the development of internal wound adhesive. Full article
(This article belongs to the Special Issue Design and Development of Gelatin-Based Materials (2nd Edition))
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16 pages, 3655 KB  
Article
A Temperature-Ultraviolet-Responsive Fluorescent Anti-Counterfeiting Hydrogel
by Tian Yu, Zhong-Xiang Tang, Meng Jin, Hui Ren, Bin Wu, Yu-Zhuo Fan, Ze-Hui Bai, Fang-Chang Tsai, Xue-Qing Zhan and Ning Ma
Gels 2026, 12(7), 634; https://doi.org/10.3390/gels12070634 - 16 Jul 2026
Viewed by 329
Abstract
Information security and anti-counterfeiting are crucial across various industries. To address the limitations of traditional anti-counterfeiting materials, including low responsiveness, easy replication, and poor environmental stability, a fluorescein (Flu) loaded zeolitic imidazolate framework (ZIF-8) photothermal-responsive anti-counterfeiting hydrogel was designed. Flu was first confined [...] Read more.
Information security and anti-counterfeiting are crucial across various industries. To address the limitations of traditional anti-counterfeiting materials, including low responsiveness, easy replication, and poor environmental stability, a fluorescein (Flu) loaded zeolitic imidazolate framework (ZIF-8) photothermal-responsive anti-counterfeiting hydrogel was designed. Flu was first confined within ZIF-8 via a one-pot method and then embedded into a polyacrylamide/lauryl methacrylate (PAM/LMA) network. This hydrogel emits intense green luminescence under 365 nm UV illumination. Its fluorescence can be quenched by Fe3+ and recovered upon exposure to PO43−, which endows the material with rewritable data storage capacity. Sodium dodecyl sulfate (SDS) and sodium chloride (NaCl) in the hydrogel provide a temperature-dependent reversible transparency transition, allowing multi-level information encryption through the synergistic action of temperature, ions, and UV light. In addition, the hydrogel also features low toxicity, degradability, and an environmentally friendly solvent-free synthesis. This work demonstrates a multi-stimuli responsive strategy that overcomes the limitation of traditional single-responsive anti-counterfeiting materials, offering a promising approach for the design of rewritable and eco-friendly intelligent anti-counterfeiting systems and serving as a reference for the development of multifunctional responsive materials. Full article
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24 pages, 59039 KB  
Article
Fabrication of Chondroitin Sulfate–Copper/Zinc Complexes and Antibacterial Activity Involving Hydrogel Application in Infected Wound Healing
by Qingshan Shen, Jiarui Wu, Jiawen Li, Yujie Dong, Yang Liu, Lei Zhao, Huan Zhan and Yanli Ma
Gels 2026, 12(7), 633; https://doi.org/10.3390/gels12070633 - 15 Jul 2026
Viewed by 346
Abstract
The escalating prevalence of bacterial infections has intensified the search for innovative antimicrobial strategies, particularly for infected wound management. Chondroitin sulfate (CS), a naturally occurring glycosaminoglycan with established biocompatibility, presents an attractive scaffold for developing metal ion-functionalized biomaterials. This study reports the fabrication [...] Read more.
The escalating prevalence of bacterial infections has intensified the search for innovative antimicrobial strategies, particularly for infected wound management. Chondroitin sulfate (CS), a naturally occurring glycosaminoglycan with established biocompatibility, presents an attractive scaffold for developing metal ion-functionalized biomaterials. This study reports the fabrication of chondroitin sulfate–copper complex (CSCu) and chondroitin sulfate–zinc complex (CSZn) through an ion exchange method, wherein Cu2+ and Zn2+ ions bind to the groups of carboxylate, sulfate, or N-acetyl from the CS backbone. The resulting complexes exhibited copper or zinc loading capacities of about 6.6% and demonstrated potent antibacterial activity against E. coli and S. aureus. The integration of CSCu or CSZn with sodium alginate yielded a hydrogel system with a higher apparent viscosity, possessing injectability and spreadability on the skin surface and a porous three-dimensional internal structure conducive to wound healing applications. In a murine model of S. aureus-infected full-thickness wounds, topical application of CSCu and CSZn hydrogels substantially accelerated wound closure, achieving 97.46% and 98.11% healing, respectively, by day 10. Additionally, treatment with CSCu or CSZn hydrogels significantly attenuated systemic inflammatory responses, as reflected in lowered serum TNF-α, IL-1β, and IL-6 alongside increased IL-10. Histological evaluation confirmed enhanced re-epithelialization and stratum spinosum formation in treated wounds. These findings establish CSCu and CSZn as a promising bioactive agent for addressing bacterial wound infections through a dual mechanism of direct antibacterial action and immunomodulatory effects, offering a valuable alternative to conventional antibiotic therapies. Full article
(This article belongs to the Section Gel Applications)
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32 pages, 27015 KB  
Review
Ambient Pressure Drying for Fabrication of Cellulose-Based Lightweight Porous Materials: A Review
by Zhiqiang Xu and Li Wang
Gels 2026, 12(7), 632; https://doi.org/10.3390/gels12070632 - 15 Jul 2026
Viewed by 404
Abstract
The depletion of fossil resources and environmental pollution issues have accelerated the development of biomass-based lightweight porous materials. Cellulose-based lightweight porous materials (CLPMs) have emerged as ideal alternatives to petroleum-based porous materials owing to their advantages of renewability and biodegradability. Ambient pressure drying [...] Read more.
