Skip to Content
HealthcareHealthcare
  • Systematic Review
  • Open Access

6 February 2026

Analysis of the Multifactorial Risks of Postpartum Urinary Incontinence: A Systematic Review

,
,
,
,
and
1
Midwifery Department, School of Health and Care Sciences, University of West Attica, 12243 Athens, Greece
2
Neonatal Intensive Care Unit, General Hospital of Nikaia “Agios Panteleimon”, 18454 Athens, Greece
*
Author to whom correspondence should be addressed.

Abstract

Introduction: Urinary incontinence (UI) is one of the most common pelvic floor disorders after childbirth and depends on hormonal changes, anatomical damage that occurs after childbirth, muscle and connective tissue weakness, fascia and nerves. UI is distinguished into three subtypes, including stress urinary incontinence (SUI), urgent urinary incontinence (UUI) and mixed urinary incontinence (MUI). Aim: The purpose of this review is to collect and summarize the results of studies related to the risk factors of urinary incontinence, to disseminate this information to scientists so that this major issue can be prevented, identified and managed. Methodology: This review followed the methodology of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and PECO eligibility criteria were used. We included studies published up to 2025 and not before 2019. The review was limited to studies published within the last six years in order to reflect contemporary diagnostic criteria, assessment tools and current postpartum care practices related to urinary incontinence. We searched PubMed, Google Scholar and Scopus for studies concerning the relationship between risk factors and postpartum UI. Results: A total of 1321 citations were identified. Following our exclusion criteria, 36 papers were selected to identify the risk factors for UI. All the research focused on the associated factors of any type of urinary incontinence. Vaginal and instrumental delivery, obesity, maternal age and the neonate’s birth weight were the main risk factors. The multiparity and incontinence symptoms before and during pregnancy were also strong risk factors. Heterogeneity across studies in assessment tools, in outcome measures and timing of postpartum assessment are some of the limitations of the study. Restriction to English-language publications and the absence of protocol registration were some of the additional limitations of the study. Conclusions: This problem affects the inclusion of women in society, the family, limits social activities and even their ability to work. Detection of the type of urinary incontinence by healthcare professionals, lifestyle modifications, monitoring women’s body weight and encouraging them to follow a program of pelvic floor muscle exercises should be a priority for professionals. The strategy of developing prognostic models in the coming years will be the only way to ensure the early identification and follow-up of women at high risk for urinary disorders.

