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The Potential Role of Regenerative Medicine on the Future Management of Hypoplastic Left Heart Syndrome
 
 
Review

HLHS: Power of the Chick Model

by 1,2
1
Institute of Anatomy, First Faculty of Medicine, Charles University, 128 00 Prague, Czech Republic
2
Laboratory of Developmental Cardiology, Institute of Physiology, Czech Academy of Sciences, 142 20 Prague, Czech Republic
Academic Editor: Paul Grossfeld
J. Cardiovasc. Dev. Dis. 2022, 9(4), 113; https://doi.org/10.3390/jcdd9040113
Received: 30 January 2022 / Revised: 1 April 2022 / Accepted: 7 April 2022 / Published: 11 April 2022
Background: Hypoplastic left heart syndrome (HLHS) is a rare but deadly form of human congenital heart disease, most likely of diverse etiologies. Hemodynamic alterations such as those resulting from premature foramen ovale closure or aortic stenosis are among the possible pathways. Methods: The information gained from studies performed in the chick model of HLHS is reviewed. Altered hemodynamics leads to a decrease in myocyte proliferation causing hypoplasia of the left heart structures and their functional changes. Conclusions: Although the chick phenocopy of HLHS caused by left atrial ligation is certainly not representative of all the possible etiologies, it provides many useful hints regarding the plasticity of the genetically normal developing myocardium under altered hemodynamic loading leading to the HLHS phenotype, and even suggestions on some potential strategies for prenatal repair. View Full-Text
Keywords: left atrial ligation; left ventricular hypoplasia; hemodynamic alteration; myocyte proliferation; embryonic myocardium left atrial ligation; left ventricular hypoplasia; hemodynamic alteration; myocyte proliferation; embryonic myocardium
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MDPI and ACS Style

Sedmera, D. HLHS: Power of the Chick Model. J. Cardiovasc. Dev. Dis. 2022, 9, 113. https://doi.org/10.3390/jcdd9040113

AMA Style

Sedmera D. HLHS: Power of the Chick Model. Journal of Cardiovascular Development and Disease. 2022; 9(4):113. https://doi.org/10.3390/jcdd9040113

Chicago/Turabian Style

Sedmera, David. 2022. "HLHS: Power of the Chick Model" Journal of Cardiovascular Development and Disease 9, no. 4: 113. https://doi.org/10.3390/jcdd9040113

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