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Biomolecules
Volume 12
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10.3390/biom12040578
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Review

Insulin Receptors and Insulin Action in the Heart: The Effects of Left Ventricular Assist Devices

by
Konstantina Pantazi
1,
Eleni Karlafti
1,
Alexandra Bekiaridou
1,
Matthaios Didagelos
2,
Antonios Ziakas
2 and
Triantafyllos Didangelos
1,*
1
Diabetes Center, 1st Propaedeutic Department of Internal Medicine, Medical School, AHEPA University General Hospital, Aristotle University of Thessaloniki, 54621 Thessaloniki, Greece
2
First Cardiology Department, AHEPA University General Hospital, 54621 Thessaloniki, Greece
*
Author to whom correspondence should be addressed.
Biomolecules 2022, 12(4), 578; https://doi.org/10.3390/biom12040578
Submission received: 3 March 2022 / Revised: 11 April 2022 / Accepted: 12 April 2022 / Published: 14 April 2022
(This article belongs to the Special Issue 100th Anniversary of Insulin: Insulin Receptor Signaling in Health and Disease)
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Abstract

This year, 2022, marks the 100th anniversary of the isolation of human insulin and its administration to patients suffering from diabetes mellitus (DM). Insulin exerts many effects on the human body, including the cardiac tissue. The pathways implicated include the PKB/Akt signaling pathway, the Janus kinase, and the mitogen-activated protein kinase pathway and lead to normal cardiac growth, vascular smooth muscle regulation, and cardiac contractility. This review aims to summarize the existing knowledge and provide new insights on insulin pathways of cardiac tissue, along with the role of left ventricular assist devices on insulin regulation and cardiac function.
Keywords: insulin; insulin receptors; diabetes mellitus; heart; left ventricular assist device insulin; insulin receptors; diabetes mellitus; heart; left ventricular assist device

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MDPI and ACS Style

Pantazi, K.; Karlafti, E.; Bekiaridou, A.; Didagelos, M.; Ziakas, A.; Didangelos, T. Insulin Receptors and Insulin Action in the Heart: The Effects of Left Ventricular Assist Devices. Biomolecules 2022, 12, 578. https://doi.org/10.3390/biom12040578

AMA Style

Pantazi K, Karlafti E, Bekiaridou A, Didagelos M, Ziakas A, Didangelos T. Insulin Receptors and Insulin Action in the Heart: The Effects of Left Ventricular Assist Devices. Biomolecules. 2022; 12(4):578. https://doi.org/10.3390/biom12040578

Chicago/Turabian Style

Pantazi, Konstantina, Eleni Karlafti, Alexandra Bekiaridou, Matthaios Didagelos, Antonios Ziakas, and Triantafyllos Didangelos. 2022. "Insulin Receptors and Insulin Action in the Heart: The Effects of Left Ventricular Assist Devices" Biomolecules 12, no. 4: 578. https://doi.org/10.3390/biom12040578

APA Style

Pantazi, K., Karlafti, E., Bekiaridou, A., Didagelos, M., Ziakas, A., & Didangelos, T. (2022). Insulin Receptors and Insulin Action in the Heart: The Effects of Left Ventricular Assist Devices. Biomolecules, 12(4), 578. https://doi.org/10.3390/biom12040578

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