Next Article in Journal
Copper Sources for Sod1 Activation
Previous Article in Journal
The Role of Nutri(epi)genomics in Achieving the Body’s Full Potential in Physical Activity
Previous Article in Special Issue
Oxidative Stress and BPA Toxicity: An Antioxidant Approach for Male and Female Reproductive Dysfunction
Open AccessArticle

Composition of Royal Jelly (RJ) and Its Anti-Androgenic Effect on Reproductive Parameters in a Polycystic Ovarian Syndrome (PCOS) Animal Model

1
Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Malaysia
2
Department of Pathology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Malaysia
3
Unit of Women’s Health Development, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Malaysia
4
Unit of Physiology, Faculty of Medicine, Universiti Sultan Zainal Abidin, Kuala Terengganu 20400, Malaysia
5
Unit of Integrative Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian 16150, Malaysia
*
Author to whom correspondence should be addressed.
Antioxidants 2020, 9(6), 499; https://doi.org/10.3390/antiox9060499
Received: 1 May 2020 / Revised: 30 May 2020 / Accepted: 5 June 2020 / Published: 7 June 2020
(This article belongs to the Special Issue Effect of Oxidative Stress on Reproduction and Development)
Royal jelly (RJ) has been shown to contribute its positive effects upon imbalance in the reproductive system. However, it remains unknown as to whether RJ has an anti-androgenic effect on reproductive parameters in a polycystic ovarian syndrome (PCOS) animal model. Composition of RJ was assessed by phytochemical screening and the LC–MS method. Forty immature female rats (3 weeks, 40–50 g) were randomly divided into five groups (n = 8 per group), i.e., control, testosterone (T), T+100RJ (100 mg/kg/day), T+200RJ (200 mg/kg/day RJ), and T+400RJ (400 mg/kg/day RJ) groups. Hyperandrogenism was induced by daily subcutaneous injection of T propionate for 3 weeks, followed by oral RJ for 4 weeks. The T+200RJ group had a significantly higher follicle-stimulating hormone level, and significantly lower luteinizing hormone, testosterone, and estradiol levels in comparison to the T group. Malondialdehyde level and glutathione peroxidase activity were significantly lower, while total antioxidant capacity level was significantly higher in the T+200RJ group compared to the T group. Histologically, the T+200RJ group showed recovery of various stages of ovarian follicular development. RJ at 200 mg/kg/day for 4 weeks significantly improved reproductive parameters in PCOS rats partly due to its anti-androgenic effect through antioxidant action and probably due to modulation on estrogenic activity, which needs further study to evaluate its exact mechanism of action. View Full-Text
Keywords: polycystic ovary syndrome; royal jelly; immature rats; antioxidant; LC–MS polycystic ovary syndrome; royal jelly; immature rats; antioxidant; LC–MS
Show Figures

Figure 1

MDPI and ACS Style

Ab Hamid, N.; Abu Bakar, A.B.; Mat Zain, A.A.; Nik Hussain, N.H.; Othman, Z.A.; Zakaria, Z.; Mohamed, M. Composition of Royal Jelly (RJ) and Its Anti-Androgenic Effect on Reproductive Parameters in a Polycystic Ovarian Syndrome (PCOS) Animal Model. Antioxidants 2020, 9, 499.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop