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Metabolites, Volume 3, Issue 4

December 2013 - 16 articles

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Articles (16)

  • Review
  • Open Access
106 Citations
19,786 Views
15 Pages

14 October 2013

The obesity and diabetes epidemics are continuing to spread across the globe. There is increasing evidence that diabetes leads to a significantly higher risk for certain types of cancer. Both diabetes and cancer are characterized by severe metabolic...

  • Article
  • Open Access
35 Citations
8,186 Views
21 Pages

Counting and Correcting Thermodynamically Infeasible Flux Cycles in Genome-Scale Metabolic Networks

  • Daniele De Martino,
  • Fabrizio Capuani,
  • Matteo Mori,
  • Andrea De Martino and
  • Enzo Marinari

14 October 2013

Thermodynamics constrains the flow of matter in a reaction network to occur through routes along which the Gibbs energy decreases, implying that viable steady-state flux patterns should be void of closed reaction cycles. Identifying and removing cycl...

  • Article
  • Open Access
11 Citations
10,689 Views
31 Pages

Transcriptomics and Metabonomics Identify Essential Metabolic Signatures in Calorie Restriction (CR) Regulation across Multiple Mouse Strains

  • Sebastiano Collino,
  • François-Pierre J. Martin,
  • Ivan Montoliu,
  • Jamie L. Barger,
  • Laeticia Da Silva,
  • Tomas A. Prolla,
  • Richard Weindruch and
  • Sunil Kochhar

11 October 2013

Calorie restriction (CR) has long been used to study lifespan effects and oppose the development of a broad array of age-related biological and pathological changes (increase healthspan). Yet, a comprehensive comparison of the metabolic phenotype acr...

  • Article
  • Open Access
18 Citations
11,887 Views
19 Pages

11 October 2013

A simple, rapid, and inexpensive extraction method for carotenoids and other non-polar compounds present in phototrophic bacteria has been developed. The method, which has been extensively tested on the phototrophic purple non-sulphur bacterium Rhodo...

  • Article
  • Open Access
24 Citations
8,401 Views
14 Pages

Comparative Pharmacokinetics of Naringin in Rat after Oral Administration of Chaihu-Shu-Gan-San Aqueous Extract and Naringin Alone

  • Shu-Qi Li,
  • Shu Dong,
  • Zhi-Heng Su,
  • Hong-Wu Zhang,
  • Jing-Bo Peng,
  • Chang-Yuan Yu and
  • Zhong-Mei Zou

30 September 2013

Chaihu-Shu-Gan-San (CSGS), a traditional Chinese medicine (TCM) formula containing seven herbal medicines, has been used in the clinical treatment of gastritis, peptic ulcer, irritable bowel syndrome and depression in China. In order to explore the i...

  • Article
  • Open Access
26 Citations
8,362 Views
14 Pages

25 September 2013

New metabolomics applications of ultra-high resolution and accuracy mass spectrometry can provide thousands of detectable isotopologues, with the number of potentially detectable isotopologues increasing exponentially with the number of stable isotop...

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Metabolites - ISSN 2218-1989