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Sci. Pharm.
Volume 81
Issue 3
10.3797/scipharm.1212-06
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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2016). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Article

Poly-Ingredient Formulation Bresol® Ameliorates Experimental Chronic Obstructive Pulmonary Disease (COPD) in Rats

by
Mohamed RAFIQ
*,
Gollapalle Lakshminarayanashastry VISWANATHA
,
Dattatray Anturlikar SURYAKANTH
,
Mohammed AZEEMUDDIN
,
Mahalingaiah JAGADEESH
,
Krishna DHANUSH
and
Pralhad Sadashiv PATKI
Department of Pharmacology, R&D Center, The Himalaya Drug Company, Makali, Bangalore, Karnataka, India
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2013, 81(3), 833-842; https://doi.org/10.3797/scipharm.1212-06
Submission received: 6 December 2012 / Accepted: 9 May 2013 / Published: 9 May 2013
Versions Notes

Abstract

In the present study, the protective effect of Bresol® – a polyherbal formulation – was evaluated in an experimental model of cigarette smoke (CS)-induced COPD in rats. Ten minutes daily exposure to CS for 7 weeks caused significant elevation of TNF-α (p<0.01) and total protein (p<0.01) in the bronchoalveolar lavage fluid (BALF) of positive untreated control animals, indicating ongoing inflammatory process in the lungs. Further, histopathological findings have confirmed the presence of pathological lesions in the trachea and lungs. Five weeks of post-treatment with Bresol® (250 and 500 mg/kg,p.o.) showed significant and dose-dependent anti-inflammatory effects against CS-induced lung abnormalities by maintaining the TNF-α and total protein levels within the normal range. Additionally, Bresol®-treated animals showed normal cyto-architecture of the trachea and lungs. In conclusion, Bresol® showed dose-dependent protection against CS-induced lung and tracheal injury in rats, which further indicates, Bresol® is a useful healing agent, may help to decelerate the progression of COPD, and reduce the exacerbations in patients.
Keywords: Bresol®; Cigarette smoke-induced lung injury; Bronchitis; Broncheoalveolar lavage fluid; TNF-α Bresol®; Cigarette smoke-induced lung injury; Bronchitis; Broncheoalveolar lavage fluid; TNF-α

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MDPI and ACS Style

RAFIQ, M.; VISWANATHA, G.L.; SURYAKANTH, D.A.; AZEEMUDDIN, M.; JAGADEESH, M.; DHANUSH, K.; PATKI, P.S. Poly-Ingredient Formulation Bresol® Ameliorates Experimental Chronic Obstructive Pulmonary Disease (COPD) in Rats. Sci. Pharm. 2013, 81, 833-842. https://doi.org/10.3797/scipharm.1212-06

AMA Style

RAFIQ M, VISWANATHA GL, SURYAKANTH DA, AZEEMUDDIN M, JAGADEESH M, DHANUSH K, PATKI PS. Poly-Ingredient Formulation Bresol® Ameliorates Experimental Chronic Obstructive Pulmonary Disease (COPD) in Rats. Scientia Pharmaceutica. 2013; 81(3):833-842. https://doi.org/10.3797/scipharm.1212-06

Chicago/Turabian Style

RAFIQ, Mohamed, Gollapalle Lakshminarayanashastry VISWANATHA, Dattatray Anturlikar SURYAKANTH, Mohammed AZEEMUDDIN, Mahalingaiah JAGADEESH, Krishna DHANUSH, and Pralhad Sadashiv PATKI. 2013. "Poly-Ingredient Formulation Bresol® Ameliorates Experimental Chronic Obstructive Pulmonary Disease (COPD) in Rats" Scientia Pharmaceutica 81, no. 3: 833-842. https://doi.org/10.3797/scipharm.1212-06

APA Style

RAFIQ, M., VISWANATHA, G. L., SURYAKANTH, D. A., AZEEMUDDIN, M., JAGADEESH, M., DHANUSH, K., & PATKI, P. S. (2013). Poly-Ingredient Formulation Bresol® Ameliorates Experimental Chronic Obstructive Pulmonary Disease (COPD) in Rats. Scientia Pharmaceutica, 81(3), 833-842. https://doi.org/10.3797/scipharm.1212-06

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