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Diseases, Volume 13, Issue 7

July 2025 - 41 articles

Cover Story: Although Fanconi anemia (FA) is traditionally considered a pediatric disease characterized by short stature and an array of congenital abnormalities that prompt diagnostic consideration, the availability of next-generation sequencing is resulting in an increasing number of patients first being diagnosed as adults, many of whom lack classic physical stigmata. Similarly, while bone marrow failure is the most common presentation in children, adult patients may also present with myelodysplasia or AML. Clues to the underlying diagnosis of FA include abnormalities in chromosomes 1 and 3, marked toxicity after chemotherapy or even squamous cell cancers in the head and neck or anogenital region in young patients. Transplant is the only curative treatment but there is a lack of literature on the approach to the adult patient. View this paper
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Articles (41)

  • Article
  • Open Access
711 Views
12 Pages

Fibrin Monomer and Systemic Lupus Erythematosus Reactivation During Pregnancy: A Retrospective Study

  • Tran Thi Kieu My,
  • Hoang Thi Ha,
  • Nguyen Huu Truong,
  • Dao Thi Thiet,
  • Nguyen Khanh Ha,
  • Tran Dang Xoay,
  • Linus Olson and
  • Bach Quoc Khanh

Background: Pregnancies in patients with systemic lupus erythematosus (SLE) have always been considered high-risk. D-dimer is known for its role in excluding the diagnosis of thrombosis and has been associated with lupus reactivation; however, its ph...

  • Review
  • Open Access
1 Citations
1,920 Views
12 Pages

Descriptive Analysis of Reported Adverse Events Associated with Vitiligo Medications Using FDA Adverse Event Reporting System (FAERS) Databases 2013–2023

  • Saleh F. Alqifari,
  • Musaab Habibulla Gari,
  • Jeff J. Guo,
  • Shoroq Alamin,
  • Aya K. Esmail,
  • Abdullah K. Esmail,
  • Heba R. Hamad,
  • Ahmed Aljabri,
  • Amirah M. Alatawi and
  • Laila A. Albishi
  • + 2 authors

Vitiligo, an autoimmune disorder causing depigmented skin patches, includes two types, segmental (SV) and non-segmental (NSV). Previously, NSV was off-label treated using Calcineurine inhibitors (Tacrolimus and Pimecrolimus). In 2022, the FDA approve...

  • Review
  • Open Access
7 Citations
7,726 Views
18 Pages

Hepatocellular Carcinoma: A Comprehensive Review

  • Nisar Amin,
  • Javaria Anwar,
  • Abdullahi Sulaiman,
  • Nadia Nikolaeva Naumova and
  • Nadeem Anwar

Hepatocellular carcinoma (HCC) is the sixth most common malignancy globally and remains one of the leading causes of cancer-related mortality. Its incidence continues to rise worldwide, and it is currently the fastest-growing cancer by incidence in t...

  • Article
  • Open Access
987 Views
15 Pages

CD79A and IL7R mRNA Levels in the Cerebrospinal Fluid of Adults with Acute B-Cell Lymphoblastic Leukemia: A Pilot Study

  • Andrea Iracema Milán Salvatierra,
  • Juan Carlos Bravata Alcántara,
  • Víctor Manuel Alvarado Castro,
  • Estibeyesbo Said Plascencia Nieto,
  • Faustino Cruz Leyto,
  • Mónica Tejeda Romero,
  • Jorge Cruz Rico,
  • Bogar Pineda Terreros,
  • Sandra López Palafox and
  • Adriana Jiménez
  • + 4 authors

Background/Objectives: In adults with B-cell acute lymphoblastic leukemia (B-ALL), central nervous system (CNS) involvement represents a significant clinical challenge due to its association with adverse outcomes. Infiltration of blast cells into the...

