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Computation, Volume 10, Issue 4

April 2022 - 19 articles

Cover Story: Computer simulations were performed for ivermectin and related compounds on three proteins of interest: (1) the spike glycoprotein of the SARS CoV-2 virus, (2) the CD147 receptor identified as a secondary attachment point for the virus, and (3) the alpha-7 nicotinic acetylcholine receptor, a potential point of viral penetration of neuronal tissue and an activation site for the cholinergic anti-inflammatory pathway. All three of these proteins are predicted to bind ivermectin with significant affinity. Our results suggest a mode of action of ivermectin, which may limit the infectivity of the SARS-CoV-2 virus and stimulate an α7nAChr-mediated anti-inflammatory pathway that could limit cytokine production by immune cells. View this paper
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Articles (19)

  • Article
  • Open Access
14 Citations
6,242 Views
17 Pages

In this paper, we introduce a penalized version of the geometric mean. In analogy with the Mazziotta Pareto Index, this composite indicator is derived as a product between the geometric mean and a penalization term to account for the unbalance among...

  • Article
  • Open Access
10 Citations
3,970 Views
12 Pages

Classifying the Degree of Bark Beetle-Induced Damage on Fir (Abies mariesii) Forests, from UAV-Acquired RGB Images

  • Tobias Leidemer,
  • Orou Berme Herve Gonroudobou,
  • Ha Trang Nguyen,
  • Chiara Ferracini,
  • Benjamin Burkhard,
  • Yago Diez and
  • Maximo Larry Lopez Caceres

Bark beetle outbreaks are responsible for the loss of large areas of forests and in recent years they appear to be increasing in frequency and magnitude as a result of climate change. The aim of this study is to develop a new standardized methodology...

  • Article
  • Open Access
11 Citations
3,756 Views
31 Pages

Modeling the Territorial Structure Dynamics of the Northern Part of the Volga-Akhtuba Floodplain

  • Inessa I. Isaeva,
  • Alexander A. Voronin,
  • Alexander V. Khoperskov and
  • Mikhail A. Kharitonov

The subject of our study is the tendency to reduce the floodplain area of regulated rivers and its impact on the degradation of the socio-environmental systems in the floodplain. The aim of the work is to create a new approach to the analysis and for...

  • Article
  • Open Access
8 Citations
5,073 Views
28 Pages

Co-Design of the Control and Power Stages of a Boost-Based Rectifier with Power Factor Correction Depending on Performance Criteria

  • Carlos Andres Ramos-Paja,
  • Andres Julian Saavedra-Montes and
  • Juan David Bastidas-Rodriguez

Rectifiers with power factor correction are key devices to supply DC loads from AC sources, guaranteeing a power factor close to one and low total harmonic distortion. Boost-based power factor correction rectifiers are the most widely used topology a...

  • Article
  • Open Access
13 Citations
3,446 Views
21 Pages

The aim of this study is to investigate the effects of temperature-dependent viscosity on the natural convection flow from a vertical permeable circular cone with uniform heat flux. As part of numerical computation, the governing boundary layer equat...

  • Article
  • Open Access
6 Citations
5,688 Views
17 Pages

An Alternative Methodology to Compute the Geometric Tortuosity in 2D Porous Media Using the A-Star Pathfinding Algorithm

  • Mayken Espinoza-Andaluz,
  • Javier Pagalo,
  • Joseph Ávila and
  • Julio Barzola-Monteses

Geometric tortuosity is an essential characteristic to consider when studying a porous medium’s morphology. Knowing the material’s tortuosity allows us to understand and estimate the different diffusion transport properties of the analyze...

  • Article
  • Open Access
2 Citations
3,285 Views
9 Pages

Despite the importance of seatbelt use in the reduction of injuries and fatalities, the majority of past studies failed to account for the complex nature of seatbelts on the safety of roadways. The complexity of seatbelt use is especially related to...

  • Article
  • Open Access
2 Citations
3,411 Views
12 Pages

Applying Machine Learning Methods and Models to Explore the Structure of Traffic Accident Data

  • Anton Sysoev,
  • Vladimir Klyavin,
  • Alexandra Dvurechenskaya,
  • Albert Mamedov and
  • Vladislav Shushunov

The problem of reducing the increasing number of road traffic accidents has become more relevant in recent years. According to the United Nations plan this number has to be halved by 2030. A very effective way to handle it is to apply the machine lea...

  • Article
  • Open Access
3 Citations
3,301 Views
24 Pages

Water is a basic necessity and one of the most valuable resources for human living. Sadly, large quantities of treated water get lost daily worldwide, especially in developing countries, through leaks in the water distribution network. Wireless senso...

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Computation - ISSN 2079-3197