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Volume 10
Issue 4
10.3390/biomedicines10040892
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Article

Hepatic Steatosis Is Associated with High White Blood Cell and Platelet Counts

by
Yu-Lin Chao
1,
Pei-Yu Wu
1,2,
Jiun-Chi Huang
1,2,3,
Yi-Wen Chiu
1,3,
Jia-Jung Lee
1,3,
Szu-Chia Chen
1,2,3,4,*,
Jer-Ming Chang
1,3,*,
Shang-Jyh Hwang
1,3 and
Hung-Chun Chen
1,3
1
Division of Nephrology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan
2
Department of Internal Medicine, Kaohsiung Municipal Siaogang Hospital, Kaohsiung Medical University, Kaohsiung 812, Taiwan
3
Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
4
Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan
*
Authors to whom correspondence should be addressed.
Biomedicines 2022, 10(4), 892; https://doi.org/10.3390/biomedicines10040892
Submission received: 12 March 2022 / Revised: 11 April 2022 / Accepted: 12 April 2022 / Published: 13 April 2022
(This article belongs to the Special Issue NAFLD: From Mechanisms to Therapeutic Approaches)
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Abstract

The incidence of hepatic steatosis is increasing globally, and it is important to identify those at risk to prevent comorbidities. Complete blood count is a simple, convenient, and inexpensive laboratory examination which can be used to obtain white blood cell (WBC) and platelet counts. The aims of this study were to investigate the relationships between WBC and platelet counts with hepatic steatosis, and whether WBC and platelet counts were associated with the severity of hepatic steatosis. We enrolled 1969 participants residing in southern Taiwan who took part in a health survey from June 2016 to September 2018 in this cross-sectional study. None of the participants were heavy alcohol users or had a history of hepatitis B or C. We collected laboratory data, and the severity of hepatic steatosis was determined by abdominal ultrasound. The overall prevalence rate of hepatic steatosis was 42.0%. There were significant trends of stepwise increases in WBC count (p < 0.001) corresponding to the severity of hepatic steatosis. After multivariable linear regression analysis, hepatic steatosis was significantly associated with high WBC count (coefficient β, 0.209; 95% confidence interval (CI), 0.055 to 0.364; p = 0.008) and high platelet count (coefficient β, 12.213; 95% CI, 6.092 to 18.334; p < 0.001); also, higher WBC counts corresponded with the severity of hepatic steatosis.
Keywords: hepatic steatosis; white blood cell; platelet hepatic steatosis; white blood cell; platelet

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MDPI and ACS Style

Chao, Y.-L.; Wu, P.-Y.; Huang, J.-C.; Chiu, Y.-W.; Lee, J.-J.; Chen, S.-C.; Chang, J.-M.; Hwang, S.-J.; Chen, H.-C. Hepatic Steatosis Is Associated with High White Blood Cell and Platelet Counts. Biomedicines 2022, 10, 892. https://doi.org/10.3390/biomedicines10040892

AMA Style

Chao Y-L, Wu P-Y, Huang J-C, Chiu Y-W, Lee J-J, Chen S-C, Chang J-M, Hwang S-J, Chen H-C. Hepatic Steatosis Is Associated with High White Blood Cell and Platelet Counts. Biomedicines. 2022; 10(4):892. https://doi.org/10.3390/biomedicines10040892

Chicago/Turabian Style

Chao, Yu-Lin, Pei-Yu Wu, Jiun-Chi Huang, Yi-Wen Chiu, Jia-Jung Lee, Szu-Chia Chen, Jer-Ming Chang, Shang-Jyh Hwang, and Hung-Chun Chen. 2022. "Hepatic Steatosis Is Associated with High White Blood Cell and Platelet Counts" Biomedicines 10, no. 4: 892. https://doi.org/10.3390/biomedicines10040892

APA Style

Chao, Y.-L., Wu, P.-Y., Huang, J.-C., Chiu, Y.-W., Lee, J.-J., Chen, S.-C., Chang, J.-M., Hwang, S.-J., & Chen, H.-C. (2022). Hepatic Steatosis Is Associated with High White Blood Cell and Platelet Counts. Biomedicines, 10(4), 892. https://doi.org/10.3390/biomedicines10040892

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