1. Introduction

Urinary incontinence is a multifactorial health problem. In addition to pelvic organ prolapse and fecal incontinence, urinary incontinence is one of the most common pelvic floor disorders after childbirth and depends on hormonal changes, anatomical damage that occurs after birth, muscle and connective tissue weakness, fascia and nerves [1,2]. Urinary incontinence may be the result of bladder or sphincter dysfunction or both [3]. Hormonal changes during pregnancy, accompanied by weakened bladder neck support, contribute to a change in the pelvic floor support structure [4]. During that period, reduced muscle strength of the pelvic floor muscles, abnormal contractility of the urethra and relaxation of the pelvic ligaments are observed. Urinary incontinence (UI), according to the International Urinary Incontinence Society (ICS), is any involuntary loss of urine, and its severity is determined by frequency and type of leakage, confounding factors, impact on hygiene, social impact and impact on the woman’s quality of life with or without health care seeking.
Several guidelines argue that symptom reporting and self-assessment by women themselves can accurately reflect the severity of urinary incontinence symptoms without requiring measurement of the weight of the incontinence pads [5]. Some women perceive urinary incontinence as an expected symptom of childbearing, while for other women it is a social stigma. UI is distinguished into three subtypes, including stress urinary incontinence (SUI), urgent urinary incontinence (UUI) and mixed urinary incontinence (MUI) [6].
SUI is the main type of urinary incontinence, mainly in young and middle-aged women. It is caused by dysfunction of the internal urethral sphincter and pelvic floor muscles, relaxation of the fascia and ligaments and high mobility of the urethra [5]. Its appearance can be triggered by stressful situations such as childbirth and weight gain [5]. SUI is the most common form of incontinence in women of reproductive age, with an incidence of 5% to 60% worldwide [7]. It occurs after physical exertion such as running, jumping, any physical exercise, coughing, or sneezing [8,9]. It has been observed that healthy women with proper urinary continence before pregnancy will experience SUI in 15–21% [10].
Women who develop postpartum SUI have been observed to have increased bladder-neck mobility before delivery compared with those without urinary incontinence [11]. Women who experience SUI after childbirth may not return to normal function and may have permanent urinary incontinence, specifically urge urinary incontinence (UUI). In particular, studies have shown that in women who experienced urinary incontinence 3 months after childbirth, these symptoms persisted even after 6 and 12 years by 24% and 38%, respectively [12]. The study by Ferrari et al. revealed that women who performed Pelvic Floor Muscle Training (PFMT) during pregnancy rather than only in the postpartum period were at lower risk of having symptoms of SUI [13].
UUI is characterized by an urgent need to urinate that cannot be postponed, followed by an involuntary loss of urine and nocturia or frequent urination [14]. A systematic review of 22 studies showed that UUI occurs in 1.8% to 30.5% in Europe, 1.7% to 36.4% in the USA and 1.5% to 15.2% in Asia [5]. The appearance of this particular subtype is associated with age, with a greater worsening of symptoms in women near the age of 70. Its symptoms can cause intense anxiety and depression and have a negative effect on the quality of life of these women [5].
Mixed UI is the most common form of urinary incontinence that combines the two previous subtypes. Its prevalence increases with age and tends to be more common in women aged > 65 years. MUI has the greatest impact on quality of life. The symptoms tend to worsen rather than improve. Studies have reported low remission rates. Only 8% of women with mild or moderate MUI will experience complete remission after 4 years of follow-up [5].
Worldwide, rates of urinary incontinence range from 15 to 52%, with a higher incidence in women, which has a significant impact on quality of life (QOL) [15]. Studies have shown that the problem gets worse in pregnancy and is observed in 30–35% during the third trimester [16]. Changes in the neuromuscular function of the urethral sphincter during pregnancy that may persist postpartum increase the likelihood of urinary incontinence [17]. The risk of urinary incontinence after childbirth, especially in the 4–18 months after childbirth, doubles in women who experience incontinence during pregnancy [11,18].
During the postpartum period, the rates range from 7 to 12% [19]. Approximately 34.3% of women worldwide experience urinary incontinence, while 8.5% of these women need to use pads on a daily basis [20]. In relation to primiparous women, studies have shown that during the first 12 months after giving birth, 55% of primiparous women will experience urinary incontinence [21]. Some cases of urinary incontinence are temporary and the symptoms subside after three months have passed since delivery. But if these symptoms persist, the chances increase to 92% that the problem will persist 5 years later [22].
Worldwide, reported rates of urinary incontinence in women aged 20 years and older are 45% in the USA, 46% in Australia, 30.9% in China, 25% in Norway, 48% in Germany, 46% in Denmark [23], 11% in Pakistan [24], in Turkey from 20.9 to 37.11% [15], in Qatar 20.6% and in the United Arab Emirates 20.3% [3]. In France, 1 in 4 women report urinary symptoms, the severity of which depends on age, body mass index and number of deliveries [25].
The pelvic floor consists of muscles, fascia and ligaments which are responsible for supporting the pelvic organs and maintaining their proper function. Pregnancy and childbirth can cause damage to both the structure and function of the pelvic floor [9]. Hormonal and anatomical changes are observed, relaxation of the pelvic floor muscles and subsequently their reduced contractility, and the weakening of the supporting structure of the urethra as a result of pregnancy, which increases the risk of urinary incontinence after childbirth [9]. At a hormonal level, the increased concentration of estradiol during pregnancy can adversely affect the metabolic capacity of pelvic floor muscle fibers [14].
During pregnancy and the postpartum period, most women with incontinence recover their symptoms as this is not a life-threatening condition. Urinary incontinence, if it does not subside automatically after training the pelvic floor muscles, can be combined with the appearance of accompanying problems, such as embarrassment, shame, sexual dysfunction, lack of self-esteem and social isolation, which can be particularly disturbing and lead to anxiety and depression with long-term effects on the woman’s quality of life [26]. Urinary incontinence is a major problem of psychosomatic morbidity that causes substantial damage to the quality of life [27]. The scientific community tends to search for aggravating factors. These factors are divided into modifiable and non-modifiable risk factors.
Modifiable risk factors include smoking, mode of delivery, oxytocin use and prolonged second stage of labor, pregnancy weight gain, stress and obesity [27]. A large body of literature demonstrates that obesity increases the risk of urinary incontinence, but this is not an independent risk factor. For example, waist circumference and height ratio can be a strong confounding risk factor [28]. Long-term obesity weakens the pelvic floor and the supporting structures of the urethra. It has been found that every five-unit increase in a woman’s BMI increases the potential risk of UI by 20–70% [29]. Early interventions, such as weight loss and pelvic floor muscle training, could be beneficial in reducing the incidence of urinary incontinence [30].
In the case of stress, it is observed that it can be both a risk factor in the possibility of urinary incontinence and an impact on those women who face this problem [5]. In addition, pelvic floor gynecological operations, limited physical function and especially the history of pregnancies, deliveries and perineal tears tend to be important modifiable risk factors [8,15]. Deliveries that happen with the use of suction combined with episiotomy, newborn birth weight, head circumference and gestational age may increase the risk of urinary incontinence [4,19].
Some of the non-modifiable risk factors are race, age, multiparity, fetal size and medical comorbidities such as hypertension, diabetes, history of constipation, the presence of more than 2 chronic diseases and chronic cough [27]. Also, important risk factors include gender, age of the woman over 35 years, age at menopause and ethnicity [31]. Studies have shown that pregnancy, childbirth, depression and history (first-degree relatives with urinary incontinence) influence the onset and progression of SUI [5].
Dysfunction of the autonomic nervous system and changes in the level of the neurotransmitter serotonin increase the level of catecholamines and circulating cortisol, which can cause changes in the function of the urethral sphincter and can trigger the possibility of urinary incontinence [5]. Diabetes is also associated with the occurrence of urinary incontinence, as elevated blood sugar can affect the pH of the urine, making it hypertonic and can increase episodes of urinary frequency and urgency [5].
Despite the high prevalence of urinary incontinence during pregnancy and the postpartum period, and its significant impact on women’s quality of life, the available research data remain fragmented and show significant heterogeneity in terms of incidence rates, subtypes and risk factors. Although urinary incontinence is often considered transient, a significant proportion of women experience persistent symptoms in the long term, with serious psychosocial consequences. The need for a clear evidence-based understanding of the natural course and interventions, particularly in the postpartum period, necessitates the conduct of this systematic review.

2. Aim

The aim of this systematic review was to synthesize recent evidence on postpartum urinary incontinence, focusing on its prevalence, associated risk factors and evidence-based preventive and management approaches.
More specific objectives:
To summarize the prevalence and incidence of urinary incontinence during the postpartum period.
To identify and evaluate risk factors associated with postpartum urinary incontinence based on the available evidence.
To assess the methodological quality of the included studies using a standardized appraisal approach.
To synthesize current evidence on preventive and management interventions for postpartum urinary incontinence.
To identify gaps in the literature and highlight priorities for future research.

3. Methodology

3.1. PECO Eligibility Criteria

Population (P): Postpartum women, regardless of age, parity, or mode of delivery.
Exposure (E): Potential risk factors for urinary incontinence (e.g., mode of delivery, number of pregnancies, maternal age, BMI, obstetric complications, perineal trauma, breastfeeding, hormonal changes).
Comparison (C): Postpartum women without the same risk factors or with different levels of exposure.
Outcome (O): Incidence, prevalence, severity, duration of urinary incontinence and its impact on quality of life.
Based on this framework, the formulated research question was as follows: “What are the risk factors associated with urinary incontinence during the postpartum period, and how do they influence its incidence, severity, and impact on women’s quality of life?”

3.2. Study Selection

This systematic review was based on the PRISMA method (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) and aggregated data published in international literature. A systematic bibliographic search was conducted across the electronic databases PubMed, Google Scholar and Scopus for studies concerning the relationship between risk factors and postpartum UI. Study selection was guided by predefined inclusion and exclusion criteria, as outlined below.
The review was limited to studies published within the last six years in order to reflect contemporary diagnostic criteria, assessment tools and current postpartum care practices related to urinary incontinence. The final search date was April 2025.

3.2.1. Inclusion Criteria

Women assessed for urinary incontinence within 12 months postpartum, regardless of follow-up duration.
Studies reporting any type of urinary incontinence during the postpartum period.
Research analyzing predictive or associated risk factors for postpartum urinary incontinence.
Original research studies (cross-sectional, cohort, case–control, or longitudinal).

