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Open AccessArticle

Effects of Marine Toxin Domoic Acid on Innate Immune Responses in Bay Scallop Argopecten irradians

Key Laboratory of Aquatic Nutrition and Feed Science of Jiangsu Province, College of Animal Science and Technology, Nanjing Agricultural University, No. 1 Weigang Road, Nanjing 210095, Jiangsu Province, China
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These authors contributed equally to this work.
J. Mar. Sci. Eng. 2019, 7(11), 407; https://doi.org/10.3390/jmse7110407
Received: 12 October 2019 / Revised: 18 October 2019 / Accepted: 21 October 2019 / Published: 9 November 2019
Domoic acid (DA) is an amnesic shellfish poisoning toxin produced by some species of the genera Pseudo-nitzschia and Nitzschia. This toxin has harmful effects on various species, especially scallops. This study aimed to investigate the effects of DA exposure on the immune and physical responses of bay scallop, Argopecten irradians. Various immunological and physical parameters were assessed (acid phosphatase (ACP), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), lipid peroxide (LPO), nitric oxide (NO), and the total protein content) in the haemolymph of scallops at 3, 6, 12, 24, and 48 h post-exposure to DA at different concentrations (10, 50, and 100 ng/mL). Moreover, the expression of immune-related genes (CLT-6, FREP, HSP90, MT, PGRP, and PrxV) was assessed. The activities of ACP, ALP, and LDH and the total protein content and LPO increased upon exposure to DA at different concentrations, while NO levels were decreased. Furthermore, immune-related genes were assessed upon DA exposure. Our results showed that exposure to DA negatively impacts immune function and disrupts physiological activities in bay scallops. View Full-Text
Keywords: Domoic acid; bay scallop; Argopecten irradians; harmful algal blooms; immune response Domoic acid; bay scallop; Argopecten irradians; harmful algal blooms; immune response
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MDPI and ACS Style

Chi, C.; Zhang, C.; Liu, J.; Zheng, X. Effects of Marine Toxin Domoic Acid on Innate Immune Responses in Bay Scallop Argopecten irradians. J. Mar. Sci. Eng. 2019, 7, 407.

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