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Transcatheter Mitral Repair for Functional Mitral Regurgitation According to Left Ventricular Function: A Real-Life Propensity-Score Matched Study

Heart Area, Asturias Central University Hospital, University of Oviedo, Instituto Investigación Sanitaria Principado de Asturias (ISPA), 33011 Oviedo, Spain
Cardiology Department, Virgen de la Victoria University Hospital, Instituto de Investigación Biomédica de Málaga (IBIMA), University of Málaga, CIBERCV, 29010 Málaga, Spain
Cardiology Department. University Hospital of León, 24008 León, Spain
Cardiology Department, Santa Creu i Sant Pau Hospital, 08041 Barcelona, Spain
Cardiovascular Institute, Hospital Clínico San Carlos, IdISSC, 28040 Madrid, Spain
Cardiology Department, Reina Sofía University Hospital, University of Córdoba (IMIBIC), 14004 Córdoba, Spain
CIBERCV, Cardiology Department, Hospital Clínico Universitario de Valladolid, 47003 Valladolid, Spain
Cardiology Department, Institut Clínic Cardiovascular, Hospital Clinic de Barcelona, 08036 Barcelona, Spain
Cardiology Department, Complejo Hospitalario Universitario de Santiago de Compostela, CIBERCV, 15706 Santiago de Compostela, Spain
Cardiology Department, Ramon y Cajal University Hospital, 28034 Madrid, Spain
Cardiology Department, Hospital Universitario de Basurto, 48013 Bilbao, Spain
Cardiology Department, University Hospital of Salamanca, IBSAL, Institute of Biomedical Research of Salamanca, University of Salamanca, CIBERCV, 37007 Salamanca, Spain
Cardiology Department, University Hospital of Badajoz, 06080 Badajoz, Spain
Cardiology Department, Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain
Cardiology Department, Hospital General Universitario de Valencia, 46014 Valencia, Spain
Cardiology Department, University Clinic Hospital of Valencia, University of Valencia, INCLIVA, CIBERCV, 46010 Valencia, Spain
Cardiology Department, Complejo Hospitalario de Navarra, 31008 Pamplona, Spain
Cardiology Department., Complejo Hospital Regional Universitario de Málaga, 29010 Málaga, Spain
Cardiology Department, University Hospital Puerta de Hierro/Majadahonda, 28222 Madrid, Spain
Cardiology Department, University Hospital Miguel Servet, 50009 Zaragoza, Spain
Cardiology Department, University Hospital Virgen de las Nieves, 18014 Granada, Spain
Cardiology Department, Hospital Universitari Germans Trias i Pujol, 08916 Barcelona, Spain
Cardiology Department, Alvaro Cunqueiro University Hospital, 36213 Vigo, Spain
Author to whom correspondence should be addressed.
J. Clin. Med. 2020, 9(6), 1792;
Received: 28 April 2020 / Revised: 24 May 2020 / Accepted: 1 June 2020 / Published: 9 June 2020
(This article belongs to the Special Issue New Frontiers in Cardiovascular Intervention)
Background: Transcatheter mitral valve repair (TMVR) could improve survival in functional mitral regurgitation (FMR), but it is necessary to consider the influence of left ventricular ejection fraction (LVEF). Therefore, we compare the outcomes after TMVR with Mitraclip® between two groups according to LVEF. Methods: In an observational registry study, we compared the outcomes in patients with FMR who underwent TMVR with and without LVEF <30%. The primary endpoint was the combined one-year all-cause mortality and unplanned hospital readmissions due to HF. The secondary end-points were New York Heart Association (NYHA) functional class and mitral regurgitation (MR) severity. Propensity-score matching was used to create two groups with the same baseline characteristics, except for baseline LVEF. Results: Among 535 FMR eligible patients, 144 patients with LVEF <30% (group 1) and 144 with LVEF >30% (group 2) had similar propensity scores and were included in the analyses. The primary study endpoint was significantlly higher in group 1 (33.3% vs. 9.4%, p = 0.002). There was a maintained improvement in secondary endpoints without significant differences among groups. Conclusion: FMR patients with LVEF <30% treated with MitraClip® had higher mortality and readmissions than patients with LVEF ≥30% treated with the same device. However, both groups improved the NYHA functional class and MR severity. View Full-Text
Keywords: Mitraclip; functional mitral regurgitation; transcatheter; left ventricular ejection Fraction Mitraclip; functional mitral regurgitation; transcatheter; left ventricular ejection Fraction
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MDPI and ACS Style

