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Scientia Pharmaceutica is published by MDPI from Volume 84 Issue 3 (2015). Articles in this Issue were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence. Articles are hosted by MDPI on as a courtesy and upon agreement with Austrian Pharmaceutical Society (Österreichische Pharmazeutische Gesellschaft, ÖPhG).
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Sci. Pharm. 2009, 77(3), 589-596; (registering DOI)

Comparative Study on Inhibitory Activity of Zerumbone and Zerumbone 2,3-Epoxide on NF-κB Activation and NO Production

Faculty of Chemistry, College of Natural Science, Vietnam National University, Hanoi, 19 Le Thanh Tong Str., Hanoi, Vietnam
Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, Yuseong, Daejeon 305-600, Korea
Author to whom correspondence should be addressed.
Received: 23 July 2009 / Accepted: 6 August 2009 / Published: 6 August 2009
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In the present study the significant role of the α,β-unsaturated carbonyl structure in the anti-inflammatory activity of the natural humulane sesquiterpenoids zerumbone and zerumbone 2,3-epoxide was evidenced from a comparative study of the ability of zerumbone and zerumbone 2,3-epoxide to inhibit NF-κB activation and NO production in LPS (lipopolysaccharide)- stimulated RAW 264.7 cells. The IC50 of these compounds were 1.97 μM ± 0.18 and 30.11 μM ± 4.10 in the NF-κB activation assay and 3.58 μM ± 0.46 and 34.7 μM ± 3.72 in the nitric oxide production assay, respectively.
Keywords: Zerumbone; Zerumbone-2,3-epoxide; NF-κB; NO production Zerumbone; Zerumbone-2,3-epoxide; NF-κB; NO production
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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GIANG, P.M.; SON, P.T.; JIN, H.Z.; LEE, J.H.; LEE, J.J. Comparative Study on Inhibitory Activity of Zerumbone and Zerumbone 2,3-Epoxide on NF-κB Activation and NO Production. Sci. Pharm. 2009, 77, 589-596.

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