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Case Report

Are We Losing Awareness of Other Infections Due to the Fear of Coronavirus Disease-2019 and Mis-C?

by
Gökçen Erfidan
1,
Özgür Özdemir Şimşek
1,
Ahu Kara Aksay
2,
Gülnihan Üstündağ
2,
Seçil Arslansoyu Çamlar
3,
Fatma Mutlubaş
3,
Dilek Yılmaz Çiftdoğan
4,
Belde Kasap Demir
5 and
Demet Alaygut
3
1
Department of Pediatric Nephrology, University of Health Sciences, İzmir Tepecik Training and Research Hospital, Gaziler Street No:1, Yenisehir, Izmir 35020, Turkey
2
Department of Pediatric Infectious Diseases, University of Health Sciences, İzmir Tepecik Training and Research Hospital, Gaziler Street No:1, Yenisehir, Izmir 35020, Turkey
3
Department of Pediatric Nephrology, Izmir Faculty of Medicine, University of Health Sciences, Kazım Dirik, Sanayi Cad. No:7, Bornova, Izmir 35000, Turkey
4
Department of Pediatric Infectious Disease, Faculty of Medicine, Izmir Katip Çelebi University, Aydinlikevler, 6782. St. No:53, Çiğli, Izmir 35640, Turkey
5
Department of Pediatric Nephrology and Rheumatology, Faculty of Medicine, Izmir Katip Çelebi University, Aydinlikevler, 6782. St. No:53, Çiğli, Izmir 35640, Turkey
GERMS 2021, 11(4), 617-624; https://doi.org/10.18683/germs.2021.1299
Submission received: 4 July 2021 / Revised: 15 November 2021 / Accepted: 23 November 2021 / Published: 29 December 2021

Abstract

Introduction: Multisystem inflammatory syndrome in children (MIS-C) is a rarely seen severe complication of coronavirus disease-2019 (COVID-19). Although fever is one of the indispensable symptoms, other infections should be considered in the differential diagnosis during the pandemic. Case report: An 8-year-old and a 16-year-old female patient were admitted with fever, vomiting, headache. Both had fulfilled the criteria and were diagnosed with MIS-C. However, they both had remarkable persistent costovertebral angle tenderness, which was unexpected in MIS-C. In Case-1, urine analysis showed microscopic hematuria without pyuria, and urine culture showed no bacterial growth. Case-2 had microscopic hematuria and pyuria with Escherichia coli growth in urine culture. Contrast-enhanced computed tomography showed wedge-shaped hypodense multiple lesions in bilateral kidneys for Case-1, in the right kidney for Case-2. They diagnosed acute focal bacterial nephritis (AFBN). Conclusions: The diagnostic criteria of MIS-C can overlap with the symptoms of other severe septic infections such as AFBN, which is a rare urinary tract infection, diagnosed by imaging of localized renal inflammatory mass-like or wedge-shaped lesion. A detailed anamnesis and careful physical examination may help differential diagnosis.
Keywords: MIS-C; fever; acute focal bacterial nephritis; costovertebral angle tenderness; flank pain MIS-C; fever; acute focal bacterial nephritis; costovertebral angle tenderness; flank pain

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MDPI and ACS Style

Erfidan, G.; Şimşek, Ö.Ö.; Aksay, A.K.; Üstündağ, G.; Çamlar, S.A.; Mutlubaş, F.; Çiftdoğan, D.Y.; Demir, B.K.; Alaygut, D. Are We Losing Awareness of Other Infections Due to the Fear of Coronavirus Disease-2019 and Mis-C? GERMS 2021, 11, 617-624. https://doi.org/10.18683/germs.2021.1299

AMA Style

Erfidan G, Şimşek ÖÖ, Aksay AK, Üstündağ G, Çamlar SA, Mutlubaş F, Çiftdoğan DY, Demir BK, Alaygut D. Are We Losing Awareness of Other Infections Due to the Fear of Coronavirus Disease-2019 and Mis-C? GERMS. 2021; 11(4):617-624. https://doi.org/10.18683/germs.2021.1299

Chicago/Turabian Style

Erfidan, Gökçen, Özgür Özdemir Şimşek, Ahu Kara Aksay, Gülnihan Üstündağ, Seçil Arslansoyu Çamlar, Fatma Mutlubaş, Dilek Yılmaz Çiftdoğan, Belde Kasap Demir, and Demet Alaygut. 2021. "Are We Losing Awareness of Other Infections Due to the Fear of Coronavirus Disease-2019 and Mis-C?" GERMS 11, no. 4: 617-624. https://doi.org/10.18683/germs.2021.1299

APA Style

Erfidan, G., Şimşek, Ö. Ö., Aksay, A. K., Üstündağ, G., Çamlar, S. A., Mutlubaş, F., Çiftdoğan, D. Y., Demir, B. K., & Alaygut, D. (2021). Are We Losing Awareness of Other Infections Due to the Fear of Coronavirus Disease-2019 and Mis-C? GERMS, 11(4), 617-624. https://doi.org/10.18683/germs.2021.1299

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