3.2.2. Exclusion Criteria

Women with pre-existing urinary incontinence prior to pregnancy.
Studies not specifically reporting postpartum UI.
Studies including mixed populations without separate postpartum data.
Reviews, meta-analyses, case reports, letters, editorials, or conference abstracts.
Articles published in languages other than English.

3.3. Search Strategy

The search strategy was developed according to the PECO framework, using a combination of keywords and Boolean operators. The following terms and their variations were used:
Search String: (((postpartum women) OR (postnatal women) OR (women after childbirth)) AND ((urinary incontinence) OR (UI) OR (urine leakage))) AND ((risk factors) OR (predictive factors) OR (associated factors) OR (determinants)).
The initial search results were screened independently by two reviewers. After duplicates were removed, the remaining records were evaluated based on titles and abstracts according to the predefined inclusion criteria. Subsequently, the full texts of potentially relevant articles were assessed for eligibility. Disagreements regarding the inclusion of studies were resolved through discussion with a third reviewer to reach consensus. Only full-text articles published in English were included in the final synthesis, resulting in 36 studies selected for qualitative analysis.

3.4. Methodological Quality Assessment

The methodological quality and risk of bias of the studies were assessed using the NIH Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies and the Mixed Methods Appraisal Tool (MMAT) for studies with mixed-methods designs, to ensure appropriate appraisal across different study types. These tools were applied to each selected study, examining specific criteria such as: sample representativeness, control of confounding factors, assurance that urinary incontinence did not pre-exist the study period, the final sample size and data adequacy. Studies were rated as low risk of bias when the majority of quality assessment domains were fulfilled and no critical methodological limitations were identified. Studies were rated as moderate risk when some domains were not fulfilled, but without substantial risk of bias affecting the validity of the results. The detailed quality ratings for each study, as derived from the application of these tools, are presented in Table 1 and Table 2.
Table 1. NIH Quality assessment tool for observational cohort and cross-sectional studies.
Table 2. Summary of the quality appraisal of studies using the MMAT (Mixed Methods Appraisal Tool).

4. Results

In the present systematic review, the PRISMA method was used. Focusing on studies published in the last 6 years, a total of 484 articles were retrieved from the PubMed database, 690 from Google Scholar and 147 from Scopus. 1321 results were obtained. Then, by reviewing the titles and abstracts of the articles, 810 articles and 182 abstracts were excluded, respectively. Finally, 329 full texts were assessed for eligibility. After reading the full text, 293 articles were excluded. Finally, 36 articles were included in this review. Risk of bias assessment indicated variability in methodological quality across studies, with detailed judgements presented in Table 1 and Table 2. The search algorithm refers to Figure 1.
Figure 1. PRISMA diagram and process of articles’ selection.

4.1. Characteristics of the Included Studies

Table 3 summarizes the characteristics of the studies included in this review. The study sample in each of the articles varied from 140 to24.985 women. A total of 84.721 women were enlisted in the included studies. This systematic review included 10 cross-sectional studies [3,6,8,10,25,32,33,34,35,36], 14 prospective studies [4,6,13,16,18,21,26,27,29,31,37,38,39,41], 9 retrospective studies [7,11,12,14,17,20,40,42,43], 1 cohort study [22], 1 descriptive [15] and 1 longitudinal study [1].
Table 3. Characteristics of the included studies.

4.2. Data Collection Methods

Data on urinary incontinence were collected either through telephone interviews [10,36,38] or via self-administered questionnaires [3,6,9,11,15,18,27,32,33,39], provided to the participants. Some of the studies used ICIQ-UI SF Questionnaire [1,13,14,16,22,30,35,38,42] and two studies used PFDI-20 and ICIQ-FLUTS Questionnaire, respectively [20,21]. Three researchers, through UDI-6 and IIQ-7 questionnaires, tried to reveal the areas in the quality of life of the women that may have been influenced by the urine leakage [4,17,25,31]. Rajavuori et al. questionnaire based on the Wexner incontinence score [29].
Juraskova et al. screened for symptoms of anxiety and postpartum depression in new mothers by means of the Edinburgh Postnatal Depression Scale Questionnaire [26]. One researcher used a combined reproductive health and kidney conditions—urology questionnaire in order to cover areas such as menstrual history, pregnancy history, family history of urinary tract issues and urinary symptoms [34]. Last but not least, Liu et al. performed a clinical examination assessing the woman’s ability to contract their pelvic floor muscles using the modified Oxford grading system [7]. The assessment of predictive risk factors for urinary incontinence focused on either the intrapartum and postpartum period or the prenatal period.

4.3. Risk Factors Identified in Individual Studies

In the case of researchers who used telephone interviews, Zhong et al. focused on maternal age and women’s lack of knowledge, while the other two studies searched for confounding factors such as obesity and weight gain during pregnancy, history of pregestational SUI, age of the woman, type of delivery and pregestational diabetes. The duration of the follow-up was not more than one year postpartum [10,40,43].
In the case of self-administered questionnaires, Liu et al. revealed two risk factors, such as the mode of delivery and episiotomy [9]. Jansson et al. [18,39] and Patel et al. [27] also searched for additional factors such as maternal age, connective tissue deficiency, familial pelvic floor dysfunction and history of urinary tract infection. Alamri et al. focused on multiparity, maternal age and vaginal delivery [3] while Subki et al. measured the Body Mass Index and examined an important confounding factor, which was fecal incontinence [33].

