You are currently viewing a new version of our website. To view the old version click .

Biomedicines, Volume 11, Issue 2

February 2023 - 412 articles

Cover Story: Cysteine cathepsins, abundantly present in the lysosomes, play a vital role in several immune processes. In pathological conditions, their activity is dysregulated, which causes harmful inflammatory processes leading to autoimmune diseases. The activity of cathepsins is especially complicated in immune response to cancer, where they can stimulate immune processes and help in cancer elimination, or suppress immune response and contribute to cancer propagation. Understanding the molecular mechanisms of their actions is necessary for the successful design of cathepsins’ inhibitors. View this paper
  • Issues are regarded as officially published after their release is announced to the table of contents alert mailing list .
  • You may sign up for email alerts to receive table of contents of newly released issues.
  • PDF is the official format for papers published in both, html and pdf forms. To view the papers in pdf format, click on the "PDF Full-text" link, and use the free Adobe Reader to open them.

Articles (412)

  • Article
  • Open Access
13 Citations
3,275 Views
9 Pages

First Live-Experience Session with PET/CT Specimen Imager: A Pilot Analysis in Prostate Cancer and Neuroendocrine Tumor

  • Lorenzo Muraglia,
  • Francesco Mattana,
  • Laura Lavinia Travaini,
  • Gennaro Musi,
  • Emilio Bertani,
  • Giuseppe Renne,
  • Eleonora Pisa,
  • Mahila Esmeralda Ferrari,
  • Uberto Fumagalli Romario and
  • Ottavio De Cobelli
  • + 2 authors

Objective: to evaluate the feasibility of the intra-operative application of a specimen PET/CT imager in a clinical setting. Materials and methods: this is a pilot analysis performed in three patients who received an intra-operative administration of...

  • Review
  • Open Access
40 Citations
5,728 Views
19 Pages

Novel Adipokines and Their Role in Bone Metabolism: A Narrative Review

  • Fnu Deepika,
  • Siresha Bathina and
  • Reina Armamento-Villareal

The growing burden of obesity and osteoporosis is a major public health concern. Emerging evidence of the role of adipokines on bone metabolism has led to the discovery of novel adipokines over the last decade. Obesity is recognized as a state of adi...

  • Article
  • Open Access
8 Citations
3,467 Views
23 Pages

Molecular Screening of Bioactive Compounds of Garlic for Therapeutic Effects against COVID-19

  • Huma Ashraf,
  • Erum Dilshad,
  • Tayyaba Afsar,
  • Ali Almajwal,
  • Huma Shafique and
  • Suhail Razak

An outbreak of pneumonia occurred on December 2019 in Wuhan, China, which caused a serious public health emergency by spreading around the globe. Globally, natural products are being focused on more than synthetic ones. So, keeping that in view, the...

  • Review
  • Open Access
6 Citations
8,002 Views
19 Pages

Immune Recognition versus Immune Evasion Systems in Zika Virus Infection

  • Yee Teng Chan,
  • Yi Ying Cheok,
  • Heng Choon Cheong,
  • Ting Fang Tang,
  • Sofiah Sulaiman,
  • Jamiyah Hassan,
  • Chung Yeng Looi,
  • Kim-Kee Tan,
  • Sazaly AbuBakar and
  • Won Fen Wong

The reemergence of the Zika virus (ZIKV) infection in recent years has posed a serious threat to global health. Despite being asymptomatic or mildly symptomatic in a majority of infected individuals, ZIKV infection can result in severe manifestations...

  • Article
  • Open Access
8 Citations
3,360 Views
13 Pages

The Iron Content of Human Serum Albumin Modulates the Susceptibility of Acinetobacter baumannii to Cefiderocol

  • Jenny Escalante,
  • Brent Nishimura,
  • Marisel R. Tuttobene,
  • Tomás Subils,
  • Vyanka Mezcord,
  • Luis A. Actis,
  • Marcelo E. Tolmasky,
  • Robert A. Bonomo and
  • María Soledad Ramirez

The mortality rates of patients infected with Acinetobacter baumannii who were treated with cefiderocol (CFDC) were not as favorable as those receiving the best available treatment for pulmonary and bloodstream infections. Previous studies showed tha...

  • Article
  • Open Access
52 Citations
6,673 Views
21 Pages

The Effects of Probiotics on Small Intestinal Microbiota Composition, Inflammatory Cytokines and Intestinal Permeability in Patients with Non-Alcoholic Fatty Liver Disease

  • Nurainina Ayob,
  • Khairul Najmi Muhammad Nawawi,
  • Mohamad Hizami Mohamad Nor,
  • Raja Affendi Raja Ali,
  • Hajar Fauzan Ahmad,
  • Seok Fang Oon and
  • Norfilza Mohd Mokhtar

The prevalence of non-alcoholic fatty liver disease (NAFLD) has soared globally. As our understanding of the disease grows, the role of the gut-liver axis (GLA) in NAFLD pathophysiology becomes more apparent. Hence, we focused mainly on the small int...

  • Review
  • Open Access
37 Citations
8,155 Views
16 Pages

Targeted Therapy Development in Acute Myeloid Leukemia

  • Tulasigeri M. Totiger,
  • Anirban Ghoshal,
  • Jenna Zabroski,
  • Anya Sondhi,
  • Saanvi Bucha,
  • Jacob Jahn,
  • Yangbo Feng and
  • Justin Taylor

Therapeutic developments targeting acute myeloid leukemia (AML) have been in the pipeline for five decades and have recently resulted in the approval of multiple targeted therapies. However, there remains an unmet need for molecular treatments that c...

  • Article
  • Open Access
6 Citations
3,847 Views
22 Pages

Phenotypic Characterization of Male Tafazzin-Knockout Mice at 3, 6, and 12 Months of Age

  • Michelle V. Tomczewski,
  • John Z. Chan,
  • Zurie E. Campbell,
  • Douglas Strathdee and
  • Robin E. Duncan

Barth syndrome (BTHS) is an X-linked mitochondrial disease caused by mutations in the gene encoding for tafazzin (TAZ), a key enzyme in the remodeling of cardiolipin. Mice with a germline deficiency in Taz have been generated (Taz-KO) but not yet ful...

  • Article
  • Open Access
1 Citations
2,547 Views
9 Pages

Risk of Severe Alphaherpesvirus Infection after Solid Organ Transplantation: A Nationwide Population-Based Cohort Study

  • Ya-Wen Chuang,
  • Shih-Ting Huang,
  • I-Kuan Wang,
  • Ying-Chih Lo,
  • Chiz-Tzung Chang,
  • Cheng-Li Lin,
  • Tung-Min Yu and
  • Chi-Yuan Li

Patients after solid organ transplantation (SOT) are more susceptible to various viral infections, including alphaherpesviruses. Therefore, the aim of our study was to investigate the risk of alphaherpesvirus infections, including herpes simplex and...

  • Article
  • Open Access
16 Citations
4,332 Views
13 Pages

Influence of FOSL1 Inhibition on Vascular Calcification and ROS Generation through Ferroptosis via P53-SLC7A11 Axis

  • Sisi Shao,
  • Yaoxin Liu,
  • Wanzi Hong,
  • Yuanxi Mo,
  • Fen Shu,
  • Lei Jiang and
  • Ning Tan

Background: Vascular calcification during aging is highly prevalent in patients with cardiovascular disease; however, there is still no improvement in clarifying the development of vascular calcification. FOSL1 is a transcription regulator belonging...

of 42

Get Alerted

Add your email address to receive forthcoming issues of this journal.

XFacebookLinkedIn
Biomedicines - ISSN 2227-9059