Table of Contents
J. Fungi, Volume 5, Issue 2 (June 2019)
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Cover Story (view full-size image) Low virulence Candida species can provide protection against lethal polymicrobial sepsis caused by [...] Read more. Low virulence Candida species can provide protection against lethal polymicrobial sepsis caused by Candida albicans and Staphylococcus aureus. We postulate that this protection is mediated by myeloid-derived suppressor cells (MDSCs) that expand in the bone marrow after primary (1˚) intraperitoneal challenge and are activated after a secondary (2˚) lethal challenge. This beneficial innate response, termed trained tolerogenic immunity, represents a novel form of trained innate immunity. View this paper.