4.4. Findings Based on Measurement Instruments

The International Consultation on Incontinence Questionnaire—Urinary Incontinence Short Form (ICIQ-UI SF) was used by 9 researchers in this review. Most of them were focused on maternal age, multiparity, family history of UI, high birth weight, BMI postpartum, vaginal delivery, especially forceps delivery [42], interdelivery interval less than 41 months [14] and episiotomy or spontaneous tears [13,16,22,35,38,42]. Diez-Itza et al. referred to the prolonged second stage of labor for more than 1 h and to the SUI during pregnancy [1]. Wang et al. assessed chronic coughing and constipation as the main risk factors for UI [30].
The Pelvic Floor Distress Inventory Questionnaire (PFDI-20) was the measurement instrument of Cheng et al., which assessed the impact that pelvic floor disorders have on quality of life in women [20]. Number of pregnancies, oxytocin use and delivery method were the main risk factors. Besides these, they mentioned three additional risk factors such as occupation, residence and educational level. ICIQ-FLUTS Questionnaire evaluated the severity and impact of female lower urinary tract symptoms on quality of life [21]. Huang et al. found that family history, perineal laceration after vaginal birth, frequent coughing and constipation were some of the risk factors that were revealed in their study. They also searched for a different risk factor, which was the consumption of coffee or tea [21].
The use of the Urinary Distress Inventory Questionnaire (UDI-6) and Incontinence Impact Questionnaire (IIQ-7) helped the researchers to estimate the quality of life in women who suffer from urine leakage [4,17,25,31]. Naorungrot et al. searched for risk factors such as diabetes mellitus, intrauterine growth restriction, stillbirth, breech presentation and multiple pregnancies [31]. Abushamma et al. referred to smoking, physical inactivity, unemployment and caffeine consumption as possible risk factors for UI [25]. Chang et al. found that maternal age, stillbirth and severe perineal lacerations were the risk factors for UI [17], while Ahlund et al. referred only to urinary leakage symptoms as a risk factor, before and during pregnancy [4].
Bonasia et al. used the National Health and Nutrition Examination Survey (NHANES), a program of the National Center for Health Statistics, to assess the health status of reproductive-age women. This was the main strength of the above study and also the assessment of urinary incontinence during the first 24 months after birth. Among the risk factors of UI were birth weight more than 4000 g and smoking [34].

4.5. Primary Risk Factors for Postpartum Urinary Incontinence

The results revealed that the primary risk factors for urinary incontinence during the postpartum period are vaginal delivery, obesity and maternal age. However, not only the above but also symptoms of UI before and during pregnancy, multiparity, the high birth weight of the newborn and the overall weight gain of the women during pregnancy are strong risk factors. The strengths of the study of Magnani et al. were the number of women who had been followed up for a period of over 12 to 24 months after birth. The main risk factor was the weight gain during pregnancy. The cases of UI were improved within the period of the 12th and 24th months after birth [32]. The influencing factors from the included studies are presented in Table 4.
Table 4. Factors influencing postpartum urinary incontinence.

4.6. Strengths and Limitations of the Included Studies

Ahlund’s study had a number of limitations that may have influenced the results, such as the fact that the study sample came only from two delivery wards of one hospital in Stockholm, and there was a lack of information regarding the women’s history before pregnancy [4]. The studies of Diez-Itza and Gabilondo were the only studies that investigated the long-term persistence of urinary incontinence from 6 months to 12 years after the first delivery. The very long follow-up was the main strength of these studies. The main limitation of the study of Diez-Itza was that it was not possible to perform a stress test in order to assess a strong risk factor, such as antenatal bladder neck mobility [1,37].
The main strength of Chang et study was the follow-up time with multiple time points, 3, 6 and 12 months after birth [41]. The study of Pang et al. had several limitations, such as the loss to follow-up of a high percentage of participants and the unmeasurement of the frequency and volume of urine leakage and its impact on the women’s quality of life [6]. Patel’s study gathered a population of white, college-educated women, which may not allow the generalization of the results to other populations [27]. The follow-up time of the included studies is presented in Table 5.
Table 5. Follow-up period.
Zhong et al. included women with a history of two deliveries, so the generalizability of the results to women with greater parity was not possible [40]. The limitation of the cross-sectional study of Abushamma et al. was that there was no BMI data for all the Palestinian women owing to the unwillingness of many women to reveal their weight for scientific reasons [25]. The strength of Ferrari’s study relied on the large amount of data collected from the beginning of pregnancy till the 12th month after birth to assess the risk factors that may lead to UI during the postpartum period [13].

4.7. Risk Prediction Models

Huang et al. developed a risk prediction model for urinary incontinence during the postpartum period. They are based on the following parameters: urinary incontinence during pregnancy, family history of urinary incontinence, consumption of caffeine, frequent cough and last but not least mode of delivery [21]. Zhang et al. created another risk-predictive model including pre-pregnancy BMI, height, delivery mode and induction method, fetal weight, stress urinary incontinence during pregnancy and perineal condition [43]. The risk predictive models facilitate early prevention and are significant achievements in this field.
The results from the studies are presented in Figure 2.
Figure 2. Schematic representation of risk factors of urinary incontinence.

5. Discussion

5.1. Sociodemographic Predictors-Body Mass Index and Obesity as Risk Factors

Sociodemographic factors identified, such as age, education, BMI and unemployment, are important factors associated with postpartum urinary incontinence. Regarding increased BMI, studies suggest that it may be associated with increased pressure on the bladder and may impair blood supply to this area [2,33]. In the study by Jia et al., vaginal delivery combined with high BMI was strongly associated with urinary incontinence during the postpartum period, while the problem was more likely to resolve in women with low BMI, in those who had delivered by cesarean section and in women who had mild symptoms of urinary incontinence [38].
The study by Pang et al. shows that proper management of conditions such as obesity and diabetes may be associated with a reduction in the frequency of urinary incontinence episodes [6]. The study by Wang et al. confirms that obesity and BMI are associated with an increased risk of urinary incontinence one year postpartum [49]. Control of weight gain appears important and pregnant women should be informed about the recommended weight gain during pregnancy.

5.2. Mode of Delivery and Obstetric Interventions

In Siahkal’s study et al., spontaneous vaginal delivery, invasive vaginal delivery and episiotomy were associated with a higher likelihood of urinary incontinence [19]. Meta-analysis by Wang et al. showed that maternal BMI, pregnancy and vaginal delivery were associated with postpartum UI, particularly SUI, while cesarean section appeared to be associated with a lower likelihood of UI. Regarding vaginal delivery, the use of forceps was associated with higher rates of UI, whereas vacuum extraction was not associated with an increased risk [2]. Gao et al. reported that vaginal delivery, newborn’s weight, duration of the second stage of labor, increased BMI and epidural analgesia were associated with postpartum urinary incontinence [11].

5.3. Prevalence and Characteristics of Postpartum UI

The study by Liu et al. reported that women who delivered vaginally had a higher prevalence of SUI compared to those with cesarean section, while episiotomy was associated with increased SUI rates [7]. The study by Chang et al. demonstrated that the prevalence of SUI one year after vaginal birth was 16.5%, with a significantly higher prevalence in older primiparous women (>35 years) compared to younger primiparous women [17].
Zhong et al. reported an association between prior postpartum SUI and increased likelihood of SUI in multiparous women one year postpartum [40]. The one-year follow-up period is commonly considered appropriate, as pelvic floor recovery typically occurs within this timeframe [39].

