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In Vitro and In Vivo Effects of Gracilaria verrucosa Extracts on Osteoclast Differentiation

Department of Pharmacy, Sunchon National University, Jeonnam, Suncheon 57922, Korea
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Author to whom correspondence should be addressed.
Academic Editor: Hirohiko Okamura
J. Clin. Med. 2017, 6(3), 32; https://doi.org/10.3390/jcm6030032
Received: 30 December 2016 / Revised: 6 March 2017 / Accepted: 10 March 2017 / Published: 14 March 2017
(This article belongs to the Special Issue Bone Cell Biology and Transcriptional Regulation)
Bone remodeling, a physiological process characterized by bone formation by osteoblasts and bone resorption by osteoclasts, is important for the maintenance of healthy bone in adult humans. Osteoclasts play a critical role in bone erosion and osteoporosis and are bone-specific multinucleated cells generated through differentiation of monocyte/macrophage lineage precursors. Receptor activator of NF-κB ligand (RANKL) has been reported to induce osteoclast differentiation. In this study, we explored whether Gracilaria verrucosa extracts (GE) could affect RANKL-mediated osteoclast differentiation. GE significantly inhibited RANKL-activated osteoclast differentiation by inhibiting protein expression of c-fos and nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), vital factors in RANKL-mediated osteoclastogenesis. In addition, GE attenuated ovariectomy-induced bone loss in mice. In summary, GE can prevent osteoclastogenesis and hormone-related bone loss via blockage of c-fos-NFATc1 signaling. Our results suggest that GE may have therapeutic potential in the treatment of postmenopausal osteoporosis. View Full-Text
Keywords: bone; osteoporosis; osteoclast; receptor activator of nuclear factor-κB ligand (RANKL); nuclear factor of activated T-cells; cytoplasmic 1 (NFATc1); in vivo; seaweed; Gracilaria verrucosa bone; osteoporosis; osteoclast; receptor activator of nuclear factor-κB ligand (RANKL); nuclear factor of activated T-cells; cytoplasmic 1 (NFATc1); in vivo; seaweed; Gracilaria verrucosa
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Kim, K.-J.; Lee, Y.-J.; Hwang, Y.-H.; Kang, K.-Y.; Yee, S.-T.; Son, Y.-J. In Vitro and In Vivo Effects of Gracilaria verrucosa Extracts on Osteoclast Differentiation. J. Clin. Med. 2017, 6, 32.

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