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Processes 2017, 5(4), 86; https://doi.org/10.3390/pr5040086

Systematic and Model-Assisted Evaluation of Solvent Based- or Pressurized Hot Water Extraction for the Extraction of Artemisinin from Artemisia annua L.

Institute for Separation and Process Technology, Clausthal University of Technology, 38678 Clausthal-Zellerfeld, Germany
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Received: 24 November 2017 / Revised: 12 December 2017 / Accepted: 15 December 2017 / Published: 20 December 2017
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Abstract

In this study, the solvent based extraction of artemisinin from Artemisia annua L. using acetone in percolation mode is compared to the method of pressurized hot water extraction. Both techniques are simulated by a physico-chemical process model. The model as well as the model parameter determination, including the thermal degradation of artemisinin are shown and discussed. For the conventional extraction, a solvent screening is performed considering various organic solvents. A temperature screening is presented for the systematic design of the pressurized hot water extraction. The best temperature with regards to thermal decomposition and high productivity was found to be 80 °C. Both, conventional percolation and Pressurized Hot Water Extraction (PHWE) are suitable for the extraction of artemisinin. The extraction curves show a high conformity with the simulation results. View Full-Text
Keywords: artemisinin; extraction; modeling; simulation; Green Solvents; Pressurized Hot Water Extraction artemisinin; extraction; modeling; simulation; Green Solvents; Pressurized Hot Water Extraction
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Sixt, M.; Strube, J. Systematic and Model-Assisted Evaluation of Solvent Based- or Pressurized Hot Water Extraction for the Extraction of Artemisinin from Artemisia annua L.. Processes 2017, 5, 86.

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