5.4. History of UI and Long-Term Predictors

The longitudinal study by Pang et al. showed that spontaneous and instrumental vaginal delivery, diabetes, middle age, chronic cough, excessive gestational weight gain and smoking were associated with SUI [6]. Novo et al. reported that age is associated with urinary incontinence, potentially due to age-related changes in urethral sphincter muscle fibers [10]. According to Dias do Rego et al., home birth was associated with a higher likelihood of stress urinary incontinence compared to hospital birth [8].
Huber et al. reported that urinary incontinence four years postpartum was more prevalent among women who experienced pelvic inflammatory symptoms during the first postpartum year [50]. Moossdorf-Steinhauser et al. found that the prevalence of urinary incontinence increased over time postpartum [44]. Management strategies should be individualized based on symptom severity [5].

5.5. Lifestyle, Exercise and Modifiable Factors

Although pelvic floor muscle function typically improves 6–10 weeks postpartum, several studies indicate that urinary incontinence may persist for up to one year [31]. Abushamma et al. reported that lack of physical exercise was associated with higher rates of urinary incontinence [25]. Yang et al. found that vaginal delivery was the factor most strongly associated with postpartum urinary incontinence [35].

5.6. Pathophysiological Mechanisms

Episiotomy has been associated with alterations in pelvic floor structures, particularly connective tissue and neuromuscular stretching [22]. Postpartum pelvic floor tissues may undergo neurological and collagen-related changes, which may contribute to pelvic floor dysfunction [11]. Dai et al. reported that lateral episiotomy was associated with more severe symptoms of stress urinary incontinence [51].

5.7. Protective Factors

Ferrari et al. identified low body weight and cesarean section as factors associated with lower rates of UI [13]. Pizzoferrato et al. reported that cesarean section was associated with lower urethral mobility and reduced urinary symptoms [45]. However, cesarean section remains controversial, as vaginal delivery also confers maternal and neonatal benefits [46].
Zhang et al. found that epidural analgesia was associated with higher rates of postpartum SUI, possibly due to prolonged labor duration [43]. Liu et al. reported that multiparity was associated with a higher likelihood of postpartum SUI [9]. Urethral hypermobility has been linked to mechanical strain during pregnancy and vaginal delivery [39].
Patel et al. reported that previous urinary incontinence and vaginal delivery were strongly associated with postpartum UI [27]. Similarly, Wang et al. identified urinary incontinence during pregnancy, delivery mode, maternal age and gestational age as key prognostic factors associated with postpartum UI [30]. Xu et al. reported that a longer inter-delivery interval was associated with lower rates of postpartum urinary incontinence [14].

5.8. Socioeconomic and Psychosocial Influences

Financial difficulties, psychosocial stress and reduced social support were associated with increased urinary incontinence symptoms [13,52]. Chang et al. reported that full-time employment was associated with postpartum urinary incontinence [16]. Abushamma et al. confirmed similar findings [25].
Xue et al. identified genetic, lifestyle and socioeconomic factors associated with urinary incontinence [23].

5.9. Endocrinological, Biological and Quality-of-Life Factors

Hormonal changes during pregnancy may influence the development of SUI [53,54]. Genetic and microbiome alterations have been associated with urinary incontinence [21,55]. Juraskova et al. reported an association between urinary incontinence and depression [3,26].

6. Strengths and Limitations

This systematic review synthesizes recent evidence on postpartum urinary incontinence using a structured and transparent methodology in accordance with PRISMA guidelines. The inclusion of multiple study designs and a broad range of risk factors provides a comprehensive perspective on postpartum urinary incontinence as a multifactorial condition, while dual independent screening enhanced the robustness of study selection.
Nevertheless, heterogeneity across studies in outcome measures, assessment tools, definitions of key variables and timing of postpartum assessment should be acknowledged. Due to heterogeneity in outcome measures and assessment tools, results were synthesized narratively rather than quantitatively, and findings should therefore be interpreted with caution. Residual confounding cannot be excluded, as most included studies were observational and adjustment for all potential confounders was not uniformly possible. Limitations of the review process should also be considered, including restriction to English-language publications, selection of specific electronic databases and the potential for publication bias. The absence of protocol may further affect transparency.

7. Conclusions

Episodes of urinary frequency and urinary incontinence may significantly affect the quality of life of a woman, her psychology, sexual life and the way she copes with daily activities, causing socio-economic costs [44,52]. The early recognition and investigation of the risk factors associated with this dysfunction could facilitate health professionals to develop prevention and treatment strategies, emphasizing the change in obstetric care, improving the prognosis and reducing the adverse effects that these could have on a woman’s quality of life [22]. The strategy of developing prognostic models in the coming years may be the only way for the early identification and follow-up of women at high risk for urinary disorders.
Detection of the type of urinary incontinence by healthcare professionals, lifestyle modifications, monitoring women’s body weight and encouraging them to follow a program of pelvic floor muscle exercises should be a priority for professionals [41]. Strengthening the knowledge of healthcare professionals is necessary to provide targeted intervention to patients when deemed necessary. At the same time, the strengthening of awareness and the understanding of dysfunctions by the women themselves could significantly reduce long-term morbidity. Women have a right to know the possible dysfunctions they may experience from their pelvic floor, as this would allow them to control some of the modifiable risk factors that can be avoided.

Author Contributions

Conceptualisation, N.T.; methodology, N.T., G.K. and A.B.; investigation, N.T., A.B. and K.G.; resources, N.T., G.K., K.G. and A.D.; data curation, N.T., K.G. and A.L.; writing-original draft preparation, N.T. and A.L.; writing-review and editing, N.T. and G.K.; visualization, N.T. and A.D.; supervision, G.K. All authors have read and agreed to the published version of the manuscript.

Funding

Special Account Grants of the University of West Attica partially financially supported the publication of the article in OA mode.

Institutional Review Board Statement

Not applicable.

Data Availability Statement

No new data were created or analyzed in this study.

Acknowledgments

AI-assisted tools were used in the drafting of this manuscript, such as language translation, language editing and grammar.

Conflicts of Interest

The authors declare no conflicts of interest.

