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Biomedicines, Volume 11, Issue 3

March 2023 - 346 articles

Cover Story: Sepsis and septic shock are among the deadliest diseases, responsible for an estimated annual global death toll of 11 million. Sepsis is a complex disorder involving a disbalance between inflammation and anti-inflammation, leading to the widespread unregulated release of inflammatory mediators, cytokines, and pathogen-related molecules, prominent in systemwide organ dysfunction. Unfortunately, rising antibiotic resistance among bacteria and a dwindling pipeline of newer antibiotics make its treatment difficult. To rise to this challenge, monoclonal antibodies as an alternative therapy have garnered substantial attention in recent years and may provide the solution to obliterate sepsis. View this paper
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Articles (346)

  • Article
  • Open Access
7 Citations
4,552 Views
11 Pages

Vitamin A Deficiency and Its Association with Visceral Adiposity in Women

  • Érica Góes,
  • Adryana Cordeiro,
  • Claudia Bento and
  • Andrea Ramalho

Body adiposity is associated with increased metabolic risk, and evidence indicates that vitamin A is important in regulating body fat. The aim of this study was to evaluate serum concentrations of vitamin A and its association with body adiposity in...

  • Review
  • Open Access
2 Citations
3,864 Views
20 Pages

Structure-Guided Prediction of the Functional Impact of DCLK1 Mutations on Tumorigenesis

  • Annalisa L. E. Carli,
  • Joshua M. Hardy,
  • Hanadi Hoblos,
  • Matthias Ernst,
  • Isabelle S. Lucet and
  • Michael Buchert

Doublecortin-like kinase 1 (DCLK1) is a functional serine/threonine (S/T)-kinase and a member of the doublecortin family of proteins which are characterized by their ability to bind to microtubules (MTs). DCLK1 is a proposed cancer driver gene, and i...

  • Article
  • Open Access
1 Citations
2,487 Views
11 Pages

Obesity and recurrent hematuria are known risk factors for chronic kidney disease. However, there has been controversy on the association between obesity and glomerular hematuria. This study aimed to investigate the association between body mass inde...

  • Case Report
  • Open Access
2 Citations
2,589 Views
20 Pages

Bacillary Layer Detachment in Neovascular Age-Related Macular Degeneration: Case Series

  • Filomena Palmieri,
  • Saad Younis,
  • Walid Raslan and
  • Lorenzo Fabozzi

Purpose: This study seeks to report the clinical and multimodal imaging findings of eight eyes of seven patients with neovascular age-related macular degeneration (nAMD) who developed bacillary layer detachment (BALAD). Setting/Venue: The patients we...

  • Article
  • Open Access
3 Citations
2,638 Views
19 Pages

Adipose-Derived Stromal Cells within a Gelatin Matrix Acquire Enhanced Regenerative and Angiogenic Properties: A Pre-Clinical Study for Application to Chronic Wounds

  • Nicolo Costantino Brembilla,
  • Ali Modarressi,
  • Dominik André-Lévigne,
  • Estelle Brioudes,
  • Florian Lanza,
  • Hubert Vuagnat,
  • Stéphane Durual,
  • Laurine Marger,
  • Wolf-Henning Boehncke and
  • Karl-Heinz Krause
  • + 1 author

This study evaluates the influence of a gelatin sponge on adipose-derived stromal cells (ASC). Transcriptomic data revealed that, compared to ASC in a monolayer, a cross-linked porcine gelatin sponge strongly influences the transcriptome of ASC. Woun...

  • Communication
  • Open Access
2 Citations
2,197 Views
8 Pages

The adoption of an automated system can decrease the hands-on time requirements in a clinical laboratory setting. For the detection of HLA-B*27, implementing a high-throughput and fully automated system has several advantages over using manual method...

  • Article
  • Open Access
4 Citations
2,728 Views
22 Pages

Tissue-resident macrophages (Mø) play tissue/organ-specific roles, and the physiological/pathological implications of uterine Mø in fertility and infertility are not yet fully understood. Herein, we report a simple propagation method fo...

  • Case Report
  • Open Access
1 Citations
4,540 Views
6 Pages

Surgical Management of Pterygium Colli with Significant Skin Laxity: A Case Report

  • Charline Huttin,
  • Patrick Ringenbach,
  • Anastasia Durry,
  • Mihai Hogas,
  • Ionut Raducu Popescu,
  • Alin Ciobica and
  • Mihaela Elena Nastasa

Pterygium Colli or “palmate neck” is a congenital malformation that is most often part of a polimalformative syndrome. This deformity is a source of aesthetic and social embarrassment. Its correction is surgical. We present the case of a...

  • Article
  • Open Access
2 Citations
2,617 Views
11 Pages

Identification of a Novel Protein-Based Prognostic Model in Gastric Cancers

  • Zhijuan Xiong,
  • Chutian Xing,
  • Ping Zhang,
  • Yunlian Diao,
  • Chenxi Guang,
  • Ying Ying and
  • Wei Zhang

Gastric cancer (GC) is the third leading cause of cancer-related deaths worldwide. However, there are still no reliable biomarkers for the prognosis of this disease. This study aims to construct a robust protein-based prognostic prediction model for...

  • Article
  • Open Access
4 Citations
2,793 Views
12 Pages

Immunohistochemical Evaluation of Candidate Biomarkers for Fluorescence-Guided Surgery of Myxofibrosarcoma Using an Objective Scoring Method

  • Zeger Rijs,
  • Esther Belt,
  • Gijsbert M. Kalisvaart,
  • Cornelis F. M. Sier,
  • Peter J. K. Kuppen,
  • Arjen H. G. Cleven,
  • Alexander L. Vahrmeijer,
  • Michiel A. J. van de Sande and
  • Pieter B. A. A. van Driel

Introduction: Myxofibrosarcoma (MFS) is the most common soft-tissue sarcoma subtype in elderly patients. Local recurrence (LR) remains a major concern as the lack of intraoperative guidance and an infiltrative growth pattern with long, slender tails...

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Biomedicines - ISSN 2227-9059Creative Common CC BY license