Hydrogels for Tissue Repair: Innovations and Applications

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 311

Special Issue Editor


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Guest Editor
School of Material Science and Engineering, East China University of Science and Technology, Shanghai 200231, China
Interests: hydrogels; active biomaterials; amino acid polymers; cell adhesion; tissue repair

Special Issue Information

Dear Colleagues,

Hydrogels have emerged as a revolutionary material in modern biomedical research, especially in the realm of tissue repair. The native cell microenvironment is a sophisticated ecosystem that provides essential signals for cell growth, differentiation, and tissue homeostasis. Our efforts in developing hydrogels aim to precisely mimic these conditions. For instance, in bone repair, we design hydrogels with suitable stiffness and bioactive components to encourage osteoblast adhesion and bone formation. In cartilage repair, the hydrogels are engineered to match the viscoelasticity of natural cartilage, facilitating chondrocyte function. For myocardial repair, these hydrogels can serve as delivery vehicles for growth factors and support the regeneration of damaged cardiac tissue.

This Special Issue aims to gather the latest research on hydrogels for tissue repair. We welcome contributions from all over the world, covering aspects such as hydrogel synthesis, characterization, and their applications in different tissue repair scenarios. By sharing our knowledge and findings, we can accelerate the development of hydrogel-based therapies and improve the quality of life for patients suffering from tissue-related diseases.

Dr. Qi Chen
Guest Editor

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Keywords

  • hydrogels
  • tissue repair
  • natural cell microenvironment
  • bone repair
  • cartilage repair
  • myocardial repair

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Published Papers (1 paper)

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Research

16 pages, 5559 KiB  
Article
Sodium Alginate Hydrogel Sponges Embedded with M2 Macrophages: An Adoptive Cell Therapy Strategy for Accelerated Diabetic Wound Healing
by Qingchang Tian, Wenqi Li, Lijiaqi Zhang, Kefen Gan, Yiting Zhang and Shuling Wang
Gels 2025, 11(7), 502; https://doi.org/10.3390/gels11070502 - 27 Jun 2025
Viewed by 220
Abstract
Hydrogels possess advantages for providing a moist wound environment and enabling drug or cell delivery. Wound healing is a complex, multistage process where macrophages play a pivotal role; they influence inflammation resolution, anti-inflammatory cytokine production, angiogenesis, and extracellular matrix remodeling. Combining hydrogel materials [...] Read more.
Hydrogels possess advantages for providing a moist wound environment and enabling drug or cell delivery. Wound healing is a complex, multistage process where macrophages play a pivotal role; they influence inflammation resolution, anti-inflammatory cytokine production, angiogenesis, and extracellular matrix remodeling. Combining hydrogel materials with adoptive M2 macrophages offers a promising adoptive cell therapy approach to accelerate healing. In the present study, sodium alginate, a natural polymer, was harnessed to create hydrogel sponges embedded with M2 macrophages for application to chronic wounds. Hydrogel sponges were capable of preserving the characteristics of M2 macrophages, secreting functional cellular factors, and maintaining viability. Hydrogel sponges loaded with M2 type macrophages could promote chronic wound healing in the back of type 2 diabetic mice. In vitro and in vivo experiments demonstrated that M2 macrophages successfully grew and proliferated within the hydrogel sponges, exhibiting anti-inflammatory effects, which is expected to offer a cell therapy approach to diabetic wound treatment. Full article
(This article belongs to the Special Issue Hydrogels for Tissue Repair: Innovations and Applications)
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