Novel Hydrogels for Drug Delivery and Regenerative Medicine

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: 31 May 2026 | Viewed by 540

Special Issue Editors


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Guest Editor
College of Pharmacy, Jinan University, Guangzhou 510632, China
Interests: drug delivery systems; hydrogels; nano-targeted drug delivery technology
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Guest Editor
School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510275, China
Interests: transdermal drug delivery; pulmonary drug delivery; nanocarrier; molecular pharmaceutics
Special Issues, Collections and Topics in MDPI journals
School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China
Interests: development of novel drug delivery systems; hydrogels; brain-targeted and antimicrobial drug delivery platforms

Special Issue Information

Dear Colleagues,

Hydrogel-based systems have emerged as pivotal platforms in advancing drug delivery and regenerative medicine, owing to their unique biomimetic properties, tunable physicochemical characteristics, and exceptional biocompatibility. However, the design of hydrogels that simultaneously fulfill the complex demands of controlled drug release, mechanical robustness, cellular integration, and clinical translatability remains a significant multidisciplinary challenge. Recent innovations have explored stimuli-responsive networks, multifunctional composite architectures, 3D-bioprinted constructs, and spatially engineered microenvironments to enhance therapeutic precision and regenerative outcomes. Despite these promising developments, critical barriers continue to impede the full realization of hydrogel technologies in clinical practice.

This Special Issue seeks to highlight cutting-edge advances in the design, synthesis, functionalization, and application of next-generation hydrogel systems. We invite original research and reviews addressing advanced fabrication strategies (e.g., click chemistry, photopolymerization, 3D bioprinting), mechanisms of spatiotemporal drug release (e.g., targeted, sustained, or triggered delivery), integrated systems for combinatorial drug delivery and tissue regeneration (e.g., diabetic wounds, osteochondral defects, neural repair) and preclinical/clinical evaluation of therapeutic efficacy and biocompatibility. We welcome contributions that bridge fundamental material science with therapeutic applications, offering insights into overcoming existing limitations and accelerating the clinical adoption of hydrogel-based technologies.

This Special Issue is a joint Special Issue. Papers can be submitted to Gels or Pharmaceutics. Gels focus on physical (supramolecular) and chemical gel-based materials, while Pharmaceutics invites submissions related to drug delivery systems and innovative formulations.

Prof. Dr. Chuanbin Wu
Dr. Wenhao Wang
Dr. Jintao Fu
Guest Editors

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Keywords

  • hydrogels
  • drug delivery systems
  • regenerative medicine
  • therapeutics
  • controlled release

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Published Papers (1 paper)

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Review

28 pages, 3292 KB  
Review
Hydrogels as Promising Carriers for Ophthalmic Disease Treatment: A Comprehensive Review
by Wenxiang Zhu, Mingfang Xia, Yahui He, Qiuling Huang, Zhimin Liao, Xiaobo Wang, Xiaoyu Zhou and Xuanchu Duan
Gels 2026, 12(2), 105; https://doi.org/10.3390/gels12020105 - 27 Jan 2026
Viewed by 354
Abstract
Ocular disorders such as keratitis, glaucoma, age-related macular degeneration (AMD), diabetic retinopathy (DR), and dry eye disease (DED) are highly prevalent worldwide and remain major causes of visual impairment and blindness. Conventional therapeutic approaches for ocular diseases, such as eye drops, surgery, and [...] Read more.
Ocular disorders such as keratitis, glaucoma, age-related macular degeneration (AMD), diabetic retinopathy (DR), and dry eye disease (DED) are highly prevalent worldwide and remain major causes of visual impairment and blindness. Conventional therapeutic approaches for ocular diseases, such as eye drops, surgery, and laser therapy, are frequently hampered by limited drug bioavailability, rapid clearance, and treatment-related complications, primarily due to the eye’s unique anatomical and physiological barriers. Hydrogels, characterized by their three-dimensional network structure, high water content, excellent biocompatibility, and tunable physicochemical properties, have emerged as promising platforms for ophthalmic drug delivery. This review summarizes the classification, fabrication strategies, and essential properties of hydrogels, and highlights recent advances in their application to ocular diseases, including keratitis management, corneal wound repair, intraocular pressure regulation and neuroprotection in glaucoma, sustained drug delivery for AMD and DR, vitreous substitutes for retinal detachment, and therapies for DED. In particular, we highlight recent advances in stimuli-responsive hydrogels that enable spatiotemporally controlled drug release in response to ocular cues such as temperature, pH, redox state, and enzyme activity, thereby enhancing therapeutic precision and efficacy. Furthermore, this review critically evaluates translational aspects, including long-term ocular safety, clinical feasibility, manufacturing scalability, and regulatory challenges, which are often underrepresented in existing reviews. By integrating material science, ocular pathology, and translational considerations, this review aims to provide a comprehensive framework for the rational design of next-generation hydrogel systems and to facilitate their clinical translation in ophthalmic therapy. Full article
(This article belongs to the Special Issue Novel Hydrogels for Drug Delivery and Regenerative Medicine)
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