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Sci. Pharm.
Volume 80
Issue 2
10.3797/scipharm.1107-17
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Article

Equilibrium and Release Properties of Aqueous Dispersions of Non-Steroidal Anti-Inflammatory Drugs Complexed with Polyelectrolyte Eudragit E 100

by
Daniela Alejandra QUINTEROS
,
Daniel Alberto ALLEMANDI
and
Ruben Hilario MANZO
*
Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, CP 5000, Argentina
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2012, 80(2), 487-496; https://doi.org/10.3797/scipharm.1107-17
Submission received: 13 July 2011 / Accepted: 30 April 2012 / Published: 30 April 2012
Versions Notes

Abstract

Equilibria and release properties of aqueous systems consisting of a set of five non-steroidal anti-inflammatory drugs (AH) complexed with the cationic polymethacrylate Eudragit E 100 (EU) are reported in this study. The composition (EU(AH)50 (HCl)50) having fifty mole percent of each counterion (A− and Cl−) produces clear, stable aqueous dispersions in which a remarkably high proportion of AH (higher than 98%) is condensed with the PE under the form of ion pairs. This property expands the interval of pH in which AH are aqueous soluble. The set of AH contains members with and without an alpha methyl group (-(CH3)CH-COOH: Flurbiprofen, Naproxen, Ketoprofen) and (-CH2-COOH: Diclofenac, Indomethacin). The proportion of ion pairs in the complexes was lower in the former group. Release of AH from the complexes toward a saline (NaCl 0.9%) solution was assayed in Franz cells. The five complexes behaved as drug carriers that exhibited a slow drug release with a remarkable zero order. In line with the percentages of counterionic condensation observed, release rates from -(CH3)CH-COOH complexes were clearly higher than those of -CH2-COOH ones.
Keywords: Eudragit E100®; NSAID; Complexes; Drug delivery; Aqueous Dispersions Eudragit E100®; NSAID; Complexes; Drug delivery; Aqueous Dispersions

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MDPI and ACS Style

QUINTEROS, D.A.; ALLEMANDI, D.A.; MANZO, R.H. Equilibrium and Release Properties of Aqueous Dispersions of Non-Steroidal Anti-Inflammatory Drugs Complexed with Polyelectrolyte Eudragit E 100. Sci. Pharm. 2012, 80, 487-496. https://doi.org/10.3797/scipharm.1107-17

AMA Style

QUINTEROS DA, ALLEMANDI DA, MANZO RH. Equilibrium and Release Properties of Aqueous Dispersions of Non-Steroidal Anti-Inflammatory Drugs Complexed with Polyelectrolyte Eudragit E 100. Scientia Pharmaceutica. 2012; 80(2):487-496. https://doi.org/10.3797/scipharm.1107-17

Chicago/Turabian Style

QUINTEROS, Daniela Alejandra, Daniel Alberto ALLEMANDI, and Ruben Hilario MANZO. 2012. "Equilibrium and Release Properties of Aqueous Dispersions of Non-Steroidal Anti-Inflammatory Drugs Complexed with Polyelectrolyte Eudragit E 100" Scientia Pharmaceutica 80, no. 2: 487-496. https://doi.org/10.3797/scipharm.1107-17

APA Style

QUINTEROS, D. A., ALLEMANDI, D. A., & MANZO, R. H. (2012). Equilibrium and Release Properties of Aqueous Dispersions of Non-Steroidal Anti-Inflammatory Drugs Complexed with Polyelectrolyte Eudragit E 100. Scientia Pharmaceutica, 80(2), 487-496. https://doi.org/10.3797/scipharm.1107-17

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