“Micro-Nanofabricated Sensors for Bioanalysis” represents a cutting-edge field in biosensing technology which leverages the integration of micro- and nanoscale fabrication techniques. These advancements aim to develop highly sensitive, miniaturized sensors tailored for biological analysis across a variety of samples. These sensors are specifically designed to detect and analyze biomolecules, such as proteins and neurotransmitters, and various biological samples, including single cells, brain tissue, and subcellular organelles, with high precision and sensitivity.
Current research in this field focuses on leveraging micro- and nanofabrication methods, such as photolithography, nanoimprinting, and microfluidics, to create sensor platforms with enhanced capabilities. These sensors commonly utilize various transduction mechanisms—using electrochemical, optical, or mechanical principles—to convert biological interactions into measurable signals. This enables the detection of biomarkers, enzymes, DNA sequences, proteins, and other analytes critical for medical diagnostics, environmental monitoring, and biotechnological applications.
In recent decades, integrating sensors with nanostructures has shown the potential to improve their capabilities and signal-to-noise ratio. Various nanostructures, including nanoparticles, nanotubes, nanowires, and nanocomposites, effectively enhance sensor performance and productivity. Developing new nanostructures promises the ability to further enhance sensor performance in the near future. The emergence of point-of-care devices and wearable biosensors is expected to revolutionize healthcare by enabling real-time monitoring and personalized clinical diagnostic applications.
Continuous innovation in fabrication techniques, material science, and signal processing, combined with interdisciplinary collaborations, will propel the evolution of micro-nanofabricated sensors. These advancements will lead to breakthroughs in bioanalysis and carry profound implications across various domains. Due to these significant advantages and their importance, this Special Issue is dedicated to collecting and presenting recent advances in a range of topics related to Micro-Nanofabricated Sensors for Bioanalysis.
Funding
This research received no external funding. I acknowledge the funding received from Sweden’s Innovation Agency (Vinnova-2020–2021), the Swedish Strategy Group for EU coordination, and the Sahlgrenska Academy grant (2022–2023) and the funding received from Institute for Advanced Studies in Basic Sciences, Zanjan, Iran (2022–2023).
Acknowledgments
I extend my gratitude to the Editorial Assistants and publishing staff of Biosensors for their support. I am sincerely thankful to all the authors for their invaluable contributions to this Special Issue from various research centers.
Conflicts of Interest
The author declares no conflicts of interest.
List of Contributions
- Abbasi-Moayed, S.; Orouji, A.; Hormozi-Nezhad, M.R. Multiplex Detection of Biogenic Amines for Meat Freshness Monitoring Using Nanoplasmonic Colorimetric Sensor Array. Biosensors 2023, 13, 803. https://doi.org/10.3390/bios13080803.
- Liu, L.; Liu, C.; Gao, L. Highly Sensitive Detection of Chymotrypsin Based on Metal Organic Frameworks with Peptides Sensors. Biosensors 2023, 13, 263. https://doi.org/10.3390/bios13020263.
- Dogan, Ü.; Sucularlı, F.; Yildirim, E.; Cetin, D.; Suludere, Z.; Boyaci, I.H.; Tamer, U. Escherichia coli Enumeration in a Capillary-Driven Microfluidic Chip with SERS. Biosensors 2022, 12, 765. https://doi.org/10.3390/bios12090765.
- Camargo, J.R.; Fernandes-Junior, W.S.; Azzi, D.C.; Rocha, R.G.; Faria, L.V.; Richter, E.M.; Muñoz, R.A.A.; Janegitz, B.C. Development of New Simple Compositions of Silver Inks for the Preparation of Pseudo-Reference Electrodes. Biosensors 2022, 12, 761. https://doi.org/10.3390/bios12090761.
- Gao, L.; Deng, Y.; Liu, H.; Solomon, K.; Zhang, B.; Cai, H. Detection of Pb2+ in Tea Using Aptamer Labeled with AIEgen Nanospheres Based on MOFs Sensors. Biosensors 2022, 12, 745. https://doi.org/10.3390/bios12090745.
- Saeidi, M.; Amidian, M.A.; Sheybanikashani, S.; Mahdavi, H.; Alimohammadi, H.; Syedmoradi, L.; Mohandes, F.; Zarrabi, A.; Tamjid, E.; Omidfar, K.; et al. Multilayered Mesoporous Composite Nanostructures for Highly Sensitive Label-Free Quantification of Cardiac Troponin-I. Biosensors 2022, 12, 337. https://doi.org/10.3390/bios12050337.
- Karimian, T.; Hager, R.; Karner, A.; Weghuber, J.; Lanzerstorfer, P. A Simplified and Robust Activation Procedure of Glass Surfaces for Printing Proteins and Subcellular Micropatterning Experiments. Biosensors 2022, 12, 140. https://doi.org/10.3390/bios12030140.
- Matatagui, D.; Bastida, Á.; Horrillo, M.C. Novel SH-SAW Biosensors for Ultra-Fast Recognition of Growth Factors. Biosensors 2022, 12, 17. https://doi.org/10.3390/bios12010017.
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content. |
© 2024 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).