Table of Contents
Diseases, Volume 7, Issue 3 (September 2019) – 7 articles
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Cover Story (view full-size image) Congenital heart disease (CHD) is the most common birth defect worldwide and the number one killer [...] Read more. Congenital heart disease (CHD) is the most common birth defect worldwide and the number one killer of live-born infants in the United States. Heart development is strikingly complex and occurs early in embryogenesis, limiting the understanding and consequent treatment of CHD. Furthermore, genome sequencing has failed to explain most cases of CHD. In addition to the underlying genome, epigenetics and mechanotransduction are essential for normal heart development and have recently been implicated as playing a role in CHD pathogenesis. This review summarizes human heart development and discusses the roles of epigenetics and mechanobiology in normal development and CHD. Further research into these systems is promising for improved diagnosis and further elucidation of CHD etiology.View this paper.