The depletion of fossil resources and environmental pollution issues have accelerated the development of biomass-based lightweight porous materials. Cellulose-based lightweight porous materials (CLPMs) have emerged as ideal alternatives to petroleum-based porous materials owing to their advantages of renewability and biodegradability. Ambient pressure drying has become an ideal solution for the large-scale production of CLPMs; owing to its low cost, short processing time, and ease of operation. However, challenges such as strong capillary forces, reorganization of intermolecular hydrogen bonds, and insufficient framework strength can lead to the collapse of the porous structure during the drying process. This review systematically summarizes the research progress of ambient pressure drying techniques for CLPMs, providing an in-depth analysis of the intrinsic mechanisms underlying structural collapse in terms of capillary pressure, hydrogen bond reorganization, and structural strength. Based on this analysis, five major control strategies for ambient pressure drying, such as solvent substitution and surface hydrophobic modification, are outlined. Furthermore, this review comprehensively discusses the practical application prospects of such materials in adsorption, thermal insulation, and other fields. This review aims to provide theoretical references for the development and industrialization of CLPMs. Full article
(This article belongs to the Special Issue Cellulose Gels: Preparation, Properties and Applications)
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22 pages, 3132 KB  
Review
Pullulan-Based Gels with Food-Related Orientation: From Microbial Production to Synergistic Assemblies
by Maria Syrigou and Erminta Tsouko
Gels 2026, 12(7), 631; https://doi.org/10.3390/gels12070631 - 15 Jul 2026
Viewed by 447
Abstract
Pullulan is a microbial exopolysaccharide produced primarily by Aureobasidium spp. It has attracted considerable attention due to its biodegradability, biocompatibility, and versatility in food-related applications. While its basic chemical structure has long been established, recent advances have significantly improved the understanding of the [...] Read more.
Pullulan is a microbial exopolysaccharide produced primarily by Aureobasidium spp. It has attracted considerable attention due to its biodegradability, biocompatibility, and versatility in food-related applications. While its basic chemical structure has long been established, recent advances have significantly improved the understanding of the genetic, enzymatic, and regulatory mechanisms governing its biosynthesis. This review discusses current knowledge on pullulan production, focusing on biosynthetic pathways, regulatory networks, and the influence of fermentation conditions on polymer yield and quality. Particular emphasis is placed on the utilization of agro-industrial residues as renewable feedstocks within a circular bioeconomy framework, as well as on downstream recovery and purification strategies. Furthermore, the physicochemical properties of pullulan and its ability to form synergistic assemblies with other biopolymers are evaluated in relation to hydrogels, edible films, active packaging, and bioactive delivery systems. By integrating microbial biotechnology, bioprocess engineering, and material science, this review provides a comprehensive overview of pullulan-based systems for food-related applications. Full article
(This article belongs to the Special Issue Recent Advances in Food Gels—3rd Edition)
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32 pages, 9825 KB  
Article
An Ultrasound-Responsive Bio-Adhesive Piezoelectric Hydrogel for Osteoarthritis Cartilage
by Yuan Li, Ziyu Chen, Shiyu Zhu, Yan Wei, Zhen Geng, Jianping Huang and Mengmeng Li
Gels 2026, 12(7), 630; https://doi.org/10.3390/gels12070630 - 15 Jul 2026
Viewed by 362
Abstract
Osteoarthritis (OA) is a degenerative joint disease characterized by progressive loss of articular cartilage and an associated decline in its intrinsic mechanoelectrical signaling. Current osteoarthritis treatments relieve symptoms but fail to prevent cartilage degeneration or restore its native biophysical microenvironment. Here, we present [...] Read more.
