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Actin Cytoskeleton and Regulation of TGFβ Signaling: Exploring Their Links

1
Tumor Immunology and Immunotherapy Unit, IRCCS Regina Elena National Cancer Institute, via Chianesi 53, 00144 Rome, Italy
2
Institute of Biochemistry and Cell Biology, National Research Council, via Ramarini 32, 00015 Monterotondo Scalo, Rome, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this paper.
Academic Editor: Vladimir N. Uversky
Biomolecules 2021, 11(2), 336; https://doi.org/10.3390/biom11020336
Received: 19 January 2021 / Revised: 15 February 2021 / Accepted: 20 February 2021 / Published: 23 February 2021
(This article belongs to the Special Issue TGF-Beta Signaling in Tissue Fibrosis and Cancer)
Human tissues, to maintain their architecture and function, respond to injuries by activating intricate biochemical and physical mechanisms that regulates intercellular communication crucial in maintaining tissue homeostasis. Coordination of the communication occurs through the activity of different actin cytoskeletal regulators, physically connected to extracellular matrix through integrins, generating a platform of biochemical and biomechanical signaling that is deregulated in cancer. Among the major pathways, a controller of cellular functions is the cytokine transforming growth factor β (TGFβ), which remains a complex and central signaling network still to be interpreted and explained in cancer progression. Here, we discuss the link between actin dynamics and TGFβ signaling with the aim of exploring their aberrant interaction in cancer. View Full-Text
Keywords: actin cytoskeleton; actin-binding proteins; TGFβ; extracellular matrix; tumor microenvironment actin cytoskeleton; actin-binding proteins; TGFβ; extracellular matrix; tumor microenvironment
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MDPI and ACS Style

Melchionna, R.; Trono, P.; Tocci, A.; Nisticò, P. Actin Cytoskeleton and Regulation of TGFβ Signaling: Exploring Their Links. Biomolecules 2021, 11, 336. https://doi.org/10.3390/biom11020336

AMA Style

Melchionna R, Trono P, Tocci A, Nisticò P. Actin Cytoskeleton and Regulation of TGFβ Signaling: Exploring Their Links. Biomolecules. 2021; 11(2):336. https://doi.org/10.3390/biom11020336

Chicago/Turabian Style

Melchionna, Roberta; Trono, Paola; Tocci, Annalisa; Nisticò, Paola. 2021. "Actin Cytoskeleton and Regulation of TGFβ Signaling: Exploring Their Links" Biomolecules 11, no. 2: 336. https://doi.org/10.3390/biom11020336

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