Special Issue "Microbial Ecology in Health and Disease 2.0"

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Microbiology in Human Health and Disease".

Deadline for manuscript submissions: 15 June 2022.

Special Issue Editors

Prof. Dr. Eugenia Bezirtzoglou
E-Mail Website
Guest Editor
Laboratory of Hygiene and Environmental Protection 68100-Panepistimioupolis, Democritus University of Thrace Medical School, Alexandroupolis, Greece
Interests: microbial ecology; health; disease; microbiota; hygiene; environment; food; antibiotics; probiotics; diet; antimicrobials
Special Issues, Collections and Topics in MDPI journals
Dr. Elisavet Stavropoulou
Guest Editor
Department of Infectious Diseases, CHUV (Centre Hospitalier Universitaire Vaudois), 1011 Lausanne, Switzerland
Interests: infectious diseases; antibiotics; probiotics; microbial ecology; health; disease; microbiota; hygiene; antibiotics; probiotics; diet; intestine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue will collect research on the different human microbial ecosystems to illuminate their role in health and disease. This field of research has drawn increased attention in recent years as scientists have helped to advance our knowledge of the normal microbial flora, “the microbiome”, and its role in infection. Nevertheless, the disastrous effects of the different medical or other technical, chemical substances and antibiotics closely related to the alterations of the microbiota are attracting more and more attention.

Medicinal and aromatic plants play a central role, not only as traditional medicines in tackling diseases but also in the treatment of gastrointestinal disorders and other clinical states interacting with gut microbiota.

This Special Issue will consider manuscripts on the different aspects of microbial ecology in health and disease, focusing on the human and animal microbiotas as well as on food and environmental ecosystems, which may be of interest in terms of preserving public health.

The role of antibiotics, antimicrobials, probiotics, supplements, or diet on the human microbiota, inducing deleterious or benefic modifications, will be considered for publication.

The immunological status, induced mechanisms, and interactions which determine the human microflora, as well as clinical microflora applications in treatment and prevention of disease, will be of interest.

Lastly, microbial communities and ecosystems of any organism or environment will be of interest for their role in improving public health.

Prof. Dr. Eugenia Bezirtzoglou
Dr. Elisavet Stavropoulou
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • microbial ecology
  • health
  • disease
  • microbiota
  • hygiene
  • environment
  • food
  • antibiotics
  • diet
  • probiotics
  • antimicrobials

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Published Papers (1 paper)

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Genomic and Phylogenetic Analysis of Lactiplantibacillus plantarum L125, and Evaluation of Its Anti-Proliferative and Cytotoxic Activity in Cancer Cells
Biomedicines 2021, 9(11), 1718; https://doi.org/10.3390/biomedicines9111718 - 19 Nov 2021
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Lactiplantibacillus plantarum is a diverse species that includes nomadic strains isolated from a variety of environmental niches. Several L. plantarum strains are being incorporated in fermented foodstuffs as starter cultures, while some of them have also been characterized as probiotics. In this study, [...] Read more.
Lactiplantibacillus plantarum is a diverse species that includes nomadic strains isolated from a variety of environmental niches. Several L. plantarum strains are being incorporated in fermented foodstuffs as starter cultures, while some of them have also been characterized as probiotics. In this study, we present the draft genome sequence of L. plantarum L125, a potential probiotic strain presenting biotechnological interest, originally isolated from a traditional fermented meat product. Phylogenetic and comparative genomic analysis with other potential probiotic L. plantarum strains were performed to determine its evolutionary relationships. Furthermore, we located genes involved in the probiotic phenotype by whole genome annotation. Indeed, genes coding for proteins mediating host–microbe interactions and bile salt, heat and cold stress tolerance were identified. Concerning the potential health-promoting attributes of the novel strain, we determined that L. plantarum L125 carries an incomplete plantaricin gene cluster, in agreement with previous in vitro findings, where no bacteriocin-like activity was detected. Moreover, we showed that cell-free culture supernatant (CFCS) of L. plantarum L125 exerts anti-proliferative, anti-clonogenic and anti-migration activity against the human colon adenocarcinoma cell line, HT-29. Conclusively, L. plantarum L125 presents desirable probiotic traits. Future studies will elucidate further its biological and health-related properties. Full article
(This article belongs to the Special Issue Microbial Ecology in Health and Disease 2.0)
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