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Diseases, Volume 13, Issue 3

March 2025 - 27 articles

Cover Story: Pseudoarthrosis, the failure of normal fracture healing, affects 10–15% of long bone fractures, causing pain, disability, and the need for repeated surgeries. Despite advances in understanding bone healing, diagnostics still rely on clinical and radiographic assessments, lacking precise predictive tools. This review explores the genetic and biological basis of pseudoarthrosis, highlighting key mechanisms such as mesenchymal stromal cell dysfunction, altered BMP signaling, and genetic polymorphisms. It emphasizes the need for future research to develop innovative diagnostics and personalized therapies. View this paper

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Review

5 Citations

10,093 Views

22 Pages

Electrolyte Imbalances and Metabolic Emergencies in Obesity: Mechanisms and Clinical Implications

Iulia Najette Crintea,
Alexandru Cristian Cindrea,
Ovidiu Alexandru Mederle,
Cosmin Iosif Trebuian and
Romulus Timar

Diseases2025, 13(3), 69;https://doi.org/10.3390/diseases13030069

24 February 2025

Electrolyte imbalances are a frequently overlooked yet critical component of obesity-related metabolic dysfunction, contributing to an increased risk of cardiovascular disease, kidney impairment, and metabolic emergencies such as diabetic ketoacidosi...

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Systematic Review

1 Citations

1,602 Views

30 Pages

SGLT2 Inhibitors in COVID-19: Umbrella Review, Meta-Analysis, and Bayesian Sensitivity Assessment

Vinay Suresh,
Muhammad Aaqib Shamim,
Victor Ghosh,
Tirth Dave,
Malavika Jayan,
Amogh Verma,
Vivek Sanker,
Priyanka Roy and
Mainak Bardhan

Diseases2025, 13(3), 67;https://doi.org/10.3390/diseases13030067

21 February 2025

Background: Several studies have reported a reduced risk of COVID-19-related mortality in patients taking antidiabetic medications. This is an umbrella review, meta-analysis, and Bayesian sensitivity assessment of SGLT2 inhibitors (SGLT2is) in COVID-...

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Article

3 Citations

1,677 Views

16 Pages

Healthcare Resource Utilization and Economic Outcomes of RSV-Hospitalized Patients Aged ≥ 60 Years: A Retrospective Cohort Study

Anna Puggina,
Melania Dovizio,
Alexander Domnich,
Alen Marijam,
Chiara Veronesi,
Caterina Rizzo,
Marta Vicentini,
Luca Degli Esposti,
Giovanna Elisa Calabrò and
Maria João Fonseca

Diseases2025, 13(3), 68;https://doi.org/10.3390/diseases13030068

21 February 2025

Background/Objectives The economic impact of respiratory syncytial virus (RSV) in Italy is not well defined. This analysis assessed the economic outcomes of RSV-hospitalized patients aged ≥ 60 years in Italy. Methods: Healthcare resource utilizati...

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Article

1 Citations

888 Views

11 Pages

Demographic, Premorbid, and Clinical Characteristics of Schizophrenia Spectrum Patients with High and Low Polygenic Liability to the Disorder

Margarita Alfimova,
Marina Gabaeva,
Tatyana Lezheiko,
Victoria Plakunova,
Yulia Chaika and
Vera Golimbet

Diseases2025, 13(3), 66;https://doi.org/10.3390/diseases13030066

21 February 2025

Background/Objectives: Schizophrenia is a clinically heterogeneous complex disorder with a substantial polygenic basis. The discovery of phenotypes indexing genetic differences advances research into the schizophrenia etiology but has proven to be ch...

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Expression of Concern

483 Views

1 Page

Expression of Concern: Gasser et al. Testosterone/Epitestosterone Ratios—Further Hints to Explain Hyperandrogenemia in Children with Autism. Diseases 2021, 9, 13

Diseases Editorial Office

Diseases2025, 13(3), 65;https://doi.org/10.3390/diseases13030065

21 February 2025

With this notice, the Diseases Editorial Office states their awareness of the concerns regarding potential scientific errors and an authorship dispute relating to this publication [...]

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Article

810 Views

10 Pages

Examination of Respiratory Disturbance Index Before and After Cheiloplasty and Palatoplasty

Ryo Murasugi,
Hitoshi Kawanabe,
Ayano Murakami,
Yasuhiko Fukuya,
Hideto Imura,
Nagato Natsume,
Ken Sato,
Seiko Mitachi and
Kazunori Fukui

Diseases2025, 13(3), 64;https://doi.org/10.3390/diseases13030064

21 February 2025

Background/Objectives: Pediatric sleep-disordered breathing (SDB) can cause behavioral and cognitive problems and even physical growth impairment, but it is often under-recognized. Cleft lip and/or palate (CLP) is a common birth defect and known risk...

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Article

1 Citations

1,375 Views

12 Pages

Is Global Limb Anatomic Staging System Classification a Useful Tool in Predicting Lower Limb Revascularization Procedures’ Success?

Andreea Luciana Rata,
Nawaf Al Khazaleh,
Sergiu Sirca,
Cătălin Alexandru Pîrvu,
Alexandru Furdui,
Elena Rizea and
Sorin Barac

Diseases2025, 13(3), 63;https://doi.org/10.3390/diseases13030063

20 February 2025

Background. GLASS (Global Limb Anatomic Staging System) classification is a classification proposed in 2019 by The Lower Extremity Guidelines Committee of the Society for Vascular Surgery, which aims to identify the anatomic substrate that defines th...

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