  • Article
  • Open Access
1,313 Views
13 Pages

Salmonella Typhi-Exposed Placentae: Chorionic Villi Histomorphology and Neonatal Birthweight

  • Patience B. Tetteh-Quarcoo,
  • Joana Twasam,
  • Kevin Kofi Adutwum-Ofosu,
  • John Ahenkorah,
  • Bismarck Afedo Hottor,
  • Nicholas T. K. D. Dayie,
  • Peter Ofori Appiah,
  • Emmanuel Afutu,
  • Fleischer C. N. Kotey and
  • Emilia Asuquo Udofia
  • + 3 authors

30 June 2025

Background: Salmonella infections impose a substantial global health burden, with an estimated 95.1 million cases occurring annually. Pregnant women exhibit a heightened vulnerability due to pregnancy-specific immune adaptations and dietary habits th...

  • Case Report
  • Open Access
1,121 Views
18 Pages

Pancreatic Endometriosis Coexisting with a Splenic Mesothelial Cyst: A Rare Case Report and Review of the Literature

  • Daniel Paramythiotis,
  • Antonia Syrnioti,
  • Dimitrios Tsavdaris,
  • Aikaterini Smprini,
  • Alexandros Mekras,
  • Athanasios Apostolidis and
  • Angeliki Cheva

30 June 2025

Endometriosis is a clinical entity affecting up to 10% of women of reproductive age, characterized by ectopic endometrial tissue outside the uterine cavity. While extrapelvic endometriosis has been documented, pancreatic endometriosis remains extreme...

  • Article
  • Open Access
801 Views
12 Pages

Microsatellite Instability and BAT-26 Marker Expression in a Mexican Prostate Cancer Population with Different Gleason Scores

  • Ana K. Flores-Islas,
  • Manuel A. Rico-Méndez,
  • Marisol Godínez-Rubí,
  • Martha Arisbeth Villanueva-Pérez,
  • Erick Sierra-Díaz,
  • Ana Laura Pereira-Suárez,
  • Saul A. Beltrán-Ontiveros,
  • Perla Y. Gutiérrez-Arzapalo,
  • José M. Moreno-Ortiz and
  • Adrián Ramírez-de-Arellano

30 June 2025

Background/Objectives: Prostate cancer (PCa) is one of the most common cancers in men worldwide. While standard treatments often provide good initial results, many patients eventually develop resistance and experience a more aggressive relapse. Micro...

  • Hypothesis
  • Open Access
5,744 Views
23 Pages

30 June 2025

Background/Objectives: Chronic illness after COVID-19 vaccination (longvax) lacks a therapeutic protocol anchored in pathophysiology. Persistent vaccine derived spike protein appears to trigger microvascular fibrin amyloid microclots, immune dysfunct...

  • Case Report
  • Open Access
1,903 Views
17 Pages

Subcutaneous Panniculitis-like T-Cell Lymphoma: Diagnostic Challenge and Successful Multimodal Management with Integra® Dermal Matrix—Case Report and Review of the Literature

  • Daniel Pit,
  • Teodora Hoinoiu,
  • Bogdan Hoinoiu,
  • Simona Cerbu,
  • Maria Iordache,
  • Adrian Vaduva,
  • Diana Szilagyi,
  • Claudia Ramona Bardan,
  • Panche Taskov and
  • Zorin Petrisor Crainiceanu
  • + 2 authors

30 June 2025

Background/Objectives: Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare and aggressive cutaneous lymphoma, often misdiagnosed due to nonspecific clinical features. Early diagnosis and treatment remain challenging. Methods: We report t...

  • Article
  • Open Access
726 Views
18 Pages

Hypovitaminosis D Does Not Aggravate the Progression of Gentamicin-Induced Kidney Injury in Rats

  • Ana Lívia D. Maciel,
  • Amanda L. Deluque,
  • Beatriz M. Oliveira,
  • Cláudia S. Souza,
  • Heloísa D. C. Francescato,
  • Cleonice Giovanini,
  • Francisco J. A. de Paula,
  • Terezila M. Coimbra and
  • Rildo A. Volpini

28 June 2025

Background/Objectives: Gentamicin is one of the most effective and widely used antibiotics to treat serious infections. In addition to its bactericidal properties, gentamicin has a nephrotoxic effect that results in acute kidney injury (AKI). AKI may...

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Diseases - ISSN 2079-9721