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Diseases, Volume 10, Issue 1

March 2022 - 17 articles

Cover Story: In a person with a high level of Lp(a), the cholesterol in this particle has the potential to contribute a significant portion of the reported LDL-C. The concentration of Lp(a) in patients with potential FH is 40–60% higher than in those with unlikely FH. The results of our study show that the use of a corrected level of LDL-C based on Lp(a) concentration for FH clinical diagnosis leads to a significant diagnosis reclassification to less severe and reduces the likelihood of true FH. The LDL-C level corrected by Lp(a)-cholesterol should be considered when making the FH diagnosis in patients with Lp(a) concentration ≥40 mg/dl. The proportion of cholesterol in Lp(a) can reach 74% of total LDL-C concentration in patients with hyperlipoproteinemia(a). View this paper
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Articles (17)

  • Review
  • Open Access
17 Citations
11,679 Views
8 Pages

Thyroglossal Duct Cyst, a Case Report and Literature Review

  • Anas Taha,
  • Bassey Enodien,
  • Daniel M. Frey and
  • Stephanie Taha-Mehlitz

25 January 2022

A thyroglossal duct cyst (TGDC) is one of the most commonly encountered congenital anomalies of the neck. However, it is difficult to diagnose as differentiating it from other cysts like brachial cysts, lymphangiomas, epidermoid cysts, dermoid cysts,...

  • Feature Paper
  • Article
  • Open Access
5 Citations
3,464 Views
8 Pages

Elevated Lipoprotein(a) Level Influences Familial Hypercholesterolemia Diagnosis

  • Uliana V. Chubykina,
  • Marat V. Ezhov,
  • Olga I. Afanasieva,
  • Elena A. Klesareva and
  • Sergei N. Pokrovsky

18 January 2022

Familial hypercholesterolemia (FH) and elevated lipoprotein(a) [Lp(a)] level are the most common inherited disorders of lipid metabolism. This study evaluated the impact of high Lp(a) level on accuracy Dutch Lipid Clinic Network (DLCN) criteria of he...

  • Article
  • Open Access
13 Citations
4,502 Views
9 Pages

Comparing Diagnosis and Treatment of Pulmonary Hypertension Patients at a Pulmonary Hypertension Center versus Community Centers

  • Hollie Saunders,
  • Scott A. Helgeson,
  • Ahmed Abdelrahim,
  • Kathleen Rottman-Pietrzak,
  • Victoria Reams,
  • Tonya K. Zeiger,
  • John E. Moss and
  • Charles D. Burger

7 January 2022

Once patients are diagnosed with pulmonary hypertension it is important to identify the correct diagnostic group as it will have implications on the disease state management. Pulmonary hypertension is increasingly diagnosed and treated in general med...

  • Article
  • Open Access
6 Citations
3,761 Views
11 Pages

Structural Analysis of SMYD3 Lysine Methyltransferase for the Development of Competitive and Specific Enzyme Inhibitors

  • Dillon K. Jarrell,
  • Kelly N. Hassell,
  • Ilham Alshiraihi,
  • Debbie C. Crans and
  • Mark A. Brown

29 December 2021

Lysine methylation is among the key posttranslational modifications to histones that contribute to epigenetic regulation. SMYD3 is a lysine methyltransferase that is essential for the proliferation of a range of tumorigenic cells. The findings that S...

  • Opinion
  • Open Access
8 Citations
4,149 Views
7 Pages

27 December 2021

Dyslipidemia is a major modifiable risk factor for ischemic stroke. Treatment with statins reduces the incidence of recurrent ischemic stroke and also reduces coronary events in patients with a history of ischemic stroke. Therefore, statins represent...

  • Article
  • Open Access
3 Citations
4,199 Views
14 Pages

24 December 2021

CKDu needs to be characterized in fundamental areas to improve etiological understanding and disease management. In a cross-sectional study, blood cell profile and plasma inflammatory cytokines were followed by automated analysis and sandwich ELISA,...

  • Article
  • Open Access
7 Citations
4,800 Views
16 Pages

Epidemiological Characteristics of Hospitalized Patients with Moderate versus Severe COVID-19 Infection: A Retrospective Cohort Single Centre Study

  • Faryal Khamis,
  • Salah Al Awaidy,
  • Muna Al Shaaibi,
  • Mubarak Al Shukeili,
  • Shabnam Chhetri,
  • Afra Al Balushi,
  • Sumaiya Al Sulaimi,
  • Amal Al Balushi and
  • Ronald Wesonga

23 December 2021

COVID-19 has a devastating impact worldwide. Recognizing factors that cause its progression is important for the utilization of appropriate resources and improving clinical outcomes. In this study, we aimed to identify the epidemiological and clinica...

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Diseases - ISSN 2079-9721