Special Issue "Non-motor and Non-dopaminergic Symptoms in Parkinson’s Disease"
Deadline for manuscript submissions: 10 April 2022.
2. Université Claude Bernard Lyon 1, 69100 Villeurbanne, France
3. INSERM, U 1028, Lyon Neuroscience Research Center, 69000 Lyon, France
4. CNRS, UMR 5292, Lyon Neuroscience Research Center, 69000 Lyon, France
Interests: Parkinson’s disease; neuroimaging; PET; neurotransmission; noradrenaline; dopamine; serotonin; executive control; inhibitory control; motor control; non-motor symptoms
Parkinson’s disease has traditionally been considered as a neurological pathology characterized by a progressive, irreversible and ultimately disabling motor deficit related to low dopamine levels within the striatum secondary to the degeneration of dopaminergic neurons of the substantia nigra pars compacta. Up until now, focus on the nigrostriatal dopaminergic system has been justified by the prominent motor manifestations for which patients seek treatment and by the remarkable success of dopaminergic replacement therapy. However, while those treatments have improved the prognosis of motor symptoms, they are, at the same time, a new source of disability because of their undesired effects (e.g., dyskinesia and pathological gambling). In addition, most of the current disability brought on by parkinsonian patients relates to symptoms that respond poorly to levodopa (axial motor symptoms) and/or to non-motor features of Parkinson’s disease, such as cognitive or psychiatric disturbance. Recognition of non-motor symptoms is essential, not only for ascertaining the functional status of patients but also for better appreciating the nature of the neurodegenerative process in Parkinson’s disease. Accordingly, this Special Issue is devoted to bringing new insights from animal and human studies into the respective roles of monoamines, such as acetylcholine, noradrenaline or serotonin in the pathophysiology of non-motor symptoms in Parkinson’s disease.
Dr. Bénédicte Ballanger
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- non-motor symptoms