References

  1. Diez-Itza, I.; Zubikarai, M.; Galan, C.; Ginto, L.; Saro, J.; Arrue, M. Factors involved in the persistence of stress urinary incontinence from postpartum to 12 years after first delivery. Neurourol. Urodyn. 2020, 39, 1849–1855. [Google Scholar] [CrossRef] [Scilit] [PubMed]
  2. Wang, K.; Xu, X.; Jia, G.; Jiang, H. Risk factors for postpartum stress urinary incontinence: A systematic review and meta-analysis. Reprod. Sci. 2020, 27, 2129–2145. [Google Scholar] [CrossRef] [Scilit] [PubMed]
  3. Alamri, A.; Alqahtani, M.; Asiri, K.; Albagami, S.; Hassan, B.A.; Alhumaid, R.M.; Alharbi, A.; Safar, O.; Khan, M.A. Prevalence and Risk Factors of Postpartum Urinary Incontinence in Southern Saudi Arabia: A cross-sectional study. King Khalid Univ. J. Health Sci. 2024, 9, 24–28. [Google Scholar] [CrossRef] [Scilit]
  4. Åhlund, S.; Rothstein, E.; Rådestad, I.; Zwedberg, S.; Lindgren, H. Urinary incontinence after uncomplicated spontaneous vaginal birth in primiparous women during the first year after birth. Int. Urogynecol. J. 2020, 31, 1409–1416. [Google Scholar] [CrossRef] [Scilit] [PubMed] [PubMed Central]
  5. Li, Q.; Cheng, Y.; Shi, H.; Xue, K.; Zhou, F. Advances in the natural history of urinary incontinence in adult females. J. Obstet. Gynaecol. 2023, 43, 2171774. [Google Scholar] [CrossRef] [Scilit] [PubMed]
  6. Pang, H.; Lv, J.; Xu, T.; Li, Z.; Gong, J.; Liu, Q.; Wang, Y.; Wang, J.; Xia, Z.; Li, L.; et al. Incidence and risk factors of female urinary incontinence: A 4-year longitudinal study among 24985 adult women in China. BJOG Int. J. Obstet. Gynaecol. 2021, 129, 580–589. [Google Scholar] [CrossRef] [Scilit] [PubMed] [PubMed Central]
  7. Liu, X.; Wang, Q.; Chen, Y.; Luo, J.; Wan, Y. Factors associated with stress urinary incontinence and diastasis of rectus abdominis in women at 6–8 weeks postpartum. Urogynecology 2023, 29, 844–850. [Google Scholar] [CrossRef] [Scilit] [PubMed] [PubMed Central]
  8. do Rêgo, A.D.; Peterson, T.V.; Bernardo, W.M.; Baracat, E.C.; Haddad, J.M. Comparison of stress urinary incontinence between urban women and women of indigenous origin in the Brazilian Amazon. Int. Urogynecol. J. 2021, 32, 395–402. [Google Scholar] [CrossRef] [Scilit] [PubMed]
  9. Liu, W.; Qian, L. Risk factors for postpartum stress urinary incontinence: A prospective study. BMC Urol. 2024, 24, 42. [Google Scholar] [CrossRef] [Scilit] [PubMed] [PubMed Central]
  10. Novo, R.; Perez-Rios, M.; Santiago-Pérez, M.I.; Butler, H.; Malvar, A.; Hervada, X. Prevalence and associated risk factors of urinary incontinence and dyspareunia during pregnancy and after delivery. Eur. J. Obstet. Gynecol. Reprod. Biol. 2020, 245, 45–50. [Google Scholar] [CrossRef] [Scilit] [PubMed]
  11. Gao, J.; Liu, X.; Zuo, Y.; Li, X. Risk factors of postpartum stress urinary incontinence in primiparas. What we should care. Medicine 2021, 100, e25796. [Google Scholar] [CrossRef] [Scilit] [PubMed] [PubMed Central]
  12. Wang, L.; Zhang, M.; Sha, K.; Qiao, Y.; Dong, Q. Prediction models for postpartum stress urinary incontinence: A systematic review. Heliyon 2024, 10, e37988. [Google Scholar] [CrossRef] [Scilit] [PubMed] [PubMed Central]
  13. Ferrari, A.; Mannella, P.; Caputo, A.; Simoncini, T.; Bonciani, M. Risk and protective factors for pregnancy-related urinary incontinence until 1 year postpartum: A cohort study using patient-reported outcome measures in Italy. Int. J. Gynecol. Obstet. 2024, 164, 200–209. [Google Scholar] [CrossRef] [Scilit] [PubMed]
  14. Xu, C.; Chi, X.; Guo, Y.; Chen, Y.; Chen, X. The association between the interdelivery interval and early postpartum urinary incontinence in women who had consecutive vaginal deliveries: A retrospective cohort study. Ann. Transl. Med. 2023, 11, 208. [Google Scholar] [CrossRef] [Scilit] [PubMed] [PubMed Central]
  15. Baykus, N.; Yenal, K. Prevalence of urinary incontinence in women aged 18 and over and affecting factors. J. Women Aging 2020, 32, 578–590. [Google Scholar] [CrossRef] [Scilit] [PubMed]
  16. Chang, S.-R.; Lin, W.-A.; Lin, H.-H.; Lee, C.-N.; Chang, T.-C.; Lin, M.-I. Cumulative incidence of urinary incontinence and associated factors during pregnancy and after childbirth: A cohort study. Int. Urogynecol. J. 2022, 33, 1451–1461. [Google Scholar] [CrossRef] [Scilit]
  17. Chang, S.-D.; Hsieh, W.-C.; Chiu, S.Y.-H.; Ng, K.-L.; Liang, C.-C. Factors determining the persistence of prenatal stress urinary incontinence 12 months postpartum. Taiwan. J. Obstet. Gynecol. 2023, 62, 40–44. [Google Scholar] [CrossRef] [Scilit]
  18. Jansson, M.; Franzén, K.; Tegerstedt, G.; Hiyoshi, A.; Nilsson, K. Postpartum urinary incontinence-types, prevalence, and risk factors before, during, and after pregnancy and childbirth: A prospective cohort study. Authorea 2024. [Google Scholar] [CrossRef] [Scilit]
  19. Siahkal, S.F.; Iravani, M.; Mohaghegh, Z.; Sharifipour, F.; Zahedian, M. Maternal, obstetrical and neonatal risk factors’ impact on female urinary incontinence: A systematic review. Int. Urogynecol. J. 2020, 31, 2205–2224. [Google Scholar] [CrossRef] [Scilit] [PubMed]
