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Medicines, Volume 8, Issue 6

June 2021 - 8 articles

Cover Story: β-Thujaplicin has anticancer effects on various cancer cells via apoptosis. However, the apoptosis regulatory proteins involved in this process have yet to be revealed. We hypothesize that β-thujaplicin could act on XIAP both as a zinc chelator and as a XIAP-BIR3 inhibitor to induce and/or enhance apoptosis. It is revealed that β-thujaplicin enhances TRAIL-induced apoptosis in NCI-H460 NSCLC cells. β-Thujaplicin decreases the amount of XIAP in NCI-H460 cells and binds the XIAP-BIR3 domain at the Smac binding site. Our results validate β-thujaplicin as a potent seed compound that exerts dual effects on XIAP, i.e., XIAP inhibition by binding to the BIR3 domain and XIAP degradation. β-Thujaplicin represents a new scaffold for the development of novel types of XIAP-targeting anticancer drugs. View this paper

Articles (8)

  • Article
  • Open Access
5 Citations
6,011 Views
11 Pages
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Analgesic Effect of Combined Therapy with the Japanese Herbal Medicine “Yokukansan” and Electroacupuncture in Rats with Acute Inflammatory Pain

  • Nachi Ebihara,
  • Hideshi Ikemoto,
  • Naoki Adachi,
  • Takayuki Okumo,
  • Taro Kimura,
  • Kanako Yusa,
  • Satoshi Hattori,
  • Atsufumi Manabe,
  • Tadashi Hisamitsu and
  • Masataka Sunagawa
Medicines2021, 8(6), 31;https://doi.org/10.3390/medicines8060031

17 June 2021

Background: Japanese herbal medicine, called Kampo medicine, and acupuncture are mainly used in Japanese traditional medicine. In this experiment, the analgesic effect of Yokukansan (YKS) alone and a combination of YKS and electroacupuncture (EA) on...

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  • Review
  • Open Access
21 Citations
20,943 Views
20 Pages
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The Etiology and Pathophysiology Genesis of Benign Prostatic Hyperplasia and Prostate Cancer: A New Perspective

  • Teow J. Phua
Medicines2021, 8(6), 30;https://doi.org/10.3390/medicines8060030

11 June 2021

Background: The etiology of benign prostatic hyperplasia and prostate cancer are unknown, with ageing being the greatness risk factor. Methods: This new perspective evaluates the available interdisciplinary evidence regarding prostate ageing in terms...

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  • Perspective
  • Open Access
8 Citations
5,975 Views
7 Pages
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The Scientific and Cultural Journey to Ovarian Rejuvenation: Background, Barriers, and Beyond the Biological Clock

  • E. Scott Sills
Medicines2021, 8(6), 29;https://doi.org/10.3390/medicines8060029

8 June 2021

Female age has been known to define reproductive outcome since antiquity; attempts to improve ovarian function may be considered against a sociocultural landscape that foreshadows current practice. Ancient writs heralded the unlikely event of an olde...

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  • Article
  • Open Access
8 Citations
4,768 Views
16 Pages
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Anti-Tumor Effects of Ginsenoside 20(S)-Protopanaxadiol and 1,25-Dihydroxyvitamin D3 Combination in Castration Resistant Prostate Cancer

  • Mohamed Ben-Eltriki,
  • Subrata Deb,
  • Gehana Shankar,
  • Gray Meckling,
  • Mohamed Hassona,
  • Takeshi Yamazaki,
  • Ladan Fazli,
  • Mei Yieng Chin and
  • Emma S. Tomlinson Guns
Medicines2021, 8(6), 28;https://doi.org/10.3390/medicines8060028

4 June 2021

In spite of possessing desirable anticancer properties, currently, limited clinical success has been achieved with 20(S)-protopanaxadiol (aPPD) and 1,25-dihydroxyvitamin D3 (calcitriol). This study is designed to evaluate if the combination of aPPD w...

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  • Article
  • Open Access
4,013 Views
16 Pages
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Design, Syntheses, and Bioevaluations of Some Novel N2-Acryloylbenzohydrazides as Chemostimulants and Cytotoxic Agents

  • Kinjal Lakhani,
  • Edgar A. Borrego,
  • Karla G. Cano,
  • Jonathan R. Dimmock,
  • Renato J. Aguilera,
  • Swagatika Das,
  • Praveen K. Roayapalley,
  • Rajendra K. Sharma and
  • Umashankar Das
Medicines2021, 8(6), 27;https://doi.org/10.3390/medicines8060027

3 June 2021

A series of novel N2-acryloylhydrazides 1a–m and a related series of compounds 6a–c were prepared as potential chemostimulants. In general, these compounds are cytotoxic to human HCT 116 colon cancer cells, as well as human MCF-7 and MDA-MB-231 breas...

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  • Article
  • Open Access
5 Citations
5,089 Views
11 Pages
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β-Thujaplicin Enhances TRAIL-Induced Apoptosis via the Dual Effects of XIAP Inhibition and Degradation in NCI-H460 Human Lung Cancer Cells

  • Saki Seno,
  • Minori Kimura,
  • Yuki Yashiro,
  • Ryutaro Kimura,
  • Kanae Adachi,
  • Aoi Terabayashi,
  • Mio Takahashi,
  • Takahiro Oyama,
  • Hideaki Abe and
  • Takehiko Abe
  • + 2 authors
Medicines2021, 8(6), 26;https://doi.org/10.3390/medicines8060026

2 June 2021

Background: β-thujaplicin, a natural tropolone derivative, has anticancer effects on various cancer cells via apoptosis. However, the apoptosis regulatory proteins involved in this process have yet to be revealed. Methods: Trypan blue staining, a WST...

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  • Article
  • Open Access
6 Citations
5,332 Views
16 Pages
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The Role of Poly-Herbal Extract in Sodium Chloride-Induced Oxidative Stress and Hyperlipidemia in Male Wistar Rats

  • Olubukola Sinbad Olorunnisola,
  • Peter Ifeoluwa Adegbola,
  • Bamidele Stephen Ajilore,
  • Olayemi Adebola Akintola and
  • Olumide Samuel Fadahunsi
Medicines2021, 8(6), 25;https://doi.org/10.3390/medicines8060025

31 May 2021

Consistent consumption of high salt diet (HSD) has been associated with increased cellular generation of free radicals, which has been implicated in the derangement of some vital organs and etiology of cardiovascular disorders. This study was designe...

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  • Review
  • Open Access
9 Citations
20,325 Views
23 Pages
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Recognition and Management of Antipsychotic-Induced Parkinsonism in Older Adults: A Narrative Review

  • Sharadha Wisidagama,
  • Abiram Selladurai,
  • Peter Wu,
  • Marco Isetta and
  • Jordi Serra-Mestres
Medicines2021, 8(6), 24;https://doi.org/10.3390/medicines8060024

26 May 2021

Background: Parkinsonism is a common side-effect of antipsychotic drugs especially in older adults, who also present with a higher frequency of neurodegenerative disorders like Idiopathic Parkinson’s disease (IPD). Distinguishing between antipsychoti...

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