Review Reports

Reviewer 1

1.       

“Medicinal value” paid attention in the Introduction, but correlation with reviewed data later is missing.

We have added the following sentences:

        i.            Page 5, Line 139

Therefore, Vitamin E has been used in lipsticks preparations as an antioxidant

      ii.            Page 5. Line 141
Lanolin is utilised in cosmetics and topical medications because of its emollient qualities

    iii.            Page 6. Line 211
The extracts of M. indica have been reported to have antiviral, antibacterial, analgesic, anti-inflammatory, immunomodulatory, anti-amoebic, cardiotonic, and diuretic effects

2.       

“History of lipstick” should be improved and rewritten in scientific level.

The “history of lipstick” was rewritten in scientific level and the information was arranged chronologically (Page 2, Line 51 to 65)

3.       

“Ingredients of lipstick” should be expanded: separate ingredients to natural and synthetic (1 table); add information about herbal active substances used in formulations. All part is focused on laboratory scale, but industrial formulations are also.

Thanks for highlighting these points.

“Ingredients of lipstick” subtopic was expanded as suggested. Table 1 was separated into two tables. Table 1 (Synthetic ingredients) and Table 2 (Natural ingredients) respectively.  More information was added (e.g the ingredients presented  in the tables were added from eight to 42) . (Page 2 to 4)

4.       

“Method of preparation” contains one method, but differences or similarities of cited researchers is not clear. I recommend to present this part in graphical format.

This part was rewritten, and graphical format was added. (Page 8 and 9. Line 358 to 375)

5.       

“Characterization” part should be supplemented: what instrument were used in reviewed studies; what official requirements can be set as quality parameters for lipsticks.

The characterizations were amended and information on “Skin irritation test” and “Lead and other metal limit test” was added, (Page 11, Line 500 to 525)

6.       

“what instrument were used in reviewed studies?”

We added the following information:

        i.            Page 9, Line 386
“….digital melting point apparatus”

      ii.            Page 9, Line 403 to 405

            “…ring and ball method……in a water bath”

    iii.            Page 9, Line 418

           “The texture analyser was also used….”

    iv.            Page 10, Line 426

         “….used penetrometer to determine the thixotrophy properties of the lipstick”

      v.            Page 11, Line 493

           “…using pH meter…”

7.       

What official requirements can be set as quality parameters for lipsticks?

We added the following sentences.

        i.            Page 10, Line 430

Based on the reviewed data, there is no single study mentioned the comparison of the thixo-trophic results to the reference guidelines. This could suggest that no guidelines for this test have been developed.

      ii.            Page 10, Line 438

This test was described in the reviewed data and the results were based on the authors experience and comparison with other published data. To our knowledge, there is no specific guidelines for this test to be followed or used as standard reference.

    iii.            Page 10, Line 467

The accelerated stability studies were carried out as per the ICH guidelines by storing at 40 ºC/75% relative humidity

8.       

Please improve the conclusion chapter.

We have edited the conclusion as suggested by the reviewer (Page 11, Line 528)

Reviewer 2

The article is well structured and didactic, the subject is very interesting, but the information is presented in a very superficial way. I understand that it may be a little explored topic in the scientific literature, but the type of article - review, has a lower content than other examples in the same journal.

Thanks for the comments and suggested improvements. The article was rewritten, and more detailed information was provided

I recommend that the topic be described in more depth, for example on the pharmacological properties that can be incorporated into lipstick.

We have added the following sentences:

        i.            Page 4, Line 91
“A four-week study…”

      ii.            Page 4, Line 116
“However, Lipstick dermatitis caused by….”

    iii.            Page 4, Line 132
“Moreover, lipstick may….”

    iv.            Page 5, Line 150
“Nonetheless, despite the benefits, after repeating or prolonged…..”

      v.            Page 6, Line 208
“Mango butter, also known as Amra…”

    vi.            Page 6, Line 232
“Lycopene is a naturally occurring carotenoid……”

  vii.            Page 6, Line 238
“Due to its potential biological applications…..”

viii.            Page 6, Line 252
Much of the current literature on ginger pays particular attention to isolating and analysing pharmacologically a variety of bioactive compounds such as tannins, flavonoids, glycosides, essential oils, furostanol, spirostanol, saponins, phytosterols, amides, and alkaloids from different parts of the plants

    ix.            Page 7, Line 262

“Curcuma longa (turmeric) was utilized….”

      x.            Page 7, Line 287
“The phenolics include……”

    xi.            Page 8, Line 340

“Cholesterol lowering, reduced risk of cardiovascular….”

  xii.            Page 8, Line 345

“It has the hue of the pulpy exocarp…”

xiii.            Page 8, Line 347
“As Pitaya contains a substantial amount of linoleic and linolenic acids….”

Reviewer 3

1.       

Line 15; should be written either to date or to our knowledge.

Line 15 was changed “to date” and “to our knowledge was removed”.

2.       

Line 50-51; should be rewritten.

Line 50-51 was rewritten, please check the line number (47-49) which highlighted in yellow colour in the new attached manuscript.

3.       

Table 1, please separate references by a comma.

The references were separated by a comma

4.       

Line 82; please write the full name of the castor oil.

The full name of the castor oil was added (Line 301)