Osteoarthritis (OA) is a degenerative joint disease characterized by progressive loss of articular cartilage and an associated decline in its intrinsic mechanoelectrical signaling. Current osteoarthritis treatments relieve symptoms but fail to prevent cartilage degeneration or restore its native biophysical microenvironment. Here, we present an ultrasound-activated, mussel-inspired bio-adhesive hydrogel that addresses these challenges by recreating the cartilage’s piezoelectric cues in situ while achieving stable intra-articular retention under synovial conditions. The hydrogel, denoted SFHD-BT@PDA, consists of a silk fibroin (SF) matrix integrated with dopamine-functionalized hyaluronic acid (HADA) and embedded barium titanate nanoparticles coated with polydopamine (BT@PDA). This multi-level design imparts strong interfacial adhesion to wet cartilage (via catechol-mediated bonding to collagen) and piezoelectric sensitivity to external ultrasound. Under ultrasound stimulation, SFHD-BT@PDA generates localized electrical microcurrents that recruit endogenous MSCs via electrotaxis and subsequently promote their chondrogenic differentiation. In vitro, ultrasound-triggered electrical cues upregulated chondrogenic markers (SOX9, collagen II, aggrecan) in MSCs and activated TGF-β signaling, demonstrating restoration of the pro-anabolic bioelectric microenvironment. In a murine DMM model, the adhesive hydrogel exhibited prolonged retention on cartilage surfaces and, with ultrasound, induced robust cartilage regeneration and OA reversal. Treated joints showed preserved proteoglycan and Type II collagen content, inhibited osteophyte formation, and protection of subchondral bone microarchitecture. In summary, this mussel-inspired piezoelectric hydrogel provides an electromechanical stimulation platform that effectively couples physical cues with bio-adhesion to regenerate cartilage. Full article
(This article belongs to the Special Issue Hydrogels for Tissue Repair: Innovations and Applications)
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18 pages, 2248 KB  
Article
Structural and Antimicrobial Characterization of Porcine and Fish Gelatin Hydrogels Photochemically Crosslinked with Menadione Sodium Bisulfite
by Vladislav Abramov, Yuriy F. Zuev, Mariya A. Klimovitskaya, Polina V. Skvortsova, Galina J. Yakovleva, William Kurdy and Olga N. Ilinskaya
Gels 2026, 12(7), 629; https://doi.org/10.3390/gels12070629 - 15 Jul 2026
Viewed by 326
Abstract
Gelatin-based hydrogels are promising matrices for wound management, but their direct application is constrained by insufficient structural stability and lack of intrinsic antimicrobial activity. Porcine and fish gelatin hydrogels were photochemically crosslinked with menadione sodium bisulfite (MSB), a water-soluble hemostatic derivative of vitamin [...] Read more.