Pascual, I.; Carrasco-Chinchilla, F.; Benito-Gonzalez, T.; Li, C.H.; Avanzas, P.; Nombela-Franco, L.; Pan, M.; Serrador Frutos, A.; Freixa, X.; Trillo-Nouche, R.; Hernández-Antolín, R.A.; Andraka Ikazuriaga, L.; Cruz-Gonzalez, I.; López-Mínguez, J.R.; Diez, J.L.; Berenguer-Jofresa, A.; Sanchis, J.; Ruiz-Quevedo, V.; Urbano-Carrillo, C.; Dominguez, J.F.O.; Ortas-Nadal, M.R.; Molina Navarro, E.; Carrillo, X.; Alonso-Briales, J.H.; Fernández-Vázquez, F.; Asmarats Serra, L.; Hernandez-Vaquero, D.; Jimenez-Quevedo, P.; Mesa, D.; Rodríguez-Gabella, T.; Regueiro, A.; Martinez Monzonís, A.; Salido Tahoces, L.; Ruiz Gomez, L.; Trejo-Velasco, B.; Becerra-Muñoz, V.M.; Garrote-Coloma, C.; Fernández Peregrina, E.; Lorca, R.; Agustín, J.A.D.; Romero, M.; Amat-Santos, I.J.; Sabaté, M.; Alvarez, A.B.C.; Hernandez-Garcia, J.M.; Gualis, J.; Arzamendi, D.; Moris, C.; Tirado-Conte, G.; Sánchez-Recalde, A.; Estevez-Loureiro, R. Transcatheter Mitral Repair for Functional Mitral Regurgitation According to Left Ventricular Function: A Real-Life Propensity-Score Matched Study. J. Clin. Med. 2020, 9, 1792.

AMA Style

Pascual I, Carrasco-Chinchilla F, Benito-Gonzalez T, Li CH, Avanzas P, Nombela-Franco L, Pan M, Serrador Frutos A, Freixa X, Trillo-Nouche R, Hernández-Antolín RA, Andraka Ikazuriaga L, Cruz-Gonzalez I, López-Mínguez JR, Diez JL, Berenguer-Jofresa A, Sanchis J, Ruiz-Quevedo V, Urbano-Carrillo C, Dominguez JFO, Ortas-Nadal MR, Molina Navarro E, Carrillo X, Alonso-Briales JH, Fernández-Vázquez F, Asmarats Serra L, Hernandez-Vaquero D, Jimenez-Quevedo P, Mesa D, Rodríguez-Gabella T, Regueiro A, Martinez Monzonís A, Salido Tahoces L, Ruiz Gomez L, Trejo-Velasco B, Becerra-Muñoz VM, Garrote-Coloma C, Fernández Peregrina E, Lorca R, Agustín JAD, Romero M, Amat-Santos IJ, Sabaté M, Alvarez ABC, Hernandez-Garcia JM, Gualis J, Arzamendi D, Moris C, Tirado-Conte G, Sánchez-Recalde A, Estevez-Loureiro R. Transcatheter Mitral Repair for Functional Mitral Regurgitation According to Left Ventricular Function: A Real-Life Propensity-Score Matched Study. Journal of Clinical Medicine. 2020; 9(6):1792.

Chicago/Turabian Style

Pascual, Isaac, Fernando Carrasco-Chinchilla, Tomas Benito-Gonzalez, Chi H. Li, Pablo Avanzas, Luis Nombela-Franco, Manuel Pan, Ana Serrador Frutos, Xavier Freixa, Ramiro Trillo-Nouche, Rosa A. Hernández-Antolín, Leire Andraka Ikazuriaga, Ignacio Cruz-Gonzalez, Jose R. López-Mínguez, Jose L. Diez, Alberto Berenguer-Jofresa, Juan Sanchis, Valeriano Ruiz-Quevedo, Cristobal Urbano-Carrillo, Juan F.O. Dominguez, Maria R. Ortas-Nadal, Eduardo Molina Navarro, Xavier Carrillo, Juan H. Alonso-Briales, Felipe Fernández-Vázquez, Luis Asmarats Serra, Daniel Hernandez-Vaquero, Pilar Jimenez-Quevedo, Dolores Mesa, Tania Rodríguez-Gabella, Ander Regueiro, Amparo Martinez Monzonís, Luisa Salido Tahoces, Lara Ruiz Gomez, Blanca Trejo-Velasco, Victor M. Becerra-Muñoz, Carmen Garrote-Coloma, Estafanía Fernández Peregrina, Rebeca Lorca, Jose A.D. Agustín, Miguel Romero, Ignacio J. Amat-Santos, Manel Sabaté, Ana B.C. Alvarez, Jose M. Hernandez-Garcia, Javier Gualis, Dabit Arzamendi, Cesar Moris, Gabriela Tirado-Conte, Angel Sánchez-Recalde, and Rodrigo Estevez-Loureiro. 2020. "Transcatheter Mitral Repair for Functional Mitral Regurgitation According to Left Ventricular Function: A Real-Life Propensity-Score Matched Study" Journal of Clinical Medicine 9, no. 6: 1792.

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