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Biomolecules, Volume 13, Issue 2
2023 February - 213 articles
Cover Story: Proper immune development creates a basis for a resilient immune system, which balances immune tolerance and activation, while driving away from the type 2 phenotype and thus lowering allergy risk. Human milk oligosaccharides (HMOS) possess immunomodulatory properties essential for neonatal immune development. The immunomodulatory effects of enzymatic and bacterial produced HMOS, 2’FL and 3FL, were studied in a coculture model combining the crosstalk between human intestinal epithelial cells and immune cells, which is critical in mucosal immune development. Although structurally similar, both 2’FL and 3FL differentially promote secretion of regulatory mediators from the epithelium and/or strengthen the balance of Th1 and regulatory immune responses over Th2, which was affected by the HMOS’ origin. View this paper
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