Gelatin-based hydrogels are promising matrices for wound management, but their direct application is constrained by insufficient structural stability and lack of intrinsic antimicrobial activity. Porcine and fish gelatin hydrogels were photochemically crosslinked with menadione sodium bisulfite (MSB), a water-soluble hemostatic derivative of vitamin K3, and characterized by ATR-FTIR and 1H NMR spectroscopy, together with antimicrobial testing against Staphylococcus aureus, Candida albicans, Escherichia coli, and Salmonella enterica. FTIR analysis showed that MSB crosslinking retards the thermal disruption of collagen-like triple helices in both gelatins, with the effect being more pronounced in porcine gelatin owing to its higher imino acid content and more developed collagen-like network. NMR measurements confirmed that crosslinking increases the bound-water fraction approximately threefold in porcine and twofold in fish gelatin, while the bulk water mobility stays unchanged. MSB crosslinking enhanced antimicrobial activity against S. aureus and C. albicans by up to 5.6-fold relative to non-crosslinked controls and additionally conferred activity against E. coli, while S. enterica remained resistant in all variants. MSB, thus, simultaneously serves as a structural crosslinker and imparts intrinsic antimicrobial activity to the resulting hydrogels, making them a promising basis for multifunctional wound-healing materials. Full article
(This article belongs to the Special Issue Designing Gels for Wound Dressing (2nd Edition))
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35 pages, 3730 KB  
Article
Protocol-Dependent Effects on Colloidal Characterization and Drug Loading/Release Analysis of Thermosensitive PNIPAM-co-COOH Microgels
by José López-Molina, Alba Garrido-Rodríguez, María Tirado-Miranda, Delfi Bastos-González, Miguel A. Fernández-Rodríguez, Carmen Casas-Herce, Adri Escañuela-Copado, Arturo Moncho-Jordá, Irene Adroher-Benítez, J. Manuel López-Romero, Ana B. Jódar-Reyes and José M. Peula-García
Gels 2026, 12(7), 628; https://doi.org/10.3390/gels12070628 - 14 Jul 2026
Viewed by 413
Abstract
This work analyzes protocol-dependent effects on the colloidal characterization and drug loading/release analysis of model thermosensitive PNIPAM-co-COOH microgels and shows how they can be quantified or minimized through targeted methodological refinements. Findings reveal that standard single-beam DLS underestimates the collapsed hydrodynamic radius by [...] Read more.
This work analyzes protocol-dependent effects on the colloidal characterization and drug loading/release analysis of model thermosensitive PNIPAM-co-COOH microgels and shows how they can be quantified or minimized through targeted methodological refinements. Findings reveal that standard single-beam DLS underestimates the collapsed hydrodynamic radius by 18% at 43 °C due to thermal convection. After drift correction, 3D-DLS combined with SLS provides a consistent description of thermally induced collapse, pH-dependent swelling and core–corona structure. Regarding drug delivery, loading efficiency for Doxorubicin and 5-Fluorouracil is maximized near the volume phase transition temperature, where hydrophobic interactions are strongest. For release studies, dialysis is recommended, but free-drug blanks are required to account for membrane-induced delay and ensure accurate early kinetic profiles. By integrating TEM, AFM, SLS, DLS, NTA and LDE, this study establishes a robust framework for the colloidal characterization of thermosensitive microgels. These refinements reduce experimental bias and may be extended to related soft nanocarriers. Full article
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20 pages, 11427 KB  
Article
Synergistic Hydrogels Enabled by Dual-Regulatory Mussel Foot Protein for Advancing Wound Healing
by Jiren Xu, Na Li, Chen Wang, Jeevithan Elango, Wenhui Wu, Peng Fu and Bailei Li
Gels 2026, 12(7), 627; https://doi.org/10.3390/gels12070627 - 14 Jul 2026
Viewed by 358
Abstract
Impaired wound healing is often caused by persistent inflammation, bacterial infection, and insufficient extracellular matrix remodeling. Natural polymer-based hydrogels represent ideal wound dressings but often struggle to balance structural stability and biological activity. Herein, we report a dual-functional network regulation strategy enabled by [...] Read more.
Impaired wound healing is often caused by persistent inflammation, bacterial infection, and insufficient extracellular matrix remodeling. Natural polymer-based hydrogels represent ideal wound dressings but often struggle to balance structural stability and biological activity. Herein, we report a dual-functional network regulation strategy enabled by highly soluble mussel foot protein (HMFP) that acts simultaneously as a structural crosslinking regulator and bioactive effector to fabricate synergistic hydrogels (CS-SH-H) from β-chitosan (CS) and sodium hyaluronate (SH). HMFP homogenizes the porous microstructure, strengthens intermolecular interactions, and significantly improves thermal and structural stability via multivalent non-covalent bonding. In vitro, CS-SH-H shows excellent cytocompatibility, significantly promotes fibroblast proliferation and migration, and exerts potent antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). In a mouse full-thickness skin defect model, the hydrogel dramatically accelerates wound closure, reducing the residual wound area to 25% on day 7, outperforming the control groups. Immunohistochemistry confirms that HMFP suppresses TNF-α-mediated inflammation and enhances Ki-67-positive cell proliferation, leading to accelerated re-epithelialization and collagen deposition. This study establishes HMFP as a promising marine-derived dual-functional network regulator for designing high-performance hydrogel dressings. This strategy is scalable and translatable for treating infected and inflammatory wounds. Full article
(This article belongs to the Section Gel Applications)
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