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Diseases, Volume 7, Issue 3

September 2019 - 7 articles

Cover Story: Congenital heart disease (CHD) is the most common birth defect worldwide and the number one killer of live-born infants in the United States. Heart development is strikingly complex and occurs early in embryogenesis, limiting the understanding and consequent treatment of CHD. Furthermore, genome sequencing has failed to explain most cases of CHD. In addition to the underlying genome, epigenetics and mechanotransduction are essential for normal heart development and have recently been implicated as playing a role in CHD pathogenesis. This review summarizes human heart development and discusses the roles of epigenetics and mechanobiology in normal development and CHD. Further research into these systems is promising for improved diagnosis and further elucidation of CHD etiology.View this paper.
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Articles (7)

  • Article
  • Open Access
5 Citations
4,788 Views
15 Pages

11 September 2019

Background: Chronic diseases have an impact on and can change the lives of the persons affected by them. This study examines how a disease can influence patients’ daily lives, the strategies they adopt to cope, and their experiences of support....

  • Review
  • Open Access
53 Citations
10,829 Views
27 Pages

Epigenetics and Mechanobiology in Heart Development and Congenital Heart Disease

  • Dillon K. Jarrell,
  • Mallory L. Lennon and
  • Jeffrey G. Jacot

1 September 2019

Congenital heart disease (CHD) is the most common birth defect worldwide and the number one killer of live-born infants in the United States. Heart development occurs early in embryogenesis and involves complex interactions between multiple cell popu...

  • Review
  • Open Access
16 Citations
5,906 Views
10 Pages

Mechanism of Fibrosis Induced by Echinococcus spp.

  • Fuqiu Niu,
  • Shigui Chong,
  • Mingqun Qin,
  • Shenmei Li,
  • Riming Wei and
  • Yumin Zhao

12 August 2019

Infection with Echinococcus spp. causes fibrosis in various vital organs, including the liver and lungs. Hepatic fibrosis is a pathological feature of Echinococcus infection that destroys normal liver tissue, leading to jaundice, cholecystitis, porta...

  • Article
  • Open Access
17 Citations
9,126 Views
10 Pages

Background: This study sought to determine the prevalence of carotid artery calcifications (CACs) and pulp stones detected on panoramic radiographs (PRs) and ascertain their correlation. Methods: A total of 2013 digital PRs were retrospectively retri...

  • Review
  • Open Access
19 Citations
13,451 Views
9 Pages

Bipolar disorder and borderline personality disorder are among the most frequently diagnosed psychiatric conditions. However, the nosological aspects and diagnostic boundaries of both conditions have historically been the object of considerable contr...

  • Review
  • Open Access
11 Citations
6,678 Views
27 Pages

Although individually uncommon, rare diseases collectively account for a considerable proportion of disease impact worldwide. A group of rare genetic diseases called the mucopolysaccharidoses (MPSs) are characterized by accumulation of partially degr...

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Diseases - ISSN 2079-9721