  20. Cheng, H.; Gong, F.; Shen, Y.; OuYang, P.; Ni, R.; Gao, H. A nomogram model predicting the risk of postpartum stress urinary incontinence in primiparas: A multicenter study. Taiwan. J. Obstet. Gynecol. 2022, 61, 580–584. [Google Scholar] [CrossRef] [Scilit] [PubMed]
  21. Huang, X.; Qin, H.; Kong, L.; Xia, H.; Lan, L.; Long, J. Development and validation of a risk prediction model for postpartum urinary incontinence in primiparas with singleton pregnancies: A multicenter clinical investigation. Front. Med. 2024, 11, 1453029. [Google Scholar] [CrossRef] [Scilit] [PubMed] [PubMed Central]
  22. Babini, D.; Lemos, A. Risk factors for urinary incontinence in primiparous adolescents after vaginal delivery: A cohort study. J. Pediatr. Adolesc. Gynecol. 2020, 33, 500–505. [Google Scholar] [CrossRef] [Scilit] [PubMed]
  23. Xue, K.; Palmer, M.H.; Zhou, F. Prevalence and associated factors of urinary incontinence in women living in China: A literature review. BMC Urol. 2020, 20, 159. [Google Scholar] [CrossRef] [Scilit] [PubMed] [PubMed Central]
  24. Abrar, S.; Rizvi, R.; Samad, A. Female urinary incontinence: Frequency, risk factors, and impact on thw quality of life of pregnant Pakistani women. Pak. J. Med. Sci. 2023, 39, 667–671. [Google Scholar] [CrossRef] [Scilit] [PubMed] [PubMed Central]
  25. Abushamma, F.; Mansour, A.; Nassar, R.; Badran, H.; Abu Alwafa, R.; Ktaifan, M.; Zyoud, S.H. Prevalence, risk factors, and impact on Quality of Life due to urinary incontinence among Palestinian Women: A cross-sectional study. Cureus 2024, 16, E57813. [Google Scholar] [CrossRef] [Scilit] [PubMed] [PubMed Central]
  26. Jurášková, M.; Piler, P.; Kukla, L.; Švancara, J.; Daňsová, P.; Hruban, L.; Kandrnal, V.; Pikhart, H. Association between stress urinary incontinence and depressive symptoms after birth: The Czech ELSPAC Study. Sci. Rep. 2020, 10, 6233. [Google Scholar] [CrossRef] [Scilit] [PubMed] [PubMed Central]
  27. Patel, K.; Long, J.B.; Boyd, S.S.; Kjerulff, K.H. Natural history of urinary incontinence from first childbirth to 30-months postpartum. Arch. Gynecol. Obstet. 2021, 304, 713–724. [Google Scholar] [CrossRef] [Scilit] [PubMed]
  28. Nygaard, I.E.; Bardsley, T.; Sheng, X.; Murtaugh, M.A.P.; Shaw, J.M. Habitus and pelvic floor symptoms and support 1 year postpartum. Obstet. Gynecol. 2021, 137, 821–830. [Google Scholar] [CrossRef] [Scilit] [PubMed] [PubMed Central]
  29. Rajavuori, A.; Repo, J.P.; Häkkinen, A.; Palonen, P.; Multanen, J.; Aukee, P. Maternal risk factors of urinary incontinence during pregnancy and postpartum: A prospective cohort study. Eur. J. Obstet. Gynecol. Reprod. Biol. X 2021, 13, 100138. [Google Scholar] [CrossRef] [Scilit] [PubMed] [PubMed Central]
  30. Wang, Q.; Jiang, X.-X.; Que, Y.Z.; Wan, X.-Y.; Lin, C.-Q. Development and validation of a risk prediction model for female stress urinary incontinence in Rural Fujian, China. Risk Manag. Healthc. Policy 2024, 17, 1101–1112. [Google Scholar] [CrossRef] [Scilit]
  31. Naorungrot, J.; Sangnucktham, T. Incidence of urinary incontinence during the postpartum period in Rajavithi hospital: A prospective cohort study. Int. Urogynecol. J. 2024, 35, 1621–1626. [Google Scholar] [CrossRef] [Scilit] [PubMed]
  32. Magnani, P.S.; Bettiol, H.; da Silva, A.A.M.; Barbieri, M.A.; Cavalli, R.d.C.; Brito, L.G.O. Urinary incontinence between 12 and 24 months postpartum: A cross-sectional study nested in a Brazilian cohort from two cities with different socioeconomic characteristics. Int. Urogynecol. J. 2019, 30, 1003–1011. [Google Scholar] [CrossRef] [Scilit] [PubMed]
  33. Subki, A.; Fakeeh, M.; Hindi, M.; Nasr, A.; Almaymuni, A.; Abduljabbar, H. Fecal and urinary incontinence associated with pregnancy and childbirth. Mater. Socio-Medica 2019, 31, 202–206. [Google Scholar] [CrossRef] [Scilit] [PubMed] [PubMed Central]
  34. Bonasia, K.; Clancy, A.; Stairs, J. Prevalence and risk factors for urinary incontinence up to 2 years postpartum: A cross-sectional population-based study. Int. Urogynecol. J. 2023, 34, 2467–2472. [Google Scholar] [CrossRef] [Scilit] [PubMed]
  35. Yang, X.; Sayer, L.; Bassett, S.; Woodward, S. The prevalence, associated factors, and impact of urinary incontinence in pregnant and postpartum women in Nanjing, China: A cross-sectional study. Asian J. Urol. 2023, 10, 337–343. [Google Scholar] [CrossRef] [Scilit] [PubMed] [PubMed Central]
  36. Okesina, B.; Fehintola, A.; Raji, H.; Abdur-Rahim, F.; Ajiboye, A.; Ayegbusi, O. Prevalence, pattern, and risk factors for urinary incontinence among women in a low-resource setting. Sanamed 2024, 19, 281–288. [Google Scholar] [CrossRef] [Scilit]
  37. Gabilondo, M.A.; Ginto, L.; Zubikarai, M.; Galán, C.; Saro, J.; Diez-Itza, I. Risk factors associated with stress urinary incontinence 12 years after first delivery. Int. Urogynecol. J. 2021, 32, 3061–3067. [Google Scholar] [CrossRef] [Scilit] [PubMed]
  38. Jia, G.; Jiang, C.; Wang, K.; Zhu, L.; Zhu, K.; Yang, S.; Jiang, H. Epidemiological investigation of urinary incontinence in peri- and postpartum women from Nanjing, China. Low. Urin. Tract Symptoms 2021, 13, 481–489. [Google Scholar] [CrossRef] [Scilit] [PubMed]
  39. Jansson, M.H.; Franzén, K.; Tegerstedt, G.; Hiyoshi, A.; Nilsson, K. Stress and urgency urinary incontinence one year after a first birth—Prevalence and risk factors. A prospective cohort study. Acta Obstet. Gynecol. Scand. 2021, 100, 2193–2201. [Google Scholar] [CrossRef] [Scilit] [PubMed]
  40. Zhong, R.; Zeng, L.; Wang, X.; Wang, Y. A retrospective study of risk factors for stress urinary incontinence 1 year after delivery in multiparous women. Int. Urogynecol. J. 2022, 33, 2275–2281. [Google Scholar] [CrossRef] [Scilit]
  41. Chang, S.-R.; Lin, W.-A.; Chang, T.-C.; Lin, H.-H.; Lee, C.-N.; Lin, M.-I. Risk factors for stress and urge urinary incontinence during pregnancy and the first year postpartum: A prospective longitudinal study. Int. Urogynecol. J. 2021, 32, 2455–2464. [Google Scholar] [CrossRef] [Scilit] [PubMed]
  42. Xu, C.; Guo, Y.; Chi, X.; Chen, Y.; Chu, L.; Chen, X. Establishment and validation of a simple nomogram for predicting early postpartum stress urinary incontinence among women with vaginal delivery: A retrospective study. BMC Women’s Health 2023, 23, 8. [Google Scholar] [CrossRef] [Scilit] [PubMed] [PubMed Central]
  43. Zhang, D.; Zhou, M.; Zhang, M.; Zhang, Y.; Wu, D.; Weng, R.; Tang, M.; Munemo, Z.P.R.; Zhang, H. Development and external validation of clinical predictive model for stress urinary incontinence in Chinese women: A multicenter retrospective study. BMC Women’s Health 2024, 24, 532. [Google Scholar] [CrossRef] [Scilit] [PubMed] [PubMed Central]
  44. Moossdorf-Steinhauser, H.; Berghmans, B.C.; Spaanderman, M.E.; Bols, E.M. Prevalence, incidence and bothersomeness of urinary incontinence between 6 weeks and 1 year post-partum: A systematic review and meta-analysis. Int. Urogynecol. J. 2021, 32, 1675–1693. [Google Scholar] [CrossRef] [Scilit] [PubMed] [PubMed Central]
  45. Pizzoferrato, A.; Briant, A.; Le Grand, C.; Gaichies, L.; Fauvet, R.; Fauconnier, A.; Fritel, X. Influence of prenatal urinary incontinence and mode of delivery in postnatal urinary incontinence: A systematic review and meta-analysis. J. Gynecol. Obstet. Hum. Reprod. 2023, 52, 102536. [Google Scholar] [CrossRef] [Scilit] [PubMed]
  46. Koomson, G.; Mgolozeli-Mgolose, S.; Mshunqane, N. Prevalence of urinary incontinence in postpartum women and physiotherapy interventions applied: An integrative review. Int. J. Gynecol. Obstet. 2024, 168, 965–977. [Google Scholar] [CrossRef] [Scilit] [PubMed] [PubMed Central]
  47. Li, J.; Zhao, X.; Li, J.; Liu, Y.; Li, T. Knowledge of urinary incontinence among women 6 weeks to 1 year after delivery. Neurourol. Urodyn. 2024, 43, 1655–1664. [Google Scholar] [CrossRef] [Scilit]
  48. Torgbenu, E.; Aimakhu, C.O.; Morhe, E.K.; Ameyaw, E.K. Prevalence and risk factors of urinary incontinence among women in Africa: A systematic review and meta-analysis. Res. Sq. 2023. [Google Scholar] [CrossRef] [Scilit]
  49. Wang, X.; Wang, H.; Xu, P.; Mao, M.; Feng, S. Epidemiological trends and risk factors related to lower urinary tract symptoms around childbirth: One-year prospective study. BMC Public Health 2023, 23, 2134. [Google Scholar] [CrossRef] [Scilit]
  50. Huber, M.; Malers, E.; Tunon, K. Pelvic floor dysfunction one year after first childbirth in relation to perineal tear severity. Sci. Rep. 2021, 11, 12560. [Google Scholar] [CrossRef] [Scilit] [PubMed] [PubMed Central]
  51. Dai, S.; Chen, H.; Luo, T. Prevalence and factors of urinary incontinence among postpartum: Systematic review and meta-analysis. BMC Pregnancy Childbirth 2023, 23, 761. [Google Scholar] [CrossRef] [Scilit] [PubMed] [PubMed Central]
  52. Saeed, A.; Qadree, M.S.; Rasool, A.G.; Shah, S.N.A.; Chaudhary, M.; Hanif, S. Association of Quality of Life and Severity of Urinary Incontinence Among Post-Partum Females: A Cross-Sectional Study. Heal. J. Physiother. Rehabil. Sci. 2023, 3, 862–870. [Google Scholar] [CrossRef] [Scilit]
  53. Dong, S.M.; Hickman, L.C. Current opinion: Postpartum urinary disorders. Curr. Opin. Obstet. Gynecol. 2023, 35, 510–516. [Google Scholar] [CrossRef] [Scilit] [PubMed]
  54. Jung, H.; Hwang, D.W.; Chun, K.-C.; Kim, Y.A.; Koh, J.W.; Han, J.Y.; Jung, H.D.; Hong, D.S.; Yun, J.S. Prevalence and risk factors of urinary incontinence in pregnant Korean women. Obstet. Gynecol. Sci. 2024, 67, 481–488. [Google Scholar] [CrossRef] [Scilit] [PubMed] [PubMed Central]
  55. Graziottin, A.; Di Simone, N.; Guarano, A. Postpartum care: Clinical considerations for improving genital and sexual health. Eur. J. Obstet. Gynecol. Reprod. Biol. 2024, 296, 250–257. [Google Scholar] [CrossRef] [Scilit] [PubMed]
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.

Article Metrics

Citations

Article Access Statistics

Multiple requests from the same IP address are counted as one view.