Hot and Cold Cognitive Disturbances in Parkinson Patients Treated with DBS-STN: A Combined PET and Neuropsychological Study
Abstract
:1. Introduction
2. Materials and Methods
2.1. Subjects
2.2. Study Design
2.3. Primary Outcomes
2.3.1. Cognitive Measures
2.3.2. Mood State Measures
2.3.3. Brain Imaging with PET [11C]AZ10419369
2.4. Statistical Analyses
3. Results
3.1. Baseline Data
3.1.1. Cold and Hot Cognition
3.1.2. Mood States
3.2. Correlations between Cognition and [11C]AZ10419369 PET
3.2.1. Cold Cognition Correlates with BPND0
3.2.2. Hot Cognition Correlates with BPND0
3.3. Turning DBS-STN Off
3.3.1. Effects on Mood States
3.3.2. Worsening in Mood State Correlates with [11C]AZ10419369 PET
4. Discussion
4.1. Baseline Cognition
4.2. Association to [11C]AZ10419369 PET
4.3. Turning DBS-STN Off
4.4. Limitations
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Healthy Controls | Parkinson’s Disease | |||||||
---|---|---|---|---|---|---|---|---|
Mean | SD | Range | n | Mean | SD | Range | n | |
Cold Cognition | ||||||||
Working memory (LNS) | 11.3 | 1.9 | [8–14] | 11 | 8.3 * | 2.6 | [3–12] | 12 |
Hot Cognition | ||||||||
Verbal affective memory (VAMT-26 bias) | 0.2 | 1.1 | [−1.9–2.5] | 11 | −0.5 | 1.2 | [−2.6–1.1] | 12 |
Face recognition (ER bias) | 23.4 | 16.4 | [0–45] | 5 | 24.1 | 16.9 | [−8–52] | 12 |
Mood state | ||||||||
Profile of Mood State (POMS-TMD) | −6.5 | 14.6 | [−19–21] | 11 | −6.5 | 15.0 | [−20–24] | 12 |
[11C]AZ10419369 PET (a) | ||||||||
Temporal cortex (BPND0) | 0.95 | 0.25 | [0.58–1.48] | 10 | 0.79 | 0.15 | [0.72–1.39] | 13 |
Limbic cortex (BPND0) | 1.28 | 0.32 | [0.72–2.00] | 10 | 1.02 | 0.21 | [0.57–1.11] | 13 |
Temporal cortex (ΔBPND (%)) | 3 | 11 | [−19–20] | 10 | −11 | 9 | [−29–1] | 13 |
Limbic cortex (ΔBPND (%)) | 2 | 7 | [−17–12] | 10 | −9 | 12 | [−27–9] | 13 |
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Jørgensen, L.M.; Henriksen, T.; Mardosiene, S.; Wyon, O.; Keller, S.H.; Jespersen, B.; Knudsen, G.M.; Stenbæk, D.S. Hot and Cold Cognitive Disturbances in Parkinson Patients Treated with DBS-STN: A Combined PET and Neuropsychological Study. Brain Sci. 2022, 12, 654. https://doi.org/10.3390/brainsci12050654
Jørgensen LM, Henriksen T, Mardosiene S, Wyon O, Keller SH, Jespersen B, Knudsen GM, Stenbæk DS. Hot and Cold Cognitive Disturbances in Parkinson Patients Treated with DBS-STN: A Combined PET and Neuropsychological Study. Brain Sciences. 2022; 12(5):654. https://doi.org/10.3390/brainsci12050654
Chicago/Turabian StyleJørgensen, Louise M., Tove Henriksen, Skirmante Mardosiene, Ottilia Wyon, Sune H. Keller, Bo Jespersen, Gitte M. Knudsen, and Dea S. Stenbæk. 2022. "Hot and Cold Cognitive Disturbances in Parkinson Patients Treated with DBS-STN: A Combined PET and Neuropsychological Study" Brain Sciences 12, no. 5: 654. https://doi.org/10.3390/brainsci12050654