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Volume 10
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10.3390/toxics10050215
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Article

Amino-Functionalized Polystyrene Nano-Plastics Induce Mitochondria Damage in Human Umbilical Vein Endothelial Cells

by
Yiqi Fu
,
Mengqi Fan
,
Liwang Xu
,
Hui Wang
,
Qinglian Hu
* and
Yuanxiang Jin
*
College of Biotechnology and Bioengineering, Zhejiang University of Technology, Hangzhou 310032, China
*
Authors to whom correspondence should be addressed.
Toxics 2022, 10(5), 215; https://doi.org/10.3390/toxics10050215
Submission received: 23 March 2022 / Revised: 21 April 2022 / Accepted: 22 April 2022 / Published: 25 April 2022
(This article belongs to the Topic Emerging Contaminants in the Aquatic Environment)
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Abstract

As emerging contaminants, nano-plastics have become a major cause for concern for their adverse effects on the ecosystem and human health. The nano-sized properties of nano-plastics enable their exposure risks to humans through the food chain or other ways. However, the fate and adverse impact of nano-plastics on the human cardiovascular system are lacking. In this regard, the human umbilical vein endothelial cell line HUVEC was applied as a cell model to investigate the biological effects of noncharged polystyrene nano-plastics (PS NPs) and amino-functionalized nano-plastics (NH2-PS NPs). The positively charged PS NPs exhibited higher cytotoxicity to HUVEC, as evidenced by the decreased cell viability, enhanced ROS generation, and decreased mitochondria membrane potential triggered by NH2-PS NPs. Importantly, RT-PCR analysis revealed that NH2-PS NPs dysregulated the mitochondrial dynamics, replication, and function-related gene expression. This study demonstrated that NH2-PS NPs presented higher risks to endothelial cells than non-charged nano-plastics by interfering with mitochondria, which supported the direct evidence and expanded the potential risks of PS NPs.
Keywords: polystyrene nanoparticles; HUVEC; oxidative stress; mitochondria polystyrene nanoparticles; HUVEC; oxidative stress; mitochondria

Share and Cite

MDPI and ACS Style

Fu, Y.; Fan, M.; Xu, L.; Wang, H.; Hu, Q.; Jin, Y. Amino-Functionalized Polystyrene Nano-Plastics Induce Mitochondria Damage in Human Umbilical Vein Endothelial Cells. Toxics 2022, 10, 215. https://doi.org/10.3390/toxics10050215

AMA Style

Fu Y, Fan M, Xu L, Wang H, Hu Q, Jin Y. Amino-Functionalized Polystyrene Nano-Plastics Induce Mitochondria Damage in Human Umbilical Vein Endothelial Cells. Toxics. 2022; 10(5):215. https://doi.org/10.3390/toxics10050215

Chicago/Turabian Style

Fu, Yiqi, Mengqi Fan, Liwang Xu, Hui Wang, Qinglian Hu, and Yuanxiang Jin. 2022. "Amino-Functionalized Polystyrene Nano-Plastics Induce Mitochondria Damage in Human Umbilical Vein Endothelial Cells" Toxics 10, no. 5: 215. https://doi.org/10.3390/toxics10050215

APA Style

Fu, Y., Fan, M., Xu, L., Wang, H., Hu, Q., & Jin, Y. (2022). Amino-Functionalized Polystyrene Nano-Plastics Induce Mitochondria Damage in Human Umbilical Vein Endothelial Cells. Toxics, 10(5), 215. https://doi.org/10.3390/toxics10050215

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