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Volume 77
Issue 3
10.3797/scipharm.0907-16
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Article

Comparative Study on Inhibitory Activity of Zerumbone and Zerumbone 2,3-Epoxide on NF-κB Activation and NO Production

by
Phan M. GIANG
1,*,
Phan T. SON
1,
Hui Z. JIN
2,
Jeong H. LEE
2 and
Jung J. LEE
2
1
Faculty of Chemistry, College of Natural Science, Vietnam National University, Hanoi, 19 Le Thanh Tong Str., Hanoi, Vietnam
2
Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, Yuseong, Daejeon 305-600, Korea
*
Author to whom correspondence should be addressed.
Sci. Pharm. 2009, 77(3), 589-596; https://doi.org/10.3797/scipharm.0907-16
Submission received: 23 July 2009 / Accepted: 6 August 2009 / Published: 6 August 2009
Versions Notes

Abstract

In the present study the significant role of the α,β-unsaturated carbonyl structure in the anti-inflammatory activity of the natural humulane sesquiterpenoids zerumbone and zerumbone 2,3-epoxide was evidenced from a comparative study of the ability of zerumbone and zerumbone 2,3-epoxide to inhibit NF-κB activation and NO production in LPS (lipopolysaccharide)- stimulated RAW 264.7 cells. The IC50 of these compounds were 1.97 μM ± 0.18 and 30.11 μM ± 4.10 in the NF-κB activation assay and 3.58 μM ± 0.46 and 34.7 μM ± 3.72 in the nitric oxide production assay, respectively.
Keywords: Zerumbone; Zerumbone-2,3-epoxide; NF-κB; NO production Zerumbone; Zerumbone-2,3-epoxide; NF-κB; NO production

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MDPI and ACS Style

GIANG, P.M.; SON, P.T.; JIN, H.Z.; LEE, J.H.; LEE, J.J. Comparative Study on Inhibitory Activity of Zerumbone and Zerumbone 2,3-Epoxide on NF-κB Activation and NO Production. Sci. Pharm. 2009, 77, 589-596. https://doi.org/10.3797/scipharm.0907-16

AMA Style

GIANG PM, SON PT, JIN HZ, LEE JH, LEE JJ. Comparative Study on Inhibitory Activity of Zerumbone and Zerumbone 2,3-Epoxide on NF-κB Activation and NO Production. Scientia Pharmaceutica. 2009; 77(3):589-596. https://doi.org/10.3797/scipharm.0907-16

Chicago/Turabian Style

GIANG, Phan M., Phan T. SON, Hui Z. JIN, Jeong H. LEE, and Jung J. LEE. 2009. "Comparative Study on Inhibitory Activity of Zerumbone and Zerumbone 2,3-Epoxide on NF-κB Activation and NO Production" Scientia Pharmaceutica 77, no. 3: 589-596. https://doi.org/10.3797/scipharm.0907-16

APA Style

GIANG, P. M., SON, P. T., JIN, H. Z., LEE, J. H., & LEE, J. J. (2009). Comparative Study on Inhibitory Activity of Zerumbone and Zerumbone 2,3-Epoxide on NF-κB Activation and NO Production. Scientia Pharmaceutica, 77(3), 589-596. https://doi.org/10.3797/scipharm.0907-16

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