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Biomolecules
Volume 13
Issue 2
10.3390/biom13020214
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Systematic Review

Circular RNAs in Ischemic Stroke: Biological Role and Experimental Models

by
Chiara Siracusa
1,
Jolanda Sabatino
2,
Isabella Leo
1,3,
Ceren Eyileten
4,5,
Marek Postuła
4 and
Salvatore De Rosa
1,*
1
Department of Medical and Surgical Sciences, Magna Graecia University, 88100 Catanzaro, Italy
2
Department of Children and Woman’s Health, University of Padua, 35121 Padua, Italy
3
Department of Cardiology, Royal Brompton and Harefield Hospitals, Guy’s and St Thomas’ NHS Foundation Trust, London SW3 5NP, UK
4
Center for Preclinical Research and Technology CEPT, Department of Experimental and Clinical Pharmacology, Medical University of Warsaw, 02-097 Warsaw, Poland
5
Genomics Core Facility, Center of New Technologies, University of Warsaw, 02-097 Warsaw, Poland
*
Author to whom correspondence should be addressed.
Biomolecules 2023, 13(2), 214; https://doi.org/10.3390/biom13020214
Submission received: 19 December 2022 / Revised: 13 January 2023 / Accepted: 19 January 2023 / Published: 22 January 2023
(This article belongs to the Special Issue Molecular Mechanisms and Pharmacological Target of Neuroprotection)
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Abstract

Ischemic stroke is among the leading causes of morbidity, disability, and mortality worldwide. Despite the recent progress in the management of acute ischemic stroke, timely intervention still represents a challenge. Hence, strategies to counteract ischemic brain injury during and around the acute event are still lacking, also due to the limited knowledge of the underlying mechanisms. Despite the increasing understanding of the complex pathophysiology underlying ischemic brain injury, some relevant pieces of information are still required, particularly regarding the fine modulation of biological processes. In this context, there is emerging evidence that the modulation of circular RNAs, a class of highly conserved non-coding RNA with a closed-loop structure, are involved in pathophysiological processes behind ischemic stroke, unveiling a number of potential therapeutic targets and possible clinical biomarkers. This paper aims to provide a comprehensive overview of experimental studies on the role of circular RNAs in ischemic stroke.
Keywords: stroke; circular RNAs; non-coding RNAs; ischemia stroke; circular RNAs; non-coding RNAs; ischemia

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MDPI and ACS Style

Siracusa, C.; Sabatino, J.; Leo, I.; Eyileten, C.; Postuła, M.; De Rosa, S. Circular RNAs in Ischemic Stroke: Biological Role and Experimental Models. Biomolecules 2023, 13, 214. https://doi.org/10.3390/biom13020214

AMA Style

Siracusa C, Sabatino J, Leo I, Eyileten C, Postuła M, De Rosa S. Circular RNAs in Ischemic Stroke: Biological Role and Experimental Models. Biomolecules. 2023; 13(2):214. https://doi.org/10.3390/biom13020214

Chicago/Turabian Style

Siracusa, Chiara, Jolanda Sabatino, Isabella Leo, Ceren Eyileten, Marek Postuła, and Salvatore De Rosa. 2023. "Circular RNAs in Ischemic Stroke: Biological Role and Experimental Models" Biomolecules 13, no. 2: 214. https://doi.org/10.3390/biom13020214

APA Style

Siracusa, C., Sabatino, J., Leo, I., Eyileten, C., Postuła, M., & De Rosa, S. (2023). Circular RNAs in Ischemic Stroke: Biological Role and Experimental Models. Biomolecules, 13(2), 214. https://doi.org/10.